The Association between Single-Nucleotide Polymorphisms of ORAI1 Gene and Breast Cancer in a Taiwanese Population
Background. Breast cancer is the most common malignancy in women. There is increasing evidence suggesting that ORAI1, components of store-operated calcium channel, play a pivotal role in breast cancer progression and metastasis. Methods. A total of 384 female patients with breast cancer were include...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/916587 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560935914438656 |
|---|---|
| author | Wei-Chiao Chang Peng Yeong Woon Yu-Wen Hsu Shengyu Yang Yi-Ching Chiu Ming Feng Hou |
| author_facet | Wei-Chiao Chang Peng Yeong Woon Yu-Wen Hsu Shengyu Yang Yi-Ching Chiu Ming Feng Hou |
| author_sort | Wei-Chiao Chang |
| collection | DOAJ |
| description | Background. Breast cancer is the most common malignancy in women. There is increasing evidence suggesting that ORAI1, components of store-operated calcium channel, play a pivotal role in breast cancer progression and metastasis. Methods. A total of 384 female patients with breast cancer were included in this study. We selected five representative tagging ORAI1 SNPs from HapMap database with minimum allele frequency (MAF) >10%. Genotyping was performed using TaqMan allelic discrimination assay. Chi-square (χ2) test was used to analyze statistical differences among control and patient groups in genotype and allelic frequencies. Results. Two of the ORAI1 SNPs (rs12320939 and rs12313273) were associated with estrogen receptors positive in breast cancer patients under the recessive model. When the Bonferroni correction was performed, the significance still existed. In addition, rs12320939 also associated with the lymph nodal involvement. Conclusion. We showed that genetic polymorphisms of ORAI1 associated strongly with lymph nodal involvement and estrogen receptors (ERs) positive breast cancer patients in a Taiwanese population. |
| format | Article |
| id | doaj-art-317780a3bffa4fc6bce882e9005fcf79 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-317780a3bffa4fc6bce882e9005fcf792025-02-03T01:26:20ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/916587916587The Association between Single-Nucleotide Polymorphisms of ORAI1 Gene and Breast Cancer in a Taiwanese PopulationWei-Chiao Chang0Peng Yeong Woon1Yu-Wen Hsu2Shengyu Yang3Yi-Ching Chiu4Ming Feng Hou5Department of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Molecular Biology and Human Genetics, Tzu Chi University, Zhongyang Rd., Sec. 3, Hualien 97004, TaiwanDepartment of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Tumor Biology, Comprehensive Melanoma Research Center, H. Lee Moffitt Cancer Center, Tampa, FL 12902, USADepartment of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanInstitute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, 100 TzYou First Road, Kaohsiung 807, TaiwanBackground. Breast cancer is the most common malignancy in women. There is increasing evidence suggesting that ORAI1, components of store-operated calcium channel, play a pivotal role in breast cancer progression and metastasis. Methods. A total of 384 female patients with breast cancer were included in this study. We selected five representative tagging ORAI1 SNPs from HapMap database with minimum allele frequency (MAF) >10%. Genotyping was performed using TaqMan allelic discrimination assay. Chi-square (χ2) test was used to analyze statistical differences among control and patient groups in genotype and allelic frequencies. Results. Two of the ORAI1 SNPs (rs12320939 and rs12313273) were associated with estrogen receptors positive in breast cancer patients under the recessive model. When the Bonferroni correction was performed, the significance still existed. In addition, rs12320939 also associated with the lymph nodal involvement. Conclusion. We showed that genetic polymorphisms of ORAI1 associated strongly with lymph nodal involvement and estrogen receptors (ERs) positive breast cancer patients in a Taiwanese population.http://dx.doi.org/10.1100/2012/916587 |
| spellingShingle | Wei-Chiao Chang Peng Yeong Woon Yu-Wen Hsu Shengyu Yang Yi-Ching Chiu Ming Feng Hou The Association between Single-Nucleotide Polymorphisms of ORAI1 Gene and Breast Cancer in a Taiwanese Population The Scientific World Journal |
| title | The Association between Single-Nucleotide Polymorphisms of ORAI1 Gene and Breast Cancer in a Taiwanese Population |
| title_full | The Association between Single-Nucleotide Polymorphisms of ORAI1 Gene and Breast Cancer in a Taiwanese Population |
| title_fullStr | The Association between Single-Nucleotide Polymorphisms of ORAI1 Gene and Breast Cancer in a Taiwanese Population |
| title_full_unstemmed | The Association between Single-Nucleotide Polymorphisms of ORAI1 Gene and Breast Cancer in a Taiwanese Population |
| title_short | The Association between Single-Nucleotide Polymorphisms of ORAI1 Gene and Breast Cancer in a Taiwanese Population |
| title_sort | association between single nucleotide polymorphisms of orai1 gene and breast cancer in a taiwanese population |
| url | http://dx.doi.org/10.1100/2012/916587 |
| work_keys_str_mv | AT weichiaochang theassociationbetweensinglenucleotidepolymorphismsoforai1geneandbreastcancerinataiwanesepopulation AT pengyeongwoon theassociationbetweensinglenucleotidepolymorphismsoforai1geneandbreastcancerinataiwanesepopulation AT yuwenhsu theassociationbetweensinglenucleotidepolymorphismsoforai1geneandbreastcancerinataiwanesepopulation AT shengyuyang theassociationbetweensinglenucleotidepolymorphismsoforai1geneandbreastcancerinataiwanesepopulation AT yichingchiu theassociationbetweensinglenucleotidepolymorphismsoforai1geneandbreastcancerinataiwanesepopulation AT mingfenghou theassociationbetweensinglenucleotidepolymorphismsoforai1geneandbreastcancerinataiwanesepopulation AT weichiaochang associationbetweensinglenucleotidepolymorphismsoforai1geneandbreastcancerinataiwanesepopulation AT pengyeongwoon associationbetweensinglenucleotidepolymorphismsoforai1geneandbreastcancerinataiwanesepopulation AT yuwenhsu associationbetweensinglenucleotidepolymorphismsoforai1geneandbreastcancerinataiwanesepopulation AT shengyuyang associationbetweensinglenucleotidepolymorphismsoforai1geneandbreastcancerinataiwanesepopulation AT yichingchiu associationbetweensinglenucleotidepolymorphismsoforai1geneandbreastcancerinataiwanesepopulation AT mingfenghou associationbetweensinglenucleotidepolymorphismsoforai1geneandbreastcancerinataiwanesepopulation |