Regional Differences in the Frequency of BRCA1 and BRCA2 Variants in Northeastern Japan: A Cohort Study

Regional Differences in the Frequency of BRCA1 and BRCA2 Variants in Northeastern Japan: A Cohort Study

ABSTRACT Background Germline mutations in BRCA1/2 are known to cause hereditary tumors in the breast, ovary, and other organs. With the widespread adoption of comprehensive diagnostics, including comprehensive genomic profiling (CGP) tests for solid tumors, many patients with BRCA1/2 variants have b...

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Main Authors: Hidekazu Shirota, Akimitsu Miyake, Maako Kawamura, Shuhei Suzuki, Kensuke Saito, Jun Yasuda, Hiroyuki Shibata, Motonobu Saito, Takeshi Iwaya, Hiroshi Tada, Muneaki Shimada, Naoki Kawamorita, Masayuki Kanamori, Eisaku Miyauchi, Hidetaka Niizuma, Tomoyuki Iwasaki, Yuki Kasahara, Hiroo Imai, Ken Saijo, Keigo Komine, Masanobu Takahashi, Tetsuya Niihori, Yoko Aoki, Toru Furukawa, Gen Tamiya, Chikashi Ishioka
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Cancer Medicine
Subjects:
BRCA1
BRCA2
CGP test
geographical distribution
solid tumor
Online Access:https://doi.org/10.1002/cam4.70443
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