Insulin in Central Nervous System: More than Just a Peripheral Hormone
Insulin signaling in central nervous system (CNS) has emerged as a novel field of research since decreased brain insulin levels and/or signaling were associated to impaired learning, memory, and age-related neurodegenerative diseases. Thus, besides its well-known role in longevity, insulin may const...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.1155/2012/384017 |
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| author | Ana I. Duarte Paula I. Moreira Catarina R. Oliveira |
| author_facet | Ana I. Duarte Paula I. Moreira Catarina R. Oliveira |
| author_sort | Ana I. Duarte |
| collection | DOAJ |
| description | Insulin signaling in central nervous system (CNS) has emerged as a novel field of research since decreased brain insulin levels and/or signaling were associated to impaired learning, memory, and age-related neurodegenerative diseases. Thus, besides its well-known role in longevity, insulin may constitute a promising therapy against diabetes- and age-related neurodegenerative disorders. More interestingly, insulin has been also faced as the potential missing link between diabetes and aging in CNS, with Alzheimer's disease (AD) considered as the “brain-type diabetes.” In fact, brain insulin has been shown to regulate both peripheral and central glucose metabolism, neurotransmission, learning, and memory and to be neuroprotective. And a future challenge will be to unravel the complex interactions between aging and diabetes, which, we believe, will allow the development of efficient preventive and therapeutic strategies to overcome age-related diseases and to prolong human “healthy” longevity. Herewith, we aim to integrate the metabolic, neuromodulatory, and neuroprotective roles of insulin in two age-related pathologies: diabetes and AD, both in terms of intracellular signaling and potential therapeutic approach. |
| format | Article |
| id | doaj-art-30fbdccb2123406ba81ac0cbb49b9c96 |
| institution | Kabale University |
| issn | 2090-2204 2090-2212 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-30fbdccb2123406ba81ac0cbb49b9c962025-02-03T05:50:26ZengWileyJournal of Aging Research2090-22042090-22122012-01-01201210.1155/2012/384017384017Insulin in Central Nervous System: More than Just a Peripheral HormoneAna I. Duarte0Paula I. Moreira1Catarina R. Oliveira2CNC, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, PortugalCNC, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, PortugalCNC, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, PortugalInsulin signaling in central nervous system (CNS) has emerged as a novel field of research since decreased brain insulin levels and/or signaling were associated to impaired learning, memory, and age-related neurodegenerative diseases. Thus, besides its well-known role in longevity, insulin may constitute a promising therapy against diabetes- and age-related neurodegenerative disorders. More interestingly, insulin has been also faced as the potential missing link between diabetes and aging in CNS, with Alzheimer's disease (AD) considered as the “brain-type diabetes.” In fact, brain insulin has been shown to regulate both peripheral and central glucose metabolism, neurotransmission, learning, and memory and to be neuroprotective. And a future challenge will be to unravel the complex interactions between aging and diabetes, which, we believe, will allow the development of efficient preventive and therapeutic strategies to overcome age-related diseases and to prolong human “healthy” longevity. Herewith, we aim to integrate the metabolic, neuromodulatory, and neuroprotective roles of insulin in two age-related pathologies: diabetes and AD, both in terms of intracellular signaling and potential therapeutic approach.http://dx.doi.org/10.1155/2012/384017 |
| spellingShingle | Ana I. Duarte Paula I. Moreira Catarina R. Oliveira Insulin in Central Nervous System: More than Just a Peripheral Hormone Journal of Aging Research |
| title | Insulin in Central Nervous System: More than Just a Peripheral Hormone |
| title_full | Insulin in Central Nervous System: More than Just a Peripheral Hormone |
| title_fullStr | Insulin in Central Nervous System: More than Just a Peripheral Hormone |
| title_full_unstemmed | Insulin in Central Nervous System: More than Just a Peripheral Hormone |
| title_short | Insulin in Central Nervous System: More than Just a Peripheral Hormone |
| title_sort | insulin in central nervous system more than just a peripheral hormone |
| url | http://dx.doi.org/10.1155/2012/384017 |
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