Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar
Objectives. To explore the effective and safe medicines for treating diabetes. Methods. Hydroalcoholic extracts of 130 medicinal plants belonging to 66 families were evaluated using porcine pancreatic lipase (PPL) inhibition and glucose uptake methods together with a literature review. Results. The...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2021/1424675 |
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| author | Dongdong Zhang Karuppusamy Arunachalam Yuehu Wang Yu Zhang Jun Yang Pyae Phyo Hein Aye Mya Mon Jianwen Li Angkhana Inta Xuefei Yang |
| author_facet | Dongdong Zhang Karuppusamy Arunachalam Yuehu Wang Yu Zhang Jun Yang Pyae Phyo Hein Aye Mya Mon Jianwen Li Angkhana Inta Xuefei Yang |
| author_sort | Dongdong Zhang |
| collection | DOAJ |
| description | Objectives. To explore the effective and safe medicines for treating diabetes. Methods. Hydroalcoholic extracts of 130 medicinal plants belonging to 66 families were evaluated using porcine pancreatic lipase (PPL) inhibition and glucose uptake methods together with a literature review. Results. The extracts of 22 species showed the PPL inhibition activity; 18 extracts of 15 species stimulated glucose uptake in 3T3-L1 adipocytes. Among them, Mansonia gagei J.R. Drumm., Mesua ferrea L., and Centella asiatica (L.) Urb. exhibited both activities. The extracts of Caladium lindenii (André) Madison rhizomes and Azadirachta indica A. Juss. leaves presented the utmost lipase inhibitory activity with IC50 of 6.86 ± 0.25 and 11.46 ± 0.06 μg/mL, respectively. The extracts of Coptis teeta Wall. rhizomes and Croton tiglium L. seeds stimulated the maximum glucose uptake. Ten species are reported to have antidiabetic activity for the first time. Flavonoids and triterpenoids are the dominant antidiabetic compounds in selected medicinal plants from Myanmar. Conclusions. P. zeylanica, L. cubeba, H. crenulate, M. gagei, C. teeta, and M. ferrea are worthy to advance further study according to their strong antidiabetic activities and limited research on effects in in vivo animal studies, unclear chemical constitutes, and safety. |
| format | Article |
| id | doaj-art-31348334837a47689e77591a9466e7b7 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-31348334837a47689e77591a9466e7b72025-02-03T00:59:06ZengWileyThe Scientific World Journal2356-61401537-744X2021-01-01202110.1155/2021/14246751424675Evaluation on Antidiabetic Properties of Medicinal Plants from MyanmarDongdong Zhang0Karuppusamy Arunachalam1Yuehu Wang2Yu Zhang3Jun Yang4Pyae Phyo Hein5Aye Mya Mon6Jianwen Li7Angkhana Inta8Xuefei Yang9Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaKey Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaKey Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaKey Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaKey Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaKey Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaKey Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaKey Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaDepartment of Biology, Faculty of Science, Chiang Mai University, 239 Huay Kaew Road, Chiang Mai 50200, ThailandKey Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, ChinaObjectives. To explore the effective and safe medicines for treating diabetes. Methods. Hydroalcoholic extracts of 130 medicinal plants belonging to 66 families were evaluated using porcine pancreatic lipase (PPL) inhibition and glucose uptake methods together with a literature review. Results. The extracts of 22 species showed the PPL inhibition activity; 18 extracts of 15 species stimulated glucose uptake in 3T3-L1 adipocytes. Among them, Mansonia gagei J.R. Drumm., Mesua ferrea L., and Centella asiatica (L.) Urb. exhibited both activities. The extracts of Caladium lindenii (André) Madison rhizomes and Azadirachta indica A. Juss. leaves presented the utmost lipase inhibitory activity with IC50 of 6.86 ± 0.25 and 11.46 ± 0.06 μg/mL, respectively. The extracts of Coptis teeta Wall. rhizomes and Croton tiglium L. seeds stimulated the maximum glucose uptake. Ten species are reported to have antidiabetic activity for the first time. Flavonoids and triterpenoids are the dominant antidiabetic compounds in selected medicinal plants from Myanmar. Conclusions. P. zeylanica, L. cubeba, H. crenulate, M. gagei, C. teeta, and M. ferrea are worthy to advance further study according to their strong antidiabetic activities and limited research on effects in in vivo animal studies, unclear chemical constitutes, and safety.http://dx.doi.org/10.1155/2021/1424675 |
| spellingShingle | Dongdong Zhang Karuppusamy Arunachalam Yuehu Wang Yu Zhang Jun Yang Pyae Phyo Hein Aye Mya Mon Jianwen Li Angkhana Inta Xuefei Yang Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar The Scientific World Journal |
| title | Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar |
| title_full | Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar |
| title_fullStr | Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar |
| title_full_unstemmed | Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar |
| title_short | Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar |
| title_sort | evaluation on antidiabetic properties of medicinal plants from myanmar |
| url | http://dx.doi.org/10.1155/2021/1424675 |
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