HisCoM-PAGE: software for hierarchical structural component models for pathway analysis of gene expression data

HisCoM-PAGE: software for hierarchical structural component models for pathway analysis of gene expression data

To identify pathways associated with survival phenotypes using gene expression data, we recently proposed the hierarchical structural component model for pathway analysis of gene expression data (HisCoM-PAGE) method. The HisCoM-PAGE software can consider hierarchical structural relationships between...

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Bibliographic Details
Main Authors: Lydia Mok, Taesung Park
Format: Article
Language:English
Published: BioMed Central 2019-12-01
Series:Genomics & Informatics
Subjects:
gene expression
hierarchical component model
pathway analysis
survival phenotype
Online Access:http://genominfo.org/upload/pdf/gi-2019-17-4-e45.pdf
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Summary:To identify pathways associated with survival phenotypes using gene expression data, we recently proposed the hierarchical structural component model for pathway analysis of gene expression data (HisCoM-PAGE) method. The HisCoM-PAGE software can consider hierarchical structural relationships between genes and pathways and analyze multiple pathways simultaneously. It can be applied to various types of gene expression data, such as microarray data or RNA sequencing data. We expect that the HisCoM-PAGE software will make our method more easily accessible to researchers who want to perform pathway analysis for survival times.
ISSN:2234-0742

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