Congenital Oligodendroglioma: Clinicopathologic and Molecular Assessment with Review of the Literature
Oligodendroglioma is an infiltrating glial neoplasm frequently seen in adults. Pediatric oligodendrogliomas are rare, with very few cases presenting in infancy and only rare congenital examples. In contrast to adult oligodendrogliomas, pediatric cases typically lack 1p/19q codeletion. Herein we repo...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2015/370234 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564739557818368 |
|---|---|
| author | Hope Richard Kimberly Stogner-Underwood Christine Fuller |
| author_facet | Hope Richard Kimberly Stogner-Underwood Christine Fuller |
| author_sort | Hope Richard |
| collection | DOAJ |
| description | Oligodendroglioma is an infiltrating glial neoplasm frequently seen in adults. Pediatric oligodendrogliomas are rare, with very few cases presenting in infancy and only rare congenital examples. In contrast to adult oligodendrogliomas, pediatric cases typically lack 1p/19q codeletion. Herein we report a case of WHO grade II oligodendroglioma diagnosed in a 7-month-old male infant. The patient initially presented at 3 months of age with symptoms suspicious for seizure. Initial workup including electroencephalography (EEG), electrocardiogram (EKG), and computed tomography (CT) of the head was negative. His symptoms persisted, and subsequent magnetic resonance imaging (MRI) performed at age of 7 months revealed a 2 cm contrast-enhancing left temporal lobe mass. The mass was excised and the microscopic appearance was that of a classic low grade oligodendroglioma composed of cells with uniformly round nuclei, perinuclear halos, delicate branching capillaries, and an absence of high grade features. Mutant specific (R132H) isocitrate dehydrogenase-1 (IDH1) immunohistochemistry was negative, and the tumor lacked detectable 1p or 19q deletions by fluorescent in situ hybridization (FISH). The onset of neurological symptoms in early infancy followed by the positive MRI findings suggests that this case represents a rare example of congenital oligodendroglioma. |
| format | Article |
| id | doaj-art-31094776a0284c67ba2ed3c5c8d5da6c |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-31094776a0284c67ba2ed3c5c8d5da6c2025-02-03T01:10:19ZengWileyCase Reports in Pathology2090-67812090-679X2015-01-01201510.1155/2015/370234370234Congenital Oligodendroglioma: Clinicopathologic and Molecular Assessment with Review of the LiteratureHope Richard0Kimberly Stogner-Underwood1Christine Fuller2Department of Pathology, Virginia Commonwealth University Health System, 1101 E. Marshall Street, P.O. Box 980662, Richmond, VA 23298, USADepartment of Pathology, Virginia Commonwealth University Health System, 1101 E. Marshall Street, P.O. Box 980662, Richmond, VA 23298, USADepartment of Pathology, Virginia Commonwealth University Health System, 1101 E. Marshall Street, P.O. Box 980662, Richmond, VA 23298, USAOligodendroglioma is an infiltrating glial neoplasm frequently seen in adults. Pediatric oligodendrogliomas are rare, with very few cases presenting in infancy and only rare congenital examples. In contrast to adult oligodendrogliomas, pediatric cases typically lack 1p/19q codeletion. Herein we report a case of WHO grade II oligodendroglioma diagnosed in a 7-month-old male infant. The patient initially presented at 3 months of age with symptoms suspicious for seizure. Initial workup including electroencephalography (EEG), electrocardiogram (EKG), and computed tomography (CT) of the head was negative. His symptoms persisted, and subsequent magnetic resonance imaging (MRI) performed at age of 7 months revealed a 2 cm contrast-enhancing left temporal lobe mass. The mass was excised and the microscopic appearance was that of a classic low grade oligodendroglioma composed of cells with uniformly round nuclei, perinuclear halos, delicate branching capillaries, and an absence of high grade features. Mutant specific (R132H) isocitrate dehydrogenase-1 (IDH1) immunohistochemistry was negative, and the tumor lacked detectable 1p or 19q deletions by fluorescent in situ hybridization (FISH). The onset of neurological symptoms in early infancy followed by the positive MRI findings suggests that this case represents a rare example of congenital oligodendroglioma.http://dx.doi.org/10.1155/2015/370234 |
| spellingShingle | Hope Richard Kimberly Stogner-Underwood Christine Fuller Congenital Oligodendroglioma: Clinicopathologic and Molecular Assessment with Review of the Literature Case Reports in Pathology |
| title | Congenital Oligodendroglioma: Clinicopathologic and Molecular Assessment with Review of the Literature |
| title_full | Congenital Oligodendroglioma: Clinicopathologic and Molecular Assessment with Review of the Literature |
| title_fullStr | Congenital Oligodendroglioma: Clinicopathologic and Molecular Assessment with Review of the Literature |
| title_full_unstemmed | Congenital Oligodendroglioma: Clinicopathologic and Molecular Assessment with Review of the Literature |
| title_short | Congenital Oligodendroglioma: Clinicopathologic and Molecular Assessment with Review of the Literature |
| title_sort | congenital oligodendroglioma clinicopathologic and molecular assessment with review of the literature |
| url | http://dx.doi.org/10.1155/2015/370234 |
| work_keys_str_mv | AT hoperichard congenitaloligodendrogliomaclinicopathologicandmolecularassessmentwithreviewoftheliterature AT kimberlystognerunderwood congenitaloligodendrogliomaclinicopathologicandmolecularassessmentwithreviewoftheliterature AT christinefuller congenitaloligodendrogliomaclinicopathologicandmolecularassessmentwithreviewoftheliterature |