Association Of Functional Dyspepsia With Depression; Gut-Brain Axis And Mental Health
Objective: Current study aimed to determine the frequency and associations of depression in patients with & without Functional dyspepsia. Method: This case control study was conducted at Dept. of Medicine, RIHS, Islamabad (Jan-June 2023) after ethical approval. Cases & controls (150 each)...
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Rawalpindi Medical University
2024-03-01
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| Series: | Journal of Rawalpindi Medical College |
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| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/2427 |
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| author | Nadia Shams Fareya Usmani Hina Andaleeb Furquana Niaz Lubna Meraj Nargis Munir |
| author_facet | Nadia Shams Fareya Usmani Hina Andaleeb Furquana Niaz Lubna Meraj Nargis Munir |
| author_sort | Nadia Shams |
| collection | DOAJ |
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Objective: Current study aimed to determine the frequency and associations of depression in patients with & without Functional dyspepsia.
Method: This case control study was conducted at Dept. of Medicine, RIHS, Islamabad (Jan-June 2023) after ethical approval. Cases & controls (150 each) were selected from outdoor clinics according to inclusion/exclusion criteria & informed consent was obtained. The previous medical record (including findings of upper GI Endoscopy) reviewed. Selected cases and controls were asked questions from DSM-IV Criteria of Depression. Data analyzed by SPSS with significant p<0.05.
Results: There were 72(48 %) males & 78(52%) females in each group. Mean age was 43.7+13.79 years (FD patients) vs. 46.24+15.27 years (controls). Mean BMI was 24.84+4.18 (FD patients) vs. 25.38+4.52 (controls). There was no significant difference in gender, marital status & background of both groups. There was significantly more depression in FD patients Vs. controls (p<0.05). Among FD patients 57(38%) had major depression, 41(27.33%) minor depression & 52(34.66%) were not depressed. Among controls 41(27.33%) had major depression, 30(20%) minor depression & 79(52.66%) not depressed. Among FD patients, depression wasn’t associated with age. Controls above 40 years had significantly higher major depression (p<0.001). Female gender & unemployment was significantly associated with depression in both the groups (p<0.05). 49.3% of FD patients were employed vs. 67.3% of controls.
Conclusion: The adjustment for gender, age, marital status, BMI, background & monthly income confirmed the association between Functional dyspepsia & depression. Female gender, unemployment and low educational status being possible risk factors for depression among FD patients. As compared to normal healthy people, FD patients are likely to have depression at younger age.
Key words: Functional dyspepsia. Depression. DSM-IV Criteria
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| format | Article |
| id | doaj-art-30cd4377f2ef44e58a6ce18cc4f44b38 |
| institution | Kabale University |
| issn | 1683-3562 1683-3570 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Rawalpindi Medical University |
| record_format | Article |
| series | Journal of Rawalpindi Medical College |
| spelling | doaj-art-30cd4377f2ef44e58a6ce18cc4f44b382025-02-06T08:38:15ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702024-03-0128110.37939/jrmc.v28i1.2427Association Of Functional Dyspepsia With Depression; Gut-Brain Axis And Mental Health Nadia Shams0Fareya Usmani1Hina Andaleeb2Furquana Niaz3Lubna Meraj4Nargis Munir5RIHS IslamabadUnited Medical and Dental CollegeRIHS IslamabadIbn e Sina Hospital and Ashfaq Memorial HospitalRMURIHS Islamabad Objective: Current study aimed to determine the frequency and associations of depression in patients with & without Functional dyspepsia. Method: This case control study was conducted at Dept. of Medicine, RIHS, Islamabad (Jan-June 2023) after ethical approval. Cases & controls (150 each) were selected from outdoor clinics according to inclusion/exclusion criteria & informed consent was obtained. The previous medical record (including findings of upper GI Endoscopy) reviewed. Selected cases and controls were asked questions from DSM-IV Criteria of Depression. Data analyzed by SPSS with significant p<0.05. Results: There were 72(48 %) males & 78(52%) females in each group. Mean age was 43.7+13.79 years (FD patients) vs. 46.24+15.27 years (controls). Mean BMI was 24.84+4.18 (FD patients) vs. 25.38+4.52 (controls). There was no significant difference in gender, marital status & background of both groups. There was significantly more depression in FD patients Vs. controls (p<0.05). Among FD patients 57(38%) had major depression, 41(27.33%) minor depression & 52(34.66%) were not depressed. Among controls 41(27.33%) had major depression, 30(20%) minor depression & 79(52.66%) not depressed. Among FD patients, depression wasn’t associated with age. Controls above 40 years had significantly higher major depression (p<0.001). Female gender & unemployment was significantly associated with depression in both the groups (p<0.05). 49.3% of FD patients were employed vs. 67.3% of controls. Conclusion: The adjustment for gender, age, marital status, BMI, background & monthly income confirmed the association between Functional dyspepsia & depression. Female gender, unemployment and low educational status being possible risk factors for depression among FD patients. As compared to normal healthy people, FD patients are likely to have depression at younger age. Key words: Functional dyspepsia. Depression. DSM-IV Criteria https://www.journalrmc.com/index.php/JRMC/article/view/2427Functional dyspepsia. Depression. DSM-IV Criteria. |
| spellingShingle | Nadia Shams Fareya Usmani Hina Andaleeb Furquana Niaz Lubna Meraj Nargis Munir Association Of Functional Dyspepsia With Depression; Gut-Brain Axis And Mental Health Journal of Rawalpindi Medical College Functional dyspepsia. Depression. DSM-IV Criteria. |
| title | Association Of Functional Dyspepsia With Depression; Gut-Brain Axis And Mental Health |
| title_full | Association Of Functional Dyspepsia With Depression; Gut-Brain Axis And Mental Health |
| title_fullStr | Association Of Functional Dyspepsia With Depression; Gut-Brain Axis And Mental Health |
| title_full_unstemmed | Association Of Functional Dyspepsia With Depression; Gut-Brain Axis And Mental Health |
| title_short | Association Of Functional Dyspepsia With Depression; Gut-Brain Axis And Mental Health |
| title_sort | association of functional dyspepsia with depression gut brain axis and mental health |
| topic | Functional dyspepsia. Depression. DSM-IV Criteria. |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/2427 |
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