Inhalation Induced Stresses and Flow Characteristics in Human Airways through Fluid-Structure Interaction Analysis
Better understanding of stresses and flow characteristics in the human airways is very important for many clinical applications such as aerosol drug therapy, inhalation toxicology, and airway remodeling process. The bifurcation geometry of airway generations 3 to 5 based on the ICRP tracheobronchial...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Modelling and Simulation in Engineering |
| Online Access: | http://dx.doi.org/10.1155/2008/358748 |
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| author | Kittisak Koombua Ramana M. Pidaparti |
| author_facet | Kittisak Koombua Ramana M. Pidaparti |
| author_sort | Kittisak Koombua |
| collection | DOAJ |
| description | Better understanding of stresses and flow characteristics in the human airways is very important for many clinical applications such as aerosol drug therapy, inhalation toxicology, and airway remodeling process. The bifurcation geometry of airway generations 3 to 5 based on the ICRP tracheobronchial model was chosen to analyze the flow characteristics and stresses during inhalation. A computational model was developed to investigate the airway tissue flexibility effect on stresses and flow characteristics in the airways. The finite-element method with the fluid-structure interaction analysis was employed to investigate the transient responses of the flow characteristics and stresses in the airways during inhalation. The simulation results showed that tissue flexibility affected the maximum airflow velocity, airway pressure, and wall shear stress about 2%, 7%, and 6%, respectively. The simulation results also showed that the differences between the orthotropic and isotropic material models on the airway stresses were in the ranges of 25–52%. The results from the present study suggest that it is very important to incorporate the orthotropic tissue properties into a computational model for studying flow characteristics and stresses in the airways. |
| format | Article |
| id | doaj-art-3127ca8bad2446c8b935df60f10dddb7 |
| institution | Kabale University |
| issn | 1687-5591 1687-5605 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Modelling and Simulation in Engineering |
| spelling | doaj-art-3127ca8bad2446c8b935df60f10dddb72025-02-03T05:46:22ZengWileyModelling and Simulation in Engineering1687-55911687-56052008-01-01200810.1155/2008/358748358748Inhalation Induced Stresses and Flow Characteristics in Human Airways through Fluid-Structure Interaction AnalysisKittisak Koombua0Ramana M. Pidaparti1Department of Mechanical Engineering, Virginia Commonwealth University, Richmond, VA 23284, USADepartment of Mechanical Engineering, Virginia Commonwealth University, Richmond, VA 23284, USABetter understanding of stresses and flow characteristics in the human airways is very important for many clinical applications such as aerosol drug therapy, inhalation toxicology, and airway remodeling process. The bifurcation geometry of airway generations 3 to 5 based on the ICRP tracheobronchial model was chosen to analyze the flow characteristics and stresses during inhalation. A computational model was developed to investigate the airway tissue flexibility effect on stresses and flow characteristics in the airways. The finite-element method with the fluid-structure interaction analysis was employed to investigate the transient responses of the flow characteristics and stresses in the airways during inhalation. The simulation results showed that tissue flexibility affected the maximum airflow velocity, airway pressure, and wall shear stress about 2%, 7%, and 6%, respectively. The simulation results also showed that the differences between the orthotropic and isotropic material models on the airway stresses were in the ranges of 25–52%. The results from the present study suggest that it is very important to incorporate the orthotropic tissue properties into a computational model for studying flow characteristics and stresses in the airways.http://dx.doi.org/10.1155/2008/358748 |
| spellingShingle | Kittisak Koombua Ramana M. Pidaparti Inhalation Induced Stresses and Flow Characteristics in Human Airways through Fluid-Structure Interaction Analysis Modelling and Simulation in Engineering |
| title | Inhalation Induced Stresses and Flow Characteristics in Human Airways through Fluid-Structure Interaction Analysis |
| title_full | Inhalation Induced Stresses and Flow Characteristics in Human Airways through Fluid-Structure Interaction Analysis |
| title_fullStr | Inhalation Induced Stresses and Flow Characteristics in Human Airways through Fluid-Structure Interaction Analysis |
| title_full_unstemmed | Inhalation Induced Stresses and Flow Characteristics in Human Airways through Fluid-Structure Interaction Analysis |
| title_short | Inhalation Induced Stresses and Flow Characteristics in Human Airways through Fluid-Structure Interaction Analysis |
| title_sort | inhalation induced stresses and flow characteristics in human airways through fluid structure interaction analysis |
| url | http://dx.doi.org/10.1155/2008/358748 |
| work_keys_str_mv | AT kittisakkoombua inhalationinducedstressesandflowcharacteristicsinhumanairwaysthroughfluidstructureinteractionanalysis AT ramanampidaparti inhalationinducedstressesandflowcharacteristicsinhumanairwaysthroughfluidstructureinteractionanalysis |