Anti-colon cancer activity of water-soluble polysaccharides extracted from Gloeostereum incarnatum via Wnt/β-catenin signaling pathway
The incidence rate of colon cancer ranks the third among malignant tumors worldwide. Gloeostereum incarnatum (GI), a fungus with homology of medicine and food, has multiple pharmacological activities. It was investigated in this study that the anti-colon cancer effect of polysaccharides purified fro...
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| Language: | English |
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Tsinghua University Press
2021-07-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453021000550 |
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| author | Jiawei He Anhui Yang Xuyu Zhao Yang Liu Shuyan Liu Di Wang |
| author_facet | Jiawei He Anhui Yang Xuyu Zhao Yang Liu Shuyan Liu Di Wang |
| author_sort | Jiawei He |
| collection | DOAJ |
| description | The incidence rate of colon cancer ranks the third among malignant tumors worldwide. Gloeostereum incarnatum (GI), a fungus with homology of medicine and food, has multiple pharmacological activities. It was investigated in this study that the anti-colon cancer effect of polysaccharides purified from GI (GIPS) in ApcMinC/Gpt mice (an in situ colon cancer mouse model). Eight-week administration with GIPS at doses of 30 or 90 mg/kg strongly inhibited tumor growth including the reduction on numbers and the suppression of the size without influencing the animals’ body weight and organ functions. According to the proteomics performing by antibody array, among 308 detected cytokines, GIPS significantly regulated 89 of them. Compared with vehicle-treated mice, GIPS effectively reduced the levels of interleukin (IL)-1β, IL-4, IL-6, IL-17, IL-22, tumor necrosis factor (TNF)-α, matrix metalloproteinase (MMP)-2, and enhanced the levels of IL-15 and IL-18 in serum and/or colon tissues, which suggested its anti-inflammation of GIPS. GIPS suppressed nuclear aggregation of β-catenin, affected the expression of WNT1 and related proteins, thereby regulated the activation of the Wnt signaling. Altogether, GIPS can inhibit the growth of colon cancer, at least partially, via inhibiting the Wnt/β-catenin signaling pathway. |
| format | Article |
| id | doaj-art-30db5aed19584469b3625d783aeafeaa |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2021-07-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-30db5aed19584469b3625d783aeafeaa2025-02-03T10:34:57ZengTsinghua University PressFood Science and Human Wellness2213-45302021-07-01104460470Anti-colon cancer activity of water-soluble polysaccharides extracted from Gloeostereum incarnatum via Wnt/β-catenin signaling pathwayJiawei He0Anhui Yang1Xuyu Zhao2Yang Liu3Shuyan Liu4Di Wang5Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, China; School of Life Sciences, Jilin University, Changchun 130012, ChinaSchool of Life Sciences, Jilin University, Changchun 130012, ChinaEngineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, ChinaEngineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, ChinaEngineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, China; Corresponding author.School of Life Sciences, Jilin University, Changchun 130012, China; Corresponding author.The incidence rate of colon cancer ranks the third among malignant tumors worldwide. Gloeostereum incarnatum (GI), a fungus with homology of medicine and food, has multiple pharmacological activities. It was investigated in this study that the anti-colon cancer effect of polysaccharides purified from GI (GIPS) in ApcMinC/Gpt mice (an in situ colon cancer mouse model). Eight-week administration with GIPS at doses of 30 or 90 mg/kg strongly inhibited tumor growth including the reduction on numbers and the suppression of the size without influencing the animals’ body weight and organ functions. According to the proteomics performing by antibody array, among 308 detected cytokines, GIPS significantly regulated 89 of them. Compared with vehicle-treated mice, GIPS effectively reduced the levels of interleukin (IL)-1β, IL-4, IL-6, IL-17, IL-22, tumor necrosis factor (TNF)-α, matrix metalloproteinase (MMP)-2, and enhanced the levels of IL-15 and IL-18 in serum and/or colon tissues, which suggested its anti-inflammation of GIPS. GIPS suppressed nuclear aggregation of β-catenin, affected the expression of WNT1 and related proteins, thereby regulated the activation of the Wnt signaling. Altogether, GIPS can inhibit the growth of colon cancer, at least partially, via inhibiting the Wnt/β-catenin signaling pathway.http://www.sciencedirect.com/science/article/pii/S2213453021000550Gloeostereum incarnatum, Water-soluble polysaccharides, Colon cancer, Wnt/β-catenin |
| spellingShingle | Jiawei He Anhui Yang Xuyu Zhao Yang Liu Shuyan Liu Di Wang Anti-colon cancer activity of water-soluble polysaccharides extracted from Gloeostereum incarnatum via Wnt/β-catenin signaling pathway Food Science and Human Wellness Gloeostereum incarnatum, Water-soluble polysaccharides, Colon cancer, Wnt/β-catenin |
| title | Anti-colon cancer activity of water-soluble polysaccharides extracted from Gloeostereum incarnatum via Wnt/β-catenin signaling pathway |
| title_full | Anti-colon cancer activity of water-soluble polysaccharides extracted from Gloeostereum incarnatum via Wnt/β-catenin signaling pathway |
| title_fullStr | Anti-colon cancer activity of water-soluble polysaccharides extracted from Gloeostereum incarnatum via Wnt/β-catenin signaling pathway |
| title_full_unstemmed | Anti-colon cancer activity of water-soluble polysaccharides extracted from Gloeostereum incarnatum via Wnt/β-catenin signaling pathway |
| title_short | Anti-colon cancer activity of water-soluble polysaccharides extracted from Gloeostereum incarnatum via Wnt/β-catenin signaling pathway |
| title_sort | anti colon cancer activity of water soluble polysaccharides extracted from gloeostereum incarnatum via wnt β catenin signaling pathway |
| topic | Gloeostereum incarnatum, Water-soluble polysaccharides, Colon cancer, Wnt/β-catenin |
| url | http://www.sciencedirect.com/science/article/pii/S2213453021000550 |
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