Impact of donor CYP3A5 genotype on pharmacokinetics of tacrolimus in South African paediatric liver transplant patients

Impact of donor CYP3A5 genotype on pharmacokinetics of tacrolimus in South African paediatric liver transplant patients

Background. In the paediatric liver transplant programme in Johannesburg, South Africa (SA), tacrolimus is the calcineurin inhibitor of choice, comprising an essential component of the immunosuppression regimen. It is characterised by a narrow therapeutic index and wide interpatient variability...

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Bibliographic Details
Main Authors: C Wheeler, C Masimirembwa, B Mthembu, J Botha, J Scholefield, J Fabian
Format: Article
Language:English
Published: South African Medical Association 2024-04-01
Series:South African Medical Journal
Subjects:
Tacrolimus
CYP3A5
Paediatric
Liver Transplant
Living Donor
Pharmacogenetics
Online Access:https://samajournals.co.za/index.php/samj/article/view/1367
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