Synthesis of Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole and Its Analgesic, Anti-Inflammatory and Anti-Bacterial Activity
Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole derivatives have been synthesized with different aromatic aldehyde. 1,3,4-thiadiazole derivatives were prepared by the reaction of thiosemicarbazide, sodium acetate and aromatic aldehyde. The structures of the titled Schiff bases were elucidated by IR...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2012/145028 |
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| author | Alok Pandey R. Rajavel Sandeep Chandraker Deepak Dash |
| author_facet | Alok Pandey R. Rajavel Sandeep Chandraker Deepak Dash |
| author_sort | Alok Pandey |
| collection | DOAJ |
| description | Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole derivatives have been synthesized with different aromatic aldehyde. 1,3,4-thiadiazole derivatives were prepared by the reaction of thiosemicarbazide, sodium acetate and aromatic aldehyde. The structures of the titled Schiff bases were elucidated by IR and 1H NMR spectral measurements. All the compounds were evaluated for their analgesic activity against swiss albino mice, anti-inflammatory activity against Wister albino rats. The compounds showed significant antibacterial activity against Staphylococcus aureus (gram-positive) bacteria and E. coli (gram-negative) bacteria. |
| format | Article |
| id | doaj-art-314077b99e074cd58ef439b8f79d112e |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-314077b99e074cd58ef439b8f79d112e2025-02-03T05:46:22ZengWileyE-Journal of Chemistry0973-49452090-98102012-01-01942524253110.1155/2012/145028Synthesis of Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole and Its Analgesic, Anti-Inflammatory and Anti-Bacterial ActivityAlok Pandey0R. Rajavel1Sandeep Chandraker2Deepak Dash3Department of Pharmaceutical Chemistry, Nandha College of Pharmacy and Research Institute, Erode-52 Tamilnandu, IndiaDepartment of Pharmaceutical Chemistry, Nandha College of Pharmacy and Research Institute, Erode-52 Tamilnandu, IndiaRoyal College of Pharmacy Science Raipur, (C.G.) 492101, IndiaRoyal College of Pharmacy Science Raipur, (C.G.) 492101, IndiaSchiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole derivatives have been synthesized with different aromatic aldehyde. 1,3,4-thiadiazole derivatives were prepared by the reaction of thiosemicarbazide, sodium acetate and aromatic aldehyde. The structures of the titled Schiff bases were elucidated by IR and 1H NMR spectral measurements. All the compounds were evaluated for their analgesic activity against swiss albino mice, anti-inflammatory activity against Wister albino rats. The compounds showed significant antibacterial activity against Staphylococcus aureus (gram-positive) bacteria and E. coli (gram-negative) bacteria.http://dx.doi.org/10.1155/2012/145028 |
| spellingShingle | Alok Pandey R. Rajavel Sandeep Chandraker Deepak Dash Synthesis of Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole and Its Analgesic, Anti-Inflammatory and Anti-Bacterial Activity E-Journal of Chemistry |
| title | Synthesis of Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole and Its Analgesic, Anti-Inflammatory and Anti-Bacterial Activity |
| title_full | Synthesis of Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole and Its Analgesic, Anti-Inflammatory and Anti-Bacterial Activity |
| title_fullStr | Synthesis of Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole and Its Analgesic, Anti-Inflammatory and Anti-Bacterial Activity |
| title_full_unstemmed | Synthesis of Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole and Its Analgesic, Anti-Inflammatory and Anti-Bacterial Activity |
| title_short | Synthesis of Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole and Its Analgesic, Anti-Inflammatory and Anti-Bacterial Activity |
| title_sort | synthesis of schiff bases of 2 amino 5 aryl 1 3 4 thiadiazole and its analgesic anti inflammatory and anti bacterial activity |
| url | http://dx.doi.org/10.1155/2012/145028 |
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