Mesenchymal Stem Cells in Sepsis and Associated Organ Dysfunction: A Promising Future or Blind Alley?
Sepsis, newly defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection, is the most common cause of death in ICUs and one of the principal causes of death worldwide. Although substantial progress has been made in the understanding of fundamental mechanisms...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/7304121 |
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| _version_ | 1832565153374142464 |
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| author | Jan Horák Lukáš Nalos Vendula Martínková Jan Beneš Milan Štengl Martin Matějovič |
| author_facet | Jan Horák Lukáš Nalos Vendula Martínková Jan Beneš Milan Štengl Martin Matějovič |
| author_sort | Jan Horák |
| collection | DOAJ |
| description | Sepsis, newly defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection, is the most common cause of death in ICUs and one of the principal causes of death worldwide. Although substantial progress has been made in the understanding of fundamental mechanisms of sepsis, translation of these advances into clinically effective therapies has been disappointing. Given the extreme complexity of sepsis pathogenesis, the paradigm “one disease, one drug” is obviously flawed and combinations of multiple targets that involve early immunomodulation and cellular protection are needed. In this context, the immune-reprogramming properties of cell-based therapy using mesenchymal stem cells (MSC) represent an emerging therapeutic strategy in sepsis and associated organ dysfunction. This article provides an update of the current knowledge regarding MSC in preclinical models of sepsis and sepsis-induced acute kidney injury. Recommendations for further translational research in this field are discussed. |
| format | Article |
| id | doaj-art-3109297a5ca74d54b6c1006f923a1ab9 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-3109297a5ca74d54b6c1006f923a1ab92025-02-03T01:09:05ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/73041217304121Mesenchymal Stem Cells in Sepsis and Associated Organ Dysfunction: A Promising Future or Blind Alley?Jan Horák0Lukáš Nalos1Vendula Martínková2Jan Beneš3Milan Štengl4Martin Matějovič51st Medical Department, Faculty of Medicine in Pilsen, Charles University, Prague, Czech RepublicExperimental Intensive Care Unit, Biomedical Centre, Faculty of Medicine in Plzen, Charles University, Alej Svobody 1655/76, Plzen, Czech RepublicExperimental Intensive Care Unit, Biomedical Centre, Faculty of Medicine in Plzen, Charles University, Alej Svobody 1655/76, Plzen, Czech RepublicExperimental Intensive Care Unit, Biomedical Centre, Faculty of Medicine in Plzen, Charles University, Alej Svobody 1655/76, Plzen, Czech RepublicExperimental Intensive Care Unit, Biomedical Centre, Faculty of Medicine in Plzen, Charles University, Alej Svobody 1655/76, Plzen, Czech Republic1st Medical Department, Faculty of Medicine in Pilsen, Charles University, Prague, Czech RepublicSepsis, newly defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection, is the most common cause of death in ICUs and one of the principal causes of death worldwide. Although substantial progress has been made in the understanding of fundamental mechanisms of sepsis, translation of these advances into clinically effective therapies has been disappointing. Given the extreme complexity of sepsis pathogenesis, the paradigm “one disease, one drug” is obviously flawed and combinations of multiple targets that involve early immunomodulation and cellular protection are needed. In this context, the immune-reprogramming properties of cell-based therapy using mesenchymal stem cells (MSC) represent an emerging therapeutic strategy in sepsis and associated organ dysfunction. This article provides an update of the current knowledge regarding MSC in preclinical models of sepsis and sepsis-induced acute kidney injury. Recommendations for further translational research in this field are discussed.http://dx.doi.org/10.1155/2017/7304121 |
| spellingShingle | Jan Horák Lukáš Nalos Vendula Martínková Jan Beneš Milan Štengl Martin Matějovič Mesenchymal Stem Cells in Sepsis and Associated Organ Dysfunction: A Promising Future or Blind Alley? Stem Cells International |
| title | Mesenchymal Stem Cells in Sepsis and Associated Organ Dysfunction: A Promising Future or Blind Alley? |
| title_full | Mesenchymal Stem Cells in Sepsis and Associated Organ Dysfunction: A Promising Future or Blind Alley? |
| title_fullStr | Mesenchymal Stem Cells in Sepsis and Associated Organ Dysfunction: A Promising Future or Blind Alley? |
| title_full_unstemmed | Mesenchymal Stem Cells in Sepsis and Associated Organ Dysfunction: A Promising Future or Blind Alley? |
| title_short | Mesenchymal Stem Cells in Sepsis and Associated Organ Dysfunction: A Promising Future or Blind Alley? |
| title_sort | mesenchymal stem cells in sepsis and associated organ dysfunction a promising future or blind alley |
| url | http://dx.doi.org/10.1155/2017/7304121 |
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