Drug-induced Leukocytoclastic Vasculitis Secondary to Trimethoprim/Sulfamethoxazole: A Case Report
Introduction: Leukocytoclastic vasculitis (LCV) is a small vessel vasculitis typically affecting dermal capillaries and venules. The condition is often idiopathic but can be associated with infections, neoplasms, autoimmune disorders, and certain drugs. Case Report: A 91-year-old female with past me...
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| Format: | Article |
| Language: | English |
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eScholarship Publishing, University of California
2025-01-01
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| Series: | Clinical Practice and Cases in Emergency Medicine |
| Online Access: | https://escholarship.org/uc/item/8j68w5fg |
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| author | Ambika Shivarajpur Simon Londono Justin Shaw Christopher Boccio Leonid Melnitsky Jheanelle McKay Brian Kohen Eric Boccio |
| author_facet | Ambika Shivarajpur Simon Londono Justin Shaw Christopher Boccio Leonid Melnitsky Jheanelle McKay Brian Kohen Eric Boccio |
| author_sort | Ambika Shivarajpur |
| collection | DOAJ |
| description | Introduction: Leukocytoclastic vasculitis (LCV) is a small vessel vasculitis typically affecting dermal capillaries and venules. The condition is often idiopathic but can be associated with infections, neoplasms, autoimmune disorders, and certain drugs. Case Report: A 91-year-old female with past medical history of Alzheimer dementia and hypertension, being treated for lower extremity cellulitis, presented to the emergency department for an allergic reaction. Trimethoprim/sulfamethoxazole (TMP/SMX) had been initiated six days earlier. The patient was noted to have normal vital signs. Palpable purpura was discovered on the lower back, buttocks, lower extremities, ankles, and feet. Laboratory studies were within normal limits. Given the clinical presentation, physical exam findings, and normal eosinophil count, the diagnosis of LCV secondary to TMP/SMX was made. Conclusion: Most cases of LCV are limited to cutaneous symptoms and self-resolve with supportive care. |
| format | Article |
| id | doaj-art-31631608355849b2af0f4f37abf556d8 |
| institution | Kabale University |
| issn | 2474-252X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | eScholarship Publishing, University of California |
| record_format | Article |
| series | Clinical Practice and Cases in Emergency Medicine |
| spelling | doaj-art-31631608355849b2af0f4f37abf556d82025-02-04T17:35:19ZengeScholarship Publishing, University of CaliforniaClinical Practice and Cases in Emergency Medicine2474-252X2025-01-0191616410.5811/cpcem.31056cpcem-9-61Drug-induced Leukocytoclastic Vasculitis Secondary to Trimethoprim/Sulfamethoxazole: A Case ReportAmbika Shivarajpur0Simon Londono1Justin Shaw2Christopher Boccio3Leonid Melnitsky4Jheanelle McKay5Brian Kohen6Eric Boccio7Memorial Healthcare System, Department of Emergency Medicine, Hollywood, FloridaMemorial Healthcare System, Department of Emergency Medicine, Hollywood, FloridaFlorida International University, Herbert Wertheim College of Medicine, Miami, FloridaNYC Health + Hospitals/Bellevue New York, Department of Pharmacy, New York, New YorkMemorial Healthcare System, Department of Emergency Medicine, Hollywood, FloridaJoe DiMaggio Children’s Hospital, Department of Pediatric Emergency Medicine, Hollywood, FloridaMemorial Healthcare System, Department of Emergency Medicine, Hollywood, FloridaMemorial Healthcare System, Department of Emergency Medicine, Hollywood, FloridaIntroduction: Leukocytoclastic vasculitis (LCV) is a small vessel vasculitis typically affecting dermal capillaries and venules. The condition is often idiopathic but can be associated with infections, neoplasms, autoimmune disorders, and certain drugs. Case Report: A 91-year-old female with past medical history of Alzheimer dementia and hypertension, being treated for lower extremity cellulitis, presented to the emergency department for an allergic reaction. Trimethoprim/sulfamethoxazole (TMP/SMX) had been initiated six days earlier. The patient was noted to have normal vital signs. Palpable purpura was discovered on the lower back, buttocks, lower extremities, ankles, and feet. Laboratory studies were within normal limits. Given the clinical presentation, physical exam findings, and normal eosinophil count, the diagnosis of LCV secondary to TMP/SMX was made. Conclusion: Most cases of LCV are limited to cutaneous symptoms and self-resolve with supportive care.https://escholarship.org/uc/item/8j68w5fg |
| spellingShingle | Ambika Shivarajpur Simon Londono Justin Shaw Christopher Boccio Leonid Melnitsky Jheanelle McKay Brian Kohen Eric Boccio Drug-induced Leukocytoclastic Vasculitis Secondary to Trimethoprim/Sulfamethoxazole: A Case Report Clinical Practice and Cases in Emergency Medicine |
| title | Drug-induced Leukocytoclastic Vasculitis Secondary to Trimethoprim/Sulfamethoxazole: A Case Report |
| title_full | Drug-induced Leukocytoclastic Vasculitis Secondary to Trimethoprim/Sulfamethoxazole: A Case Report |
| title_fullStr | Drug-induced Leukocytoclastic Vasculitis Secondary to Trimethoprim/Sulfamethoxazole: A Case Report |
| title_full_unstemmed | Drug-induced Leukocytoclastic Vasculitis Secondary to Trimethoprim/Sulfamethoxazole: A Case Report |
| title_short | Drug-induced Leukocytoclastic Vasculitis Secondary to Trimethoprim/Sulfamethoxazole: A Case Report |
| title_sort | drug induced leukocytoclastic vasculitis secondary to trimethoprim sulfamethoxazole a case report |
| url | https://escholarship.org/uc/item/8j68w5fg |
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