Variant Guillain-Barré Syndrome in a Patient with Non-Hodgkin’s Lymphoma
We report a 72-year-old female patient with diffuse large B cell non-Hodgkin’s lymphoma (NHL) with previous treatment with standard chemotherapy presenting as an acute, ascending, sensorimotor polyneuropathy. Nerve conduction studies and lumbar puncture supported a rare, but ominous, axonal variant...
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| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2015/979237 |
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| author | R. H. Bishay J. Paton V. Abraham |
| author_facet | R. H. Bishay J. Paton V. Abraham |
| author_sort | R. H. Bishay |
| collection | DOAJ |
| description | We report a 72-year-old female patient with diffuse large B cell non-Hodgkin’s lymphoma (NHL) with previous treatment with standard chemotherapy presenting as an acute, ascending, sensorimotor polyneuropathy. Nerve conduction studies and lumbar puncture supported a rare, but ominous, axonal variant of Guillain-Barré Syndrome (GBS) known as acute motor and sensory axonal neuropathy (AMSAN), which is distinguished from the more common, acute demyelinating forms of GBS. Previous reports have largely focused on toxicities secondary to chemo- or radiotherapy as a major contributor to the development of acute neuropathies in malignancy. Clinicians should also be mindful of direct neoplastic invasion or, less commonly, paraneoplastic phenomenon, as alternative mechanisms, the latter possibly reflecting immune dysregulation in particularly aggressive lymphomas. At the time of writing, this is the first report in the literature of an axonal variant of GBS in a patient with diffuse large B cell NHL. A discussion regarding common and uncommon neuropathies in haematological malignancies is made, with a brief review of the anecdotal evidence supporting a paraneoplastic association with GBS or its variant forms in the setting of lymphoma. |
| format | Article |
| id | doaj-art-317bdf4e44ed459480a414dbe3600f23 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-317bdf4e44ed459480a414dbe3600f232025-02-03T01:10:24ZengWileyCase Reports in Hematology2090-65602090-65792015-01-01201510.1155/2015/979237979237Variant Guillain-Barré Syndrome in a Patient with Non-Hodgkin’s LymphomaR. H. Bishay0J. Paton1V. Abraham2St George Hospital, Kogarah, Sydney, NSW 2217, AustraliaSt George Hospital, Kogarah, Sydney, NSW 2217, AustraliaShoalhaven District Memorial Hospital, Nowra, NSW 2541, AustraliaWe report a 72-year-old female patient with diffuse large B cell non-Hodgkin’s lymphoma (NHL) with previous treatment with standard chemotherapy presenting as an acute, ascending, sensorimotor polyneuropathy. Nerve conduction studies and lumbar puncture supported a rare, but ominous, axonal variant of Guillain-Barré Syndrome (GBS) known as acute motor and sensory axonal neuropathy (AMSAN), which is distinguished from the more common, acute demyelinating forms of GBS. Previous reports have largely focused on toxicities secondary to chemo- or radiotherapy as a major contributor to the development of acute neuropathies in malignancy. Clinicians should also be mindful of direct neoplastic invasion or, less commonly, paraneoplastic phenomenon, as alternative mechanisms, the latter possibly reflecting immune dysregulation in particularly aggressive lymphomas. At the time of writing, this is the first report in the literature of an axonal variant of GBS in a patient with diffuse large B cell NHL. A discussion regarding common and uncommon neuropathies in haematological malignancies is made, with a brief review of the anecdotal evidence supporting a paraneoplastic association with GBS or its variant forms in the setting of lymphoma.http://dx.doi.org/10.1155/2015/979237 |
| spellingShingle | R. H. Bishay J. Paton V. Abraham Variant Guillain-Barré Syndrome in a Patient with Non-Hodgkin’s Lymphoma Case Reports in Hematology |
| title | Variant Guillain-Barré Syndrome in a Patient with Non-Hodgkin’s Lymphoma |
| title_full | Variant Guillain-Barré Syndrome in a Patient with Non-Hodgkin’s Lymphoma |
| title_fullStr | Variant Guillain-Barré Syndrome in a Patient with Non-Hodgkin’s Lymphoma |
| title_full_unstemmed | Variant Guillain-Barré Syndrome in a Patient with Non-Hodgkin’s Lymphoma |
| title_short | Variant Guillain-Barré Syndrome in a Patient with Non-Hodgkin’s Lymphoma |
| title_sort | variant guillain barre syndrome in a patient with non hodgkin s lymphoma |
| url | http://dx.doi.org/10.1155/2015/979237 |
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