How to assess orodispersible film quality? A review of applied methods and their modifications
In recent years, there has been a tendency toward creating innovative, easy to use and patient-friendly drug delivery systems suitable for every consumer profile, which would ensure safety, stability and acceptability of a drug. One of the relatively novel and promising approaches is the manufacture...
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| Format: | Article |
| Language: | English |
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Sciendo
2019-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2019-0018 |
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| author | Wasilewska Katarzyna Winnicka Katarzyna |
| author_facet | Wasilewska Katarzyna Winnicka Katarzyna |
| author_sort | Wasilewska Katarzyna |
| collection | DOAJ |
| description | In recent years, there has been a tendency toward creating innovative, easy to use and patient-friendly drug delivery systems suitable for every consumer profile, which would ensure safety, stability and acceptability of a drug. One of the relatively novel and promising approaches is the manufacture of orodispersible films (ODFs), which is an upcoming area of interest in drug delivery. They are defined as polymer thin films that disintegrate in the oral cavity within seconds, without drinking water or chewing, and eliminate the risk of choking. Gaining special usefulness in therapies of children and the elderly, ODFs seem to fill the gap in the range of preparations available for these groups of patients. As no detailed monography of ODFs including testing methods and uniform requirements has been presented in any of the pharmacopoeias to date, the aim of this article is to give an overview of the applied testing methods, their modifications and innovative approaches related to ODF quality assessment. |
| format | Article |
| id | doaj-art-30b0220c89354ea0be763cb298281837 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2019-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-30b0220c89354ea0be763cb2982818372025-02-02T12:01:39ZengSciendoActa Pharmaceutica1846-95582019-06-0169215517610.2478/acph-2019-0018acph-2019-0018How to assess orodispersible film quality? A review of applied methods and their modificationsWasilewska Katarzyna0Winnicka Katarzyna1Department of Pharmaceutical Technology, Medical University of Bialystok, Bialystok 15-089, PolandDepartment of Pharmaceutical Technology, Medical University of Bialystok, Bialystok 15-089, PolandIn recent years, there has been a tendency toward creating innovative, easy to use and patient-friendly drug delivery systems suitable for every consumer profile, which would ensure safety, stability and acceptability of a drug. One of the relatively novel and promising approaches is the manufacture of orodispersible films (ODFs), which is an upcoming area of interest in drug delivery. They are defined as polymer thin films that disintegrate in the oral cavity within seconds, without drinking water or chewing, and eliminate the risk of choking. Gaining special usefulness in therapies of children and the elderly, ODFs seem to fill the gap in the range of preparations available for these groups of patients. As no detailed monography of ODFs including testing methods and uniform requirements has been presented in any of the pharmacopoeias to date, the aim of this article is to give an overview of the applied testing methods, their modifications and innovative approaches related to ODF quality assessment.https://doi.org/10.2478/acph-2019-0018orodispersible filmquality assessmentodf testing methodsmechanical propertiesdisintegration time |
| spellingShingle | Wasilewska Katarzyna Winnicka Katarzyna How to assess orodispersible film quality? A review of applied methods and their modifications Acta Pharmaceutica orodispersible film quality assessment odf testing methods mechanical properties disintegration time |
| title | How to assess orodispersible film quality? A review of applied methods and their modifications |
| title_full | How to assess orodispersible film quality? A review of applied methods and their modifications |
| title_fullStr | How to assess orodispersible film quality? A review of applied methods and their modifications |
| title_full_unstemmed | How to assess orodispersible film quality? A review of applied methods and their modifications |
| title_short | How to assess orodispersible film quality? A review of applied methods and their modifications |
| title_sort | how to assess orodispersible film quality a review of applied methods and their modifications |
| topic | orodispersible film quality assessment odf testing methods mechanical properties disintegration time |
| url | https://doi.org/10.2478/acph-2019-0018 |
| work_keys_str_mv | AT wasilewskakatarzyna howtoassessorodispersiblefilmqualityareviewofappliedmethodsandtheirmodifications AT winnickakatarzyna howtoassessorodispersiblefilmqualityareviewofappliedmethodsandtheirmodifications |