Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy
Sensorineural hearing loss (SNHL) becomes an inevitable worldwide public health issue, and deafness treatment is urgently imperative; yet their current curative therapy is limited. Auditory neuropathies (AN) were proved to play a substantial role in SNHL recently, and spiral ganglion neuron (SGN) dy...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2020/8843485 |
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| author | Baoyi Feng Chenxi Jin Zhenzhe Cheng Xingle Zhao Zhuoer Sun Xiaofei Zheng Xiang Li Tingting Dong Yong Tao Hao Wu |
| author_facet | Baoyi Feng Chenxi Jin Zhenzhe Cheng Xingle Zhao Zhuoer Sun Xiaofei Zheng Xiang Li Tingting Dong Yong Tao Hao Wu |
| author_sort | Baoyi Feng |
| collection | DOAJ |
| description | Sensorineural hearing loss (SNHL) becomes an inevitable worldwide public health issue, and deafness treatment is urgently imperative; yet their current curative therapy is limited. Auditory neuropathies (AN) were proved to play a substantial role in SNHL recently, and spiral ganglion neuron (SGN) dysfunction is a dominant pathogenesis of AN. Auditory pathway is a high energy consumption system, and SGNs required sufficient mitochondria. Mitochondria are known treatment target of SNHL, but mitochondrion mechanism and pathology in SGNs are not valued. Mitochondrial dysfunction and pharmacological therapy were studied in neurodegeneration, providing new insights in mitochondrion-targeted treatment of AN. In this review, we summarized mitochondrial biological functions related to SGNs and discussed interaction between mitochondrial dysfunction and AN, as well as existing mitochondrion treatment for SNHL. Pharmaceutical exploration to protect mitochondrion dysfunction is a feasible and effective therapeutics for AN. |
| format | Article |
| id | doaj-art-3126b62aa6fc4f688c976baedd99754a |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-3126b62aa6fc4f688c976baedd99754a2025-02-03T06:04:36ZengWileyNeural Plasticity2090-59041687-54432020-01-01202010.1155/2020/88434858843485Mitochondrial Dysfunction and Therapeutic Targets in Auditory NeuropathyBaoyi Feng0Chenxi Jin1Zhenzhe Cheng2Xingle Zhao3Zhuoer Sun4Xiaofei Zheng5Xiang Li6Tingting Dong7Yong Tao8Hao Wu9Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, Shanghai 200011, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, Shanghai 200011, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, Shanghai 200011, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, Shanghai 200011, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, Shanghai 200011, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, Shanghai 200011, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, Shanghai 200011, ChinaBiobank of Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, No. 115, Jinzun Road, Shanghai 200011, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, Shanghai 200011, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, Shanghai 200011, ChinaSensorineural hearing loss (SNHL) becomes an inevitable worldwide public health issue, and deafness treatment is urgently imperative; yet their current curative therapy is limited. Auditory neuropathies (AN) were proved to play a substantial role in SNHL recently, and spiral ganglion neuron (SGN) dysfunction is a dominant pathogenesis of AN. Auditory pathway is a high energy consumption system, and SGNs required sufficient mitochondria. Mitochondria are known treatment target of SNHL, but mitochondrion mechanism and pathology in SGNs are not valued. Mitochondrial dysfunction and pharmacological therapy were studied in neurodegeneration, providing new insights in mitochondrion-targeted treatment of AN. In this review, we summarized mitochondrial biological functions related to SGNs and discussed interaction between mitochondrial dysfunction and AN, as well as existing mitochondrion treatment for SNHL. Pharmaceutical exploration to protect mitochondrion dysfunction is a feasible and effective therapeutics for AN.http://dx.doi.org/10.1155/2020/8843485 |
| spellingShingle | Baoyi Feng Chenxi Jin Zhenzhe Cheng Xingle Zhao Zhuoer Sun Xiaofei Zheng Xiang Li Tingting Dong Yong Tao Hao Wu Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy Neural Plasticity |
| title | Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy |
| title_full | Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy |
| title_fullStr | Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy |
| title_full_unstemmed | Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy |
| title_short | Mitochondrial Dysfunction and Therapeutic Targets in Auditory Neuropathy |
| title_sort | mitochondrial dysfunction and therapeutic targets in auditory neuropathy |
| url | http://dx.doi.org/10.1155/2020/8843485 |
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