Myopathy with Concurrent Tadalafil and Simvastatin
A 48-year-old man, using statin, was admitted to hospital with progressive myalgia after consumption of tadalafil and simvastatin. Muscle pain and penile erection disappeared seven days after interruption of therapy. This case demonstrates the interaction of tadalafil with simvastatin resulting in m...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
|
| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2009/378287 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564941411844096 |
|---|---|
| author | Maria Pia Gargante Marco Vacante Cristina Russo Mariano Malaguarnera |
| author_facet | Maria Pia Gargante Marco Vacante Cristina Russo Mariano Malaguarnera |
| author_sort | Maria Pia Gargante |
| collection | DOAJ |
| description | A 48-year-old man, using statin, was admitted to hospital with progressive myalgia after consumption of tadalafil and simvastatin. Muscle pain and penile erection disappeared seven days after interruption of therapy. This case demonstrates the interaction of tadalafil with simvastatin resulting in myopathy. Muscle damage could be attributed to the common metabolic way of these two drugs which is cytochrome P450 isoenzyme system. |
| format | Article |
| id | doaj-art-30e1091bf9b94df89800f79cbd708a7c |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-30e1091bf9b94df89800f79cbd708a7c2025-02-03T01:09:49ZengWileyCase Reports in Medicine1687-96271687-96352009-01-01200910.1155/2009/378287378287Myopathy with Concurrent Tadalafil and SimvastatinMaria Pia Gargante0Marco Vacante1Cristina Russo2Mariano Malaguarnera3Department of Senescence, Urological and Neurological Sciences Ospedale Cannizzaro, Viale Messina, 95125 Catania, ItalyDepartment of Senescence, Urological and Neurological Sciences Ospedale Cannizzaro, Viale Messina, 95125 Catania, ItalyDepartment of Senescence, Urological and Neurological Sciences Ospedale Cannizzaro, Viale Messina, 95125 Catania, ItalyDepartment of Senescence, Urological and Neurological Sciences Ospedale Cannizzaro, Viale Messina, 95125 Catania, ItalyA 48-year-old man, using statin, was admitted to hospital with progressive myalgia after consumption of tadalafil and simvastatin. Muscle pain and penile erection disappeared seven days after interruption of therapy. This case demonstrates the interaction of tadalafil with simvastatin resulting in myopathy. Muscle damage could be attributed to the common metabolic way of these two drugs which is cytochrome P450 isoenzyme system.http://dx.doi.org/10.1155/2009/378287 |
| spellingShingle | Maria Pia Gargante Marco Vacante Cristina Russo Mariano Malaguarnera Myopathy with Concurrent Tadalafil and Simvastatin Case Reports in Medicine |
| title | Myopathy with Concurrent Tadalafil and Simvastatin |
| title_full | Myopathy with Concurrent Tadalafil and Simvastatin |
| title_fullStr | Myopathy with Concurrent Tadalafil and Simvastatin |
| title_full_unstemmed | Myopathy with Concurrent Tadalafil and Simvastatin |
| title_short | Myopathy with Concurrent Tadalafil and Simvastatin |
| title_sort | myopathy with concurrent tadalafil and simvastatin |
| url | http://dx.doi.org/10.1155/2009/378287 |
| work_keys_str_mv | AT mariapiagargante myopathywithconcurrenttadalafilandsimvastatin AT marcovacante myopathywithconcurrenttadalafilandsimvastatin AT cristinarusso myopathywithconcurrenttadalafilandsimvastatin AT marianomalaguarnera myopathywithconcurrenttadalafilandsimvastatin |