Natural Compounds as Regulators of NLRP3 Inflammasome-Mediated IL-1β Production
IL-1β is one of the main proinflammatory cytokines that regulates a broad range of immune responses and also participates in several physiological processes. The canonical production of IL-1β requires multiprotein complexes called inflammasomes. One of the most intensively studied inflammasome compl...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/5460302 |
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| author | József Tőzsér Szilvia Benkő |
| author_facet | József Tőzsér Szilvia Benkő |
| author_sort | József Tőzsér |
| collection | DOAJ |
| description | IL-1β is one of the main proinflammatory cytokines that regulates a broad range of immune responses and also participates in several physiological processes. The canonical production of IL-1β requires multiprotein complexes called inflammasomes. One of the most intensively studied inflammasome complexes is the NLRP3 inflammasome. Its activation requires two signals: one signal “primes” the cells and induces the expression of NLRP3 and pro-IL-1β, while the other signal leads to the assembly and activation of the complex. Several stimuli were reported to function as the second signal including reactive oxygen species, lysosomal rupture, or cytosolic ion perturbation. Despite very intensive studies, the precise function and regulation of the NLRP3 inflammasome are still not clear. However, many chronic inflammatory diseases are related to the overproduction of IL-1β that is mediated via the NLRP3 inflammasome. In this review, we aimed to provide an overview of studies that demonstrated the effect of plant-derived natural compounds on NLRP3 inflammasome-mediated IL-1β production. Although many of these studies lack the mechanistic explanation of their action, these compounds may be considered as complementary supplements in the treatment of chronic inflammatory diseases, consumed as preventive agents, and may also be considered as molecular tools to study NLRP3 function. |
| format | Article |
| id | doaj-art-30ed59b353404b9cbff305a6fee161a9 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-30ed59b353404b9cbff305a6fee161a92025-02-03T06:13:47ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/54603025460302Natural Compounds as Regulators of NLRP3 Inflammasome-Mediated IL-1β ProductionJózsef Tőzsér0Szilvia Benkő1Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, HungaryDepartment of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, HungaryIL-1β is one of the main proinflammatory cytokines that regulates a broad range of immune responses and also participates in several physiological processes. The canonical production of IL-1β requires multiprotein complexes called inflammasomes. One of the most intensively studied inflammasome complexes is the NLRP3 inflammasome. Its activation requires two signals: one signal “primes” the cells and induces the expression of NLRP3 and pro-IL-1β, while the other signal leads to the assembly and activation of the complex. Several stimuli were reported to function as the second signal including reactive oxygen species, lysosomal rupture, or cytosolic ion perturbation. Despite very intensive studies, the precise function and regulation of the NLRP3 inflammasome are still not clear. However, many chronic inflammatory diseases are related to the overproduction of IL-1β that is mediated via the NLRP3 inflammasome. In this review, we aimed to provide an overview of studies that demonstrated the effect of plant-derived natural compounds on NLRP3 inflammasome-mediated IL-1β production. Although many of these studies lack the mechanistic explanation of their action, these compounds may be considered as complementary supplements in the treatment of chronic inflammatory diseases, consumed as preventive agents, and may also be considered as molecular tools to study NLRP3 function.http://dx.doi.org/10.1155/2016/5460302 |
| spellingShingle | József Tőzsér Szilvia Benkő Natural Compounds as Regulators of NLRP3 Inflammasome-Mediated IL-1β Production Mediators of Inflammation |
| title | Natural Compounds as Regulators of NLRP3 Inflammasome-Mediated IL-1β Production |
| title_full | Natural Compounds as Regulators of NLRP3 Inflammasome-Mediated IL-1β Production |
| title_fullStr | Natural Compounds as Regulators of NLRP3 Inflammasome-Mediated IL-1β Production |
| title_full_unstemmed | Natural Compounds as Regulators of NLRP3 Inflammasome-Mediated IL-1β Production |
| title_short | Natural Compounds as Regulators of NLRP3 Inflammasome-Mediated IL-1β Production |
| title_sort | natural compounds as regulators of nlrp3 inflammasome mediated il 1β production |
| url | http://dx.doi.org/10.1155/2016/5460302 |
| work_keys_str_mv | AT jozseftozser naturalcompoundsasregulatorsofnlrp3inflammasomemediatedil1bproduction AT szilviabenko naturalcompoundsasregulatorsofnlrp3inflammasomemediatedil1bproduction |