The effect of air pollution exposure on foetal growth restriction in pregnant women who conceived by in vitro fertilisation a cross-sectional study
Abstract Studies investigating the relationship between exposure to air pollutants during pregnancy and foetal growth restriction (FGR) in women who conceive by in vitro fertilisation (IVF) are lacking. The objective was to investigate the effect of air pollutant exposure in pregnancy on FGR in preg...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-87955-z |
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| author | Yanqiong Jiang Pengfei Liu Meihong Zeng Guiying Zhuang Cuiqing Qiu Liyun Wang Weiling Liu Weiqi Liu |
| author_facet | Yanqiong Jiang Pengfei Liu Meihong Zeng Guiying Zhuang Cuiqing Qiu Liyun Wang Weiling Liu Weiqi Liu |
| author_sort | Yanqiong Jiang |
| collection | DOAJ |
| description | Abstract Studies investigating the relationship between exposure to air pollutants during pregnancy and foetal growth restriction (FGR) in women who conceive by in vitro fertilisation (IVF) are lacking. The objective was to investigate the effect of air pollutant exposure in pregnancy on FGR in pregnant women who conceive by IVF. We included pregnant women who conceived by IVF and delivered healthy singleton babies in Guangzhou from October 2018 to September 2023. We also collected data on air pollutant concentrations in Guangzhou during the same period. We analysed the impact of air pollution exposure during pregnancy on FGR. After adjusting for confounders, our analysis showed that in the first trimester, high concentrations of PM10 and NO2 in the fourth quartile significantly increased the risk of FGR. Specifically, the odds ratios were 6.430 (95% confidence interval [CI]: 1.035–39.96) for PM10 and 10.73 (95% CI: 1.230–93.48) for NO2. In the second trimester, exposure to PM2.5, PM10, and NO2 was associated with an increased risk of FGR. In addition, subgroup analyses showed that exposure to NO2 during pregnancy increased the risk of FGR in women aged 35 years and older. The results of this cross-sectional study suggest that exposure to PM2.5, PM10, and NO2 in pregnant women who conceive by IVF is associated with the occurrence of FGR. |
| format | Article |
| id | doaj-art-3158d4c11b1f484487f5382897b58b62 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-3158d4c11b1f484487f5382897b58b622025-02-02T12:17:13ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-025-87955-zThe effect of air pollution exposure on foetal growth restriction in pregnant women who conceived by in vitro fertilisation a cross-sectional studyYanqiong Jiang0Pengfei Liu1Meihong Zeng2Guiying Zhuang3Cuiqing Qiu4Liyun Wang5Weiling Liu6Weiqi Liu7Division of Neonatology, The Maternal and Children Health Care Hospital (Huzhong Hospital) of HuaduDepartment of Laboratory Medicine, The Third Affiliated Hospital of Southern Medical University, Southern Medical UniversityDivision of Neonatology, The Maternal and Children Health Care Hospital (Huzhong Hospital) of HuaduDivision of Neonatology, The Maternal and Children Health Care Hospital (Huzhong Hospital) of HuaduMedical Information Office, The Maternal and Children Health Care Hospital (Huzhong Hospital) of HuaduReproductive Medicine Department, The Maternal and Children Health Care Hospital (Huzhong Hospital) of HuaduDepartment of Clinical Laboratory, Foshan Fosun Chancheng HospitalDepartment of Clinical Laboratory, The Maternal and Children Health Care Hospital (Huzhong Hospital) of HuaduAbstract Studies investigating the relationship between exposure to air pollutants during pregnancy and foetal growth restriction (FGR) in women who conceive by in vitro fertilisation (IVF) are lacking. The objective was to investigate the effect of air pollutant exposure in pregnancy on FGR in pregnant women who conceive by IVF. We included pregnant women who conceived by IVF and delivered healthy singleton babies in Guangzhou from October 2018 to September 2023. We also collected data on air pollutant concentrations in Guangzhou during the same period. We analysed the impact of air pollution exposure during pregnancy on FGR. After adjusting for confounders, our analysis showed that in the first trimester, high concentrations of PM10 and NO2 in the fourth quartile significantly increased the risk of FGR. Specifically, the odds ratios were 6.430 (95% confidence interval [CI]: 1.035–39.96) for PM10 and 10.73 (95% CI: 1.230–93.48) for NO2. In the second trimester, exposure to PM2.5, PM10, and NO2 was associated with an increased risk of FGR. In addition, subgroup analyses showed that exposure to NO2 during pregnancy increased the risk of FGR in women aged 35 years and older. The results of this cross-sectional study suggest that exposure to PM2.5, PM10, and NO2 in pregnant women who conceive by IVF is associated with the occurrence of FGR.https://doi.org/10.1038/s41598-025-87955-zAir pollutantsFoetal growth restrictionIn vitro fertilisationPregnant women |
| spellingShingle | Yanqiong Jiang Pengfei Liu Meihong Zeng Guiying Zhuang Cuiqing Qiu Liyun Wang Weiling Liu Weiqi Liu The effect of air pollution exposure on foetal growth restriction in pregnant women who conceived by in vitro fertilisation a cross-sectional study Scientific Reports Air pollutants Foetal growth restriction In vitro fertilisation Pregnant women |
| title | The effect of air pollution exposure on foetal growth restriction in pregnant women who conceived by in vitro fertilisation a cross-sectional study |
| title_full | The effect of air pollution exposure on foetal growth restriction in pregnant women who conceived by in vitro fertilisation a cross-sectional study |
| title_fullStr | The effect of air pollution exposure on foetal growth restriction in pregnant women who conceived by in vitro fertilisation a cross-sectional study |
| title_full_unstemmed | The effect of air pollution exposure on foetal growth restriction in pregnant women who conceived by in vitro fertilisation a cross-sectional study |
| title_short | The effect of air pollution exposure on foetal growth restriction in pregnant women who conceived by in vitro fertilisation a cross-sectional study |
| title_sort | effect of air pollution exposure on foetal growth restriction in pregnant women who conceived by in vitro fertilisation a cross sectional study |
| topic | Air pollutants Foetal growth restriction In vitro fertilisation Pregnant women |
| url | https://doi.org/10.1038/s41598-025-87955-z |
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