Research Progress of SGLT2 Inhibitors in Cancer Treatment
Xiaoyong Miao,1,* Jianing Zhang,2,* Weiyan Huang,2,* Yifei Wang,1 Aixia Jin,1 Jianping Cao,1 Zhenzhen Zhao3 1Department of Anesthesiology, Naval Medical Center, Naval Medical University, Shanghai, People’s Republic of China; 2Student Brigade, Changhai Hospital, Naval Medical...
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Dove Medical Press
2025-01-01
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| author | Miao X Zhang J Huang W Wang Y Jin A Cao J Zhao Z |
| author_facet | Miao X Zhang J Huang W Wang Y Jin A Cao J Zhao Z |
| author_sort | Miao X |
| collection | DOAJ |
| description | Xiaoyong Miao,1,* Jianing Zhang,2,* Weiyan Huang,2,* Yifei Wang,1 Aixia Jin,1 Jianping Cao,1 Zhenzhen Zhao3 1Department of Anesthesiology, Naval Medical Center, Naval Medical University, Shanghai, People’s Republic of China; 2Student Brigade, Changhai Hospital, Naval Medical University, Shanghai, People’s Republic of China; 3Department of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhenzhen Zhao, Department of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, 200433, People’s Republic of China, Email zpluto@163.com Jianping Cao, Department of Anesthesiology, Naval Medical Center, Naval Medical University, Shanghai, 200050, People’s Republic of China, Email cjpcl221019@sina.comAbstract: Sodium glucose co-transporter 2 (SGLT2) inhibitors represent a novel class of hypoglycemic drugs that have emerged in recent years. These inhibitors function primarily by blocking the reabsorption of glucose in the kidneys, specifically targeting the SGLT2 proteins in the proximal convoluted tubules. This inhibition results in the reduction of blood glucose levels through increased glucose excretion in the urine. Recent studies have identified SGLT2 expression in various cancer types, suggesting that SGLT2 inhibition can potentially suppress tumor growth. This article provides a comprehensive review of the role of SGLT2 in tumorigenesis and tumor progression, and explores the underlying mechanisms and potential therapeutic applications of SGLT2 inhibitors as anticancer agents.Keywords: SGLT2 inhibitors, SGLT2, cancer, mechanism |
| format | Article |
| id | doaj-art-30b46c20c59e41a5801bc27c9cdbfc21 |
| institution | Kabale University |
| issn | 1177-8881 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj-art-30b46c20c59e41a5801bc27c9cdbfc212025-01-23T18:50:32ZengDove Medical PressDrug Design, Development and Therapy1177-88812025-01-01Volume 1950551499521Research Progress of SGLT2 Inhibitors in Cancer TreatmentMiao XZhang JHuang WWang YJin ACao JZhao ZXiaoyong Miao,1,* Jianing Zhang,2,* Weiyan Huang,2,* Yifei Wang,1 Aixia Jin,1 Jianping Cao,1 Zhenzhen Zhao3 1Department of Anesthesiology, Naval Medical Center, Naval Medical University, Shanghai, People’s Republic of China; 2Student Brigade, Changhai Hospital, Naval Medical University, Shanghai, People’s Republic of China; 3Department of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhenzhen Zhao, Department of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, 200433, People’s Republic of China, Email zpluto@163.com Jianping Cao, Department of Anesthesiology, Naval Medical Center, Naval Medical University, Shanghai, 200050, People’s Republic of China, Email cjpcl221019@sina.comAbstract: Sodium glucose co-transporter 2 (SGLT2) inhibitors represent a novel class of hypoglycemic drugs that have emerged in recent years. These inhibitors function primarily by blocking the reabsorption of glucose in the kidneys, specifically targeting the SGLT2 proteins in the proximal convoluted tubules. This inhibition results in the reduction of blood glucose levels through increased glucose excretion in the urine. Recent studies have identified SGLT2 expression in various cancer types, suggesting that SGLT2 inhibition can potentially suppress tumor growth. This article provides a comprehensive review of the role of SGLT2 in tumorigenesis and tumor progression, and explores the underlying mechanisms and potential therapeutic applications of SGLT2 inhibitors as anticancer agents.Keywords: SGLT2 inhibitors, SGLT2, cancer, mechanismhttps://www.dovepress.com/research-progress-of-sglt2-inhibitors-in-cancer-treatment-peer-reviewed-fulltext-article-DDDTsglt2 inhibitorssglt2cancermechanism |
| spellingShingle | Miao X Zhang J Huang W Wang Y Jin A Cao J Zhao Z Research Progress of SGLT2 Inhibitors in Cancer Treatment Drug Design, Development and Therapy sglt2 inhibitors sglt2 cancer mechanism |
| title | Research Progress of SGLT2 Inhibitors in Cancer Treatment |
| title_full | Research Progress of SGLT2 Inhibitors in Cancer Treatment |
| title_fullStr | Research Progress of SGLT2 Inhibitors in Cancer Treatment |
| title_full_unstemmed | Research Progress of SGLT2 Inhibitors in Cancer Treatment |
| title_short | Research Progress of SGLT2 Inhibitors in Cancer Treatment |
| title_sort | research progress of sglt2 inhibitors in cancer treatment |
| topic | sglt2 inhibitors sglt2 cancer mechanism |
| url | https://www.dovepress.com/research-progress-of-sglt2-inhibitors-in-cancer-treatment-peer-reviewed-fulltext-article-DDDT |
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