Association Between Uric Acid to High‐Density Lipoprotein Cholesterol Ratio and Kidney Function in Patients With Primary Aldosteronism: A Cross‐Sectional Study
ABSTRACT The relationship between the uric acid to high‐density lipoprotein cholesterol ratio (UHR) and kidney function in patients with primary aldosteronism (PA) is unclear. Therefore, this research explored the link between the UHR and kidney function in PAs. This research was conducted at the 2n...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | The Journal of Clinical Hypertension |
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| Online Access: | https://doi.org/10.1111/jch.14960 |
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| author | Meng‐Bo Wu Rui Wang Qing‐Tian Zeng Wen‐Liang Shuai Hang‐Cheng Zhang Yi‐Fei Dong |
| author_facet | Meng‐Bo Wu Rui Wang Qing‐Tian Zeng Wen‐Liang Shuai Hang‐Cheng Zhang Yi‐Fei Dong |
| author_sort | Meng‐Bo Wu |
| collection | DOAJ |
| description | ABSTRACT The relationship between the uric acid to high‐density lipoprotein cholesterol ratio (UHR) and kidney function in patients with primary aldosteronism (PA) is unclear. Therefore, this research explored the link between the UHR and kidney function in PAs. This research was conducted at the 2nd Affiliated Hospital of Nanchang University and involved PA individuals hospitalized between October 2017 and April 2022. A total of 653 eligible participants were included in the analysis for this research. The kidney function was assessed by the estimated glomerular filtration rate (eGFR), which is calculated using the modification of diet in renal disease (MDRD) equation. Chronic kidney disease (CKD) was defined as an eGFR <60 mL/min per 1.73 m2 or the ratio of urine microalbumin to creatinine (UACR) ≥30 mg/g. The study used multivariable‐adjusted linear regression analyses to investigate the association between log‐transformed UHR levels and, eGFR and CKD. After multivariable adjustments, the results indicated an inverse association between Lg‐UHR and eGFR (per SD increment; β: −9.02; 95% CI: −11.59, −6.46). Compared to PA patients with the lowest level of Lg‐UHR (T1), patients with the highest level of Lg‐UHR (T3) had a lower eGFR (β: −20.14, 95% CI: −26.25, −14.04). Conversely, Lg‐UHR and CKD showed a positive association cross‐sectionally (per SD increment; OR: 1.67; 95% CI: 1.26, 2.23). Compared to PA patients in T1 level, patients in T3 level had a higher prevalence of CKD (OR: 2.52, 95% CI: 1.26, 5.05). In patients with PA, UHR is inversely associated with eGFR and positively associated with CKD. |
| format | Article |
| id | doaj-art-3120554ff8b2421f93a2915a46bd34c1 |
| institution | Kabale University |
| issn | 1524-6175 1751-7176 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | The Journal of Clinical Hypertension |
| spelling | doaj-art-3120554ff8b2421f93a2915a46bd34c12025-01-31T05:38:36ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762025-01-01271n/an/a10.1111/jch.14960Association Between Uric Acid to High‐Density Lipoprotein Cholesterol Ratio and Kidney Function in Patients With Primary Aldosteronism: A Cross‐Sectional StudyMeng‐Bo Wu0Rui Wang1Qing‐Tian Zeng2Wen‐Liang Shuai3Hang‐Cheng Zhang4Yi‐Fei Dong5Department of Cardiovascular Medicine the 2nd Affiliated Hospital Jiangxi Medical College Nanchang University Nanchang Jiangxi ChinaDepartment of Cardiovascular Medicine the 2nd Affiliated Hospital Jiangxi Medical College Nanchang University Nanchang Jiangxi ChinaDepartment of Cardiovascular Medicine the 2nd Affiliated Hospital Jiangxi Medical College Nanchang University Nanchang Jiangxi ChinaDepartment of Cardiovascular Medicine the 2nd Affiliated Hospital Jiangxi Medical College Nanchang University Nanchang Jiangxi ChinaDepartment of Cardiovascular Medicine the 2nd Affiliated Hospital Jiangxi Medical College Nanchang University Nanchang Jiangxi ChinaDepartment of Cardiovascular Medicine the 2nd Affiliated Hospital Jiangxi Medical College Nanchang University Nanchang Jiangxi ChinaABSTRACT The relationship between the uric acid to high‐density lipoprotein cholesterol ratio (UHR) and kidney function in patients with primary aldosteronism (PA) is unclear. Therefore, this research explored the link between the UHR and kidney function in PAs. This research was conducted at the 2nd Affiliated Hospital of Nanchang University and involved PA individuals hospitalized between October 2017 and April 2022. A total of 653 eligible participants were included in the analysis for this research. The kidney function was assessed by the estimated glomerular filtration rate (eGFR), which is calculated using the modification of diet in renal disease (MDRD) equation. Chronic kidney disease (CKD) was defined as an eGFR <60 mL/min per 1.73 m2 or the ratio of urine microalbumin to creatinine (UACR) ≥30 mg/g. The study used multivariable‐adjusted linear regression analyses to investigate the association between log‐transformed UHR levels and, eGFR and CKD. After multivariable adjustments, the results indicated an inverse association between Lg‐UHR and eGFR (per SD increment; β: −9.02; 95% CI: −11.59, −6.46). Compared to PA patients with the lowest level of Lg‐UHR (T1), patients with the highest level of Lg‐UHR (T3) had a lower eGFR (β: −20.14, 95% CI: −26.25, −14.04). Conversely, Lg‐UHR and CKD showed a positive association cross‐sectionally (per SD increment; OR: 1.67; 95% CI: 1.26, 2.23). Compared to PA patients in T1 level, patients in T3 level had a higher prevalence of CKD (OR: 2.52, 95% CI: 1.26, 5.05). In patients with PA, UHR is inversely associated with eGFR and positively associated with CKD.https://doi.org/10.1111/jch.14960chronic kidney diseasehigh‐density lipoprotein cholesterolkidney functionprimary aldosteronismuric acid |
| spellingShingle | Meng‐Bo Wu Rui Wang Qing‐Tian Zeng Wen‐Liang Shuai Hang‐Cheng Zhang Yi‐Fei Dong Association Between Uric Acid to High‐Density Lipoprotein Cholesterol Ratio and Kidney Function in Patients With Primary Aldosteronism: A Cross‐Sectional Study The Journal of Clinical Hypertension chronic kidney disease high‐density lipoprotein cholesterol kidney function primary aldosteronism uric acid |
| title | Association Between Uric Acid to High‐Density Lipoprotein Cholesterol Ratio and Kidney Function in Patients With Primary Aldosteronism: A Cross‐Sectional Study |
| title_full | Association Between Uric Acid to High‐Density Lipoprotein Cholesterol Ratio and Kidney Function in Patients With Primary Aldosteronism: A Cross‐Sectional Study |
| title_fullStr | Association Between Uric Acid to High‐Density Lipoprotein Cholesterol Ratio and Kidney Function in Patients With Primary Aldosteronism: A Cross‐Sectional Study |
| title_full_unstemmed | Association Between Uric Acid to High‐Density Lipoprotein Cholesterol Ratio and Kidney Function in Patients With Primary Aldosteronism: A Cross‐Sectional Study |
| title_short | Association Between Uric Acid to High‐Density Lipoprotein Cholesterol Ratio and Kidney Function in Patients With Primary Aldosteronism: A Cross‐Sectional Study |
| title_sort | association between uric acid to high density lipoprotein cholesterol ratio and kidney function in patients with primary aldosteronism a cross sectional study |
| topic | chronic kidney disease high‐density lipoprotein cholesterol kidney function primary aldosteronism uric acid |
| url | https://doi.org/10.1111/jch.14960 |
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