The Effects of Renal Nerve Denervation on Blood Pressure and Target Organs in Different Hypertensive Rat Models
Background. Hypertension contributes to the progression of cardiac remodeling and renal damage. In turn, renal sympathetic hyperactivation showed elevated sympathetic nervous system activity and led to blood pressure increase in certain patients. The purpose of this study was to observe the effect o...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2021/8615253 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832555235856351232 |
|---|---|
| author | Demin Liu Jing Wang Haijuan Hu Guoqiang Gu Rui Ding Ruiqin Xie Wei Cui |
| author_facet | Demin Liu Jing Wang Haijuan Hu Guoqiang Gu Rui Ding Ruiqin Xie Wei Cui |
| author_sort | Demin Liu |
| collection | DOAJ |
| description | Background. Hypertension contributes to the progression of cardiac remodeling and renal damage. In turn, renal sympathetic hyperactivation showed elevated sympathetic nervous system activity and led to blood pressure increase in certain patients. The purpose of this study was to observe the effect of renal nerve denervation on blood pressure and target organ changes in two hypertensive rat models. Methods. Hypertensive rats were randomly divided into a renal denervation (RDN) group and sham operation group. Wistar–Kyoto (WKY) rats of the same age were set as the baseline control group. In the secondary hypertension model, SD rats were randomly divided into five groups. Blood pressure and bodyweight were measured every week until they were euthanized. Results. The two rat models underwent RDN at key timepoints. At these timepoints, the hearts and kidneys were collected for norepinephrine and angiotensin II measurements and histological analysis. Conclusion. RDN performed before development of hypertension showed a significant antihypertensive effect on the secondary hypertension model. |
| format | Article |
| id | doaj-art-30fd2226bf13491b8deb0bedca45f2c6 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-30fd2226bf13491b8deb0bedca45f2c62025-02-03T05:49:16ZengWileyInternational Journal of Hypertension2090-03842090-03922021-01-01202110.1155/2021/86152538615253The Effects of Renal Nerve Denervation on Blood Pressure and Target Organs in Different Hypertensive Rat ModelsDemin Liu0Jing Wang1Haijuan Hu2Guoqiang Gu3Rui Ding4Ruiqin Xie5Wei Cui6Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, ChinaBackground. Hypertension contributes to the progression of cardiac remodeling and renal damage. In turn, renal sympathetic hyperactivation showed elevated sympathetic nervous system activity and led to blood pressure increase in certain patients. The purpose of this study was to observe the effect of renal nerve denervation on blood pressure and target organ changes in two hypertensive rat models. Methods. Hypertensive rats were randomly divided into a renal denervation (RDN) group and sham operation group. Wistar–Kyoto (WKY) rats of the same age were set as the baseline control group. In the secondary hypertension model, SD rats were randomly divided into five groups. Blood pressure and bodyweight were measured every week until they were euthanized. Results. The two rat models underwent RDN at key timepoints. At these timepoints, the hearts and kidneys were collected for norepinephrine and angiotensin II measurements and histological analysis. Conclusion. RDN performed before development of hypertension showed a significant antihypertensive effect on the secondary hypertension model.http://dx.doi.org/10.1155/2021/8615253 |
| spellingShingle | Demin Liu Jing Wang Haijuan Hu Guoqiang Gu Rui Ding Ruiqin Xie Wei Cui The Effects of Renal Nerve Denervation on Blood Pressure and Target Organs in Different Hypertensive Rat Models International Journal of Hypertension |
| title | The Effects of Renal Nerve Denervation on Blood Pressure and Target Organs in Different Hypertensive Rat Models |
| title_full | The Effects of Renal Nerve Denervation on Blood Pressure and Target Organs in Different Hypertensive Rat Models |
| title_fullStr | The Effects of Renal Nerve Denervation on Blood Pressure and Target Organs in Different Hypertensive Rat Models |
| title_full_unstemmed | The Effects of Renal Nerve Denervation on Blood Pressure and Target Organs in Different Hypertensive Rat Models |
| title_short | The Effects of Renal Nerve Denervation on Blood Pressure and Target Organs in Different Hypertensive Rat Models |
| title_sort | effects of renal nerve denervation on blood pressure and target organs in different hypertensive rat models |
| url | http://dx.doi.org/10.1155/2021/8615253 |
| work_keys_str_mv | AT deminliu theeffectsofrenalnervedenervationonbloodpressureandtargetorgansindifferenthypertensiveratmodels AT jingwang theeffectsofrenalnervedenervationonbloodpressureandtargetorgansindifferenthypertensiveratmodels AT haijuanhu theeffectsofrenalnervedenervationonbloodpressureandtargetorgansindifferenthypertensiveratmodels AT guoqianggu theeffectsofrenalnervedenervationonbloodpressureandtargetorgansindifferenthypertensiveratmodels AT ruiding theeffectsofrenalnervedenervationonbloodpressureandtargetorgansindifferenthypertensiveratmodels AT ruiqinxie theeffectsofrenalnervedenervationonbloodpressureandtargetorgansindifferenthypertensiveratmodels AT weicui theeffectsofrenalnervedenervationonbloodpressureandtargetorgansindifferenthypertensiveratmodels AT deminliu effectsofrenalnervedenervationonbloodpressureandtargetorgansindifferenthypertensiveratmodels AT jingwang effectsofrenalnervedenervationonbloodpressureandtargetorgansindifferenthypertensiveratmodels AT haijuanhu effectsofrenalnervedenervationonbloodpressureandtargetorgansindifferenthypertensiveratmodels AT guoqianggu effectsofrenalnervedenervationonbloodpressureandtargetorgansindifferenthypertensiveratmodels AT ruiding effectsofrenalnervedenervationonbloodpressureandtargetorgansindifferenthypertensiveratmodels AT ruiqinxie effectsofrenalnervedenervationonbloodpressureandtargetorgansindifferenthypertensiveratmodels AT weicui effectsofrenalnervedenervationonbloodpressureandtargetorgansindifferenthypertensiveratmodels |