Pan-Cancer Analysis of B4GALNT1 as a Potential Prognostic and Immunological Biomarker
Background. Gangliosides act as important roles in tumor progression. B4GALNT1 is a key enzyme in ganglioside biosynthesis. B4GALNT1 expression is linked to tumorigenesis and the prognosis of tumor patients. Nevertheless, the role of B4GALNT1 in pan-cancer remains unclear. Methods. Several databases...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/4355890 |
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| author | Hang Yi Yiwen Lin Yutong Li Yeqi Guo Ligong Yuan Yousheng Mao |
| author_facet | Hang Yi Yiwen Lin Yutong Li Yeqi Guo Ligong Yuan Yousheng Mao |
| author_sort | Hang Yi |
| collection | DOAJ |
| description | Background. Gangliosides act as important roles in tumor progression. B4GALNT1 is a key enzyme in ganglioside biosynthesis. B4GALNT1 expression is linked to tumorigenesis and the prognosis of tumor patients. Nevertheless, the role of B4GALNT1 in pan-cancer remains unclear. Methods. Several databases, including TCGA, GEO, GTEx, NCI-60, and TIMER, were searched. Methods including correlation analysis, Cox regression analysis, and Kaplan-Meier analysis were used to explore the expression pattern, prognosis, tumor infiltration pattern, genetics and epigenetics, and drug sensitivity of B4GALNT1 in pan-cancer patients from the above datasets. Results. B4GALNT1 was found to be aberrantly expressed in multiple types of tumors. The survival status of tumor patients was significantly related to B4GALNT1 expression, but the correlations were tumor-specific. Moreover, the expression of B4GALNT1 was associated with ImmuneScore and StromalScore in 21 and 27 tumor types, respectively. Also, B4GALNT1 was significantly associated with TMB, MSI, MMR, and DNA methylation. Additionally, the sensitivity of 9 drugs was correlated with the expression of B4GALNT1. Conclusion. A correlation of B4GALNT1 expression with prognosis exists in multiple types of cancers. In addition, B4GALNT1 expression may play a role in TME and tumor immunity regulation. Further investigation of the biological mechanisms of its different roles in tumorigenesis and clinical application as a biomarker is still required. |
| format | Article |
| id | doaj-art-3180ab48411349cab5ff47dcac694f93 |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-3180ab48411349cab5ff47dcac694f932025-02-03T05:49:24ZengWileyJournal of Immunology Research2314-71562022-01-01202210.1155/2022/4355890Pan-Cancer Analysis of B4GALNT1 as a Potential Prognostic and Immunological BiomarkerHang Yi0Yiwen Lin1Yutong Li2Yeqi Guo3Ligong Yuan4Yousheng Mao5Department of Thoracic SurgeryDepartment of Medical OncologyPeking University Health Science CenterPeking University Health Science CenterDepartment of Thoracic SurgeryDepartment of Thoracic SurgeryBackground. Gangliosides act as important roles in tumor progression. B4GALNT1 is a key enzyme in ganglioside biosynthesis. B4GALNT1 expression is linked to tumorigenesis and the prognosis of tumor patients. Nevertheless, the role of B4GALNT1 in pan-cancer remains unclear. Methods. Several databases, including TCGA, GEO, GTEx, NCI-60, and TIMER, were searched. Methods including correlation analysis, Cox regression analysis, and Kaplan-Meier analysis were used to explore the expression pattern, prognosis, tumor infiltration pattern, genetics and epigenetics, and drug sensitivity of B4GALNT1 in pan-cancer patients from the above datasets. Results. B4GALNT1 was found to be aberrantly expressed in multiple types of tumors. The survival status of tumor patients was significantly related to B4GALNT1 expression, but the correlations were tumor-specific. Moreover, the expression of B4GALNT1 was associated with ImmuneScore and StromalScore in 21 and 27 tumor types, respectively. Also, B4GALNT1 was significantly associated with TMB, MSI, MMR, and DNA methylation. Additionally, the sensitivity of 9 drugs was correlated with the expression of B4GALNT1. Conclusion. A correlation of B4GALNT1 expression with prognosis exists in multiple types of cancers. In addition, B4GALNT1 expression may play a role in TME and tumor immunity regulation. Further investigation of the biological mechanisms of its different roles in tumorigenesis and clinical application as a biomarker is still required.http://dx.doi.org/10.1155/2022/4355890 |
| spellingShingle | Hang Yi Yiwen Lin Yutong Li Yeqi Guo Ligong Yuan Yousheng Mao Pan-Cancer Analysis of B4GALNT1 as a Potential Prognostic and Immunological Biomarker Journal of Immunology Research |
| title | Pan-Cancer Analysis of B4GALNT1 as a Potential Prognostic and Immunological Biomarker |
| title_full | Pan-Cancer Analysis of B4GALNT1 as a Potential Prognostic and Immunological Biomarker |
| title_fullStr | Pan-Cancer Analysis of B4GALNT1 as a Potential Prognostic and Immunological Biomarker |
| title_full_unstemmed | Pan-Cancer Analysis of B4GALNT1 as a Potential Prognostic and Immunological Biomarker |
| title_short | Pan-Cancer Analysis of B4GALNT1 as a Potential Prognostic and Immunological Biomarker |
| title_sort | pan cancer analysis of b4galnt1 as a potential prognostic and immunological biomarker |
| url | http://dx.doi.org/10.1155/2022/4355890 |
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