The effect of air pollution exposure on foetal growth restriction in pregnant women who conceived by in vitro fertilisation a cross-sectional study
Abstract Studies investigating the relationship between exposure to air pollutants during pregnancy and foetal growth restriction (FGR) in women who conceive by in vitro fertilisation (IVF) are lacking. The objective was to investigate the effect of air pollutant exposure in pregnancy on FGR in preg...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-87955-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Abstract Studies investigating the relationship between exposure to air pollutants during pregnancy and foetal growth restriction (FGR) in women who conceive by in vitro fertilisation (IVF) are lacking. The objective was to investigate the effect of air pollutant exposure in pregnancy on FGR in pregnant women who conceive by IVF. We included pregnant women who conceived by IVF and delivered healthy singleton babies in Guangzhou from October 2018 to September 2023. We also collected data on air pollutant concentrations in Guangzhou during the same period. We analysed the impact of air pollution exposure during pregnancy on FGR. After adjusting for confounders, our analysis showed that in the first trimester, high concentrations of PM10 and NO2 in the fourth quartile significantly increased the risk of FGR. Specifically, the odds ratios were 6.430 (95% confidence interval [CI]: 1.035–39.96) for PM10 and 10.73 (95% CI: 1.230–93.48) for NO2. In the second trimester, exposure to PM2.5, PM10, and NO2 was associated with an increased risk of FGR. In addition, subgroup analyses showed that exposure to NO2 during pregnancy increased the risk of FGR in women aged 35 years and older. The results of this cross-sectional study suggest that exposure to PM2.5, PM10, and NO2 in pregnant women who conceive by IVF is associated with the occurrence of FGR. |
|---|---|
| ISSN: | 2045-2322 |