The Effect of Eighteen-Month Metformin Treatment in Obese Adolescents: Comparison of Results Obtained in Daily Practice with Results from a Clinical Trial
Background. In a recent randomized controlled trial (RCT) in obese adolescents, 18 month-treatment with metformin versus placebo was reported to lead to stabilisation of the BMI. This study aimed to compare the effect of metformin on BMI in obese adolescents in daily practice versus results obtained...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2016/7852648 |
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| author | Marloes P. van der Aa Vera Hoving Ewoudt M. W. van de Garde Antonius de Boer Catherijne A. J. Knibbe Marja M. J. van der Vorst |
| author_facet | Marloes P. van der Aa Vera Hoving Ewoudt M. W. van de Garde Antonius de Boer Catherijne A. J. Knibbe Marja M. J. van der Vorst |
| author_sort | Marloes P. van der Aa |
| collection | DOAJ |
| description | Background. In a recent randomized controlled trial (RCT) in obese adolescents, 18 month-treatment with metformin versus placebo was reported to lead to stabilisation of the BMI. This study aimed to compare the effect of metformin on BMI in obese adolescents in daily practice versus results obtained in an RCT. Methods. Obese adolescents treated off label with metformin in daily practice in an outpatient clinic with a follow-up of ≥18 months were identified. Anthropometric and biochemical data were collected at baseline and at 18 months. Patients treated with metformin for 18 months in an RCT were used for comparison. BMI was compared between the two groups. Results. Nineteen patients (median age 14.3 (interquartile range 11.7–15.7) years, BMI 31.3 (28.8–33.8) kg/m2) treated in daily practice were compared to 23 patients receiving metformin in the RCT (age 13.6 (12.6–15.3) years, BMI 29.8 (28.1–34.5) kg/m2). BMI change after 18 months was −0.36 (−2.10–1.58) versus +0.22 (−2.87–1.27) kg/m2 for the two groups, respectively. In the multivariable model, BMI change was not statistically significantly different between the two groups (p=0.61). Conclusion. Treatment with metformin in obese adolescents in daily practice resulted in a comparable change in BMI as observed in an RCT. This trial is registered with ClinicalTrials.gov number: NCT01487993. |
| format | Article |
| id | doaj-art-318d144ef3284d048fdd787103d0a0bc |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-318d144ef3284d048fdd787103d0a0bc2025-02-03T01:07:54ZengWileyJournal of Obesity2090-07082090-07162016-01-01201610.1155/2016/78526487852648The Effect of Eighteen-Month Metformin Treatment in Obese Adolescents: Comparison of Results Obtained in Daily Practice with Results from a Clinical TrialMarloes P. van der Aa0Vera Hoving1Ewoudt M. W. van de Garde2Antonius de Boer3Catherijne A. J. Knibbe4Marja M. J. van der Vorst5Department of Pediatrics, St. Antonius Hospital, Nieuwegein/Utrecht, P.O. Box 2500, 3430 EM Nieuwegein, NetherlandsDepartment of Pediatrics, St. Antonius Hospital, Nieuwegein/Utrecht, P.O. Box 2500, 3430 EM Nieuwegein, NetherlandsDepartment of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein/Utrecht, P.O. Box 2500, 3430 EM Nieuwegein, NetherlandsDivision of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, P.O. Box 80082, 3508 TB Utrecht, NetherlandsDepartment of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein/Utrecht, P.O. Box 2500, 3430 EM Nieuwegein, NetherlandsDepartment of Pediatrics, St. Antonius Hospital, Nieuwegein/Utrecht, P.O. Box 2500, 3430 EM Nieuwegein, NetherlandsBackground. In a recent randomized controlled trial (RCT) in obese adolescents, 18 month-treatment with metformin versus placebo was reported to lead to stabilisation of the BMI. This study aimed to compare the effect of metformin on BMI in obese adolescents in daily practice versus results obtained in an RCT. Methods. Obese adolescents treated off label with metformin in daily practice in an outpatient clinic with a follow-up of ≥18 months were identified. Anthropometric and biochemical data were collected at baseline and at 18 months. Patients treated with metformin for 18 months in an RCT were used for comparison. BMI was compared between the two groups. Results. Nineteen patients (median age 14.3 (interquartile range 11.7–15.7) years, BMI 31.3 (28.8–33.8) kg/m2) treated in daily practice were compared to 23 patients receiving metformin in the RCT (age 13.6 (12.6–15.3) years, BMI 29.8 (28.1–34.5) kg/m2). BMI change after 18 months was −0.36 (−2.10–1.58) versus +0.22 (−2.87–1.27) kg/m2 for the two groups, respectively. In the multivariable model, BMI change was not statistically significantly different between the two groups (p=0.61). Conclusion. Treatment with metformin in obese adolescents in daily practice resulted in a comparable change in BMI as observed in an RCT. This trial is registered with ClinicalTrials.gov number: NCT01487993.http://dx.doi.org/10.1155/2016/7852648 |
| spellingShingle | Marloes P. van der Aa Vera Hoving Ewoudt M. W. van de Garde Antonius de Boer Catherijne A. J. Knibbe Marja M. J. van der Vorst The Effect of Eighteen-Month Metformin Treatment in Obese Adolescents: Comparison of Results Obtained in Daily Practice with Results from a Clinical Trial Journal of Obesity |
| title | The Effect of Eighteen-Month Metformin Treatment in Obese Adolescents: Comparison of Results Obtained in Daily Practice with Results from a Clinical Trial |
| title_full | The Effect of Eighteen-Month Metformin Treatment in Obese Adolescents: Comparison of Results Obtained in Daily Practice with Results from a Clinical Trial |
| title_fullStr | The Effect of Eighteen-Month Metformin Treatment in Obese Adolescents: Comparison of Results Obtained in Daily Practice with Results from a Clinical Trial |
| title_full_unstemmed | The Effect of Eighteen-Month Metformin Treatment in Obese Adolescents: Comparison of Results Obtained in Daily Practice with Results from a Clinical Trial |
| title_short | The Effect of Eighteen-Month Metformin Treatment in Obese Adolescents: Comparison of Results Obtained in Daily Practice with Results from a Clinical Trial |
| title_sort | effect of eighteen month metformin treatment in obese adolescents comparison of results obtained in daily practice with results from a clinical trial |
| url | http://dx.doi.org/10.1155/2016/7852648 |
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