A Case of Isolated Primary Pleural Neurofibroma in a 39-Year-Old Woman
Primary benign neurogenic neoplasms of the pleura are exceedingly rare. Neurofibromas rarely involve the pleura. A review of the literarture reveals only a single reported case of isolated pleural neurofibroma. Herein the authors describe another case of isolated primary pleural neurofibroma. A 39-y...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Pulmonology |
| Online Access: | http://dx.doi.org/10.1155/2019/6458302 |
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| author | Kritika Krishnamurthy John Alexis Pukhraz Basra Ana Maria Medina |
| author_facet | Kritika Krishnamurthy John Alexis Pukhraz Basra Ana Maria Medina |
| author_sort | Kritika Krishnamurthy |
| collection | DOAJ |
| description | Primary benign neurogenic neoplasms of the pleura are exceedingly rare. Neurofibromas rarely involve the pleura. A review of the literarture reveals only a single reported case of isolated pleural neurofibroma. Herein the authors describe another case of isolated primary pleural neurofibroma. A 39-year-old nonsmoker woman presented to the emergency room with complaints of progressively worsening chest pain of one month duration. A computed tomography of the chest revealed a crescent shaped, pleural based mass suspicious for a neurogenic tumor such as an intercostal schwannoma. A PET-CT skull base to midthigh failed to reveal any other masses or abnormalities. A surgical excision of the mass was performed due to the patient’s intractable pain. The resected specimen consisted of an ovoid fragment of soft tissue with pale yellow, smooth and glistening cut surface. Microscopic examination revealed the tumor to be composed of spindle cells with wavy nuclei arranged haphazardly in loose collagenous and pale myxoid stroma with rare interspersed mast cells. The spindle cells were diffusely positive for S100 protein and SOX-10, and focally positive for neurofilament. In the absence of any other masses in the patient and no pertinent history, a diagnosis of primary pleural neurofibroma was made. This case emphasizes the need to consider neurofibroma in any spindle cell neoplasm of the pleura irrespective of age or singularity. |
| format | Article |
| id | doaj-art-307bb7c3a18e4a3e998b2e882ab65363 |
| institution | Kabale University |
| issn | 2090-6846 2090-6854 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pulmonology |
| spelling | doaj-art-307bb7c3a18e4a3e998b2e882ab653632025-02-03T01:11:44ZengWileyCase Reports in Pulmonology2090-68462090-68542019-01-01201910.1155/2019/64583026458302A Case of Isolated Primary Pleural Neurofibroma in a 39-Year-Old WomanKritika Krishnamurthy0John Alexis1Pukhraz Basra2Ana Maria Medina3AM Rywlin Department of Pathology and Laboratory Medicine , Mount Sinai Medical Centre, Miami Beach, FL, USAAM Rywlin Department of Pathology and Laboratory Medicine , Mount Sinai Medical Centre, Miami Beach, FL, USAAM Rywlin Department of Pathology and Laboratory Medicine , Mount Sinai Medical Centre, Miami Beach, FL, USAAM Rywlin Department of Pathology and Laboratory Medicine , Mount Sinai Medical Centre, Miami Beach, FL, USAPrimary benign neurogenic neoplasms of the pleura are exceedingly rare. Neurofibromas rarely involve the pleura. A review of the literarture reveals only a single reported case of isolated pleural neurofibroma. Herein the authors describe another case of isolated primary pleural neurofibroma. A 39-year-old nonsmoker woman presented to the emergency room with complaints of progressively worsening chest pain of one month duration. A computed tomography of the chest revealed a crescent shaped, pleural based mass suspicious for a neurogenic tumor such as an intercostal schwannoma. A PET-CT skull base to midthigh failed to reveal any other masses or abnormalities. A surgical excision of the mass was performed due to the patient’s intractable pain. The resected specimen consisted of an ovoid fragment of soft tissue with pale yellow, smooth and glistening cut surface. Microscopic examination revealed the tumor to be composed of spindle cells with wavy nuclei arranged haphazardly in loose collagenous and pale myxoid stroma with rare interspersed mast cells. The spindle cells were diffusely positive for S100 protein and SOX-10, and focally positive for neurofilament. In the absence of any other masses in the patient and no pertinent history, a diagnosis of primary pleural neurofibroma was made. This case emphasizes the need to consider neurofibroma in any spindle cell neoplasm of the pleura irrespective of age or singularity.http://dx.doi.org/10.1155/2019/6458302 |
| spellingShingle | Kritika Krishnamurthy John Alexis Pukhraz Basra Ana Maria Medina A Case of Isolated Primary Pleural Neurofibroma in a 39-Year-Old Woman Case Reports in Pulmonology |
| title | A Case of Isolated Primary Pleural Neurofibroma in a 39-Year-Old Woman |
| title_full | A Case of Isolated Primary Pleural Neurofibroma in a 39-Year-Old Woman |
| title_fullStr | A Case of Isolated Primary Pleural Neurofibroma in a 39-Year-Old Woman |
| title_full_unstemmed | A Case of Isolated Primary Pleural Neurofibroma in a 39-Year-Old Woman |
| title_short | A Case of Isolated Primary Pleural Neurofibroma in a 39-Year-Old Woman |
| title_sort | case of isolated primary pleural neurofibroma in a 39 year old woman |
| url | http://dx.doi.org/10.1155/2019/6458302 |
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