Exploring imitation of within hand prehensile object manipulation using fMRI and graph theory analysis
Abstract This study aims to establish an imitation task of multi-finger haptics in the context of regular grasping and regrasping processes during activities of daily living. A video guided the 26 healthy, right-handed volunteers through the three phases of the task: (1) fixation of a hand holding a...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-86157-x |
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| author | Werner Krammer John H. Missimer Vanessa Vallesi Manuela Pastore-Wapp Georg Kägi Roland Wiest Bruno J. Weder |
| author_facet | Werner Krammer John H. Missimer Vanessa Vallesi Manuela Pastore-Wapp Georg Kägi Roland Wiest Bruno J. Weder |
| author_sort | Werner Krammer |
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| description | Abstract This study aims to establish an imitation task of multi-finger haptics in the context of regular grasping and regrasping processes during activities of daily living. A video guided the 26 healthy, right-handed volunteers through the three phases of the task: (1) fixation of a hand holding a cuboid, (2) observation of the sensori-motor manipulation, (3) imitation of that motor action. fMRI recorded the task; graph analysis of the acquisitions revealed the associated functional cerebral connectivity patterns. Inferred from four 60 ROI weighted graphs, the functional connectivities are consistent with a motor plan for observation and manipulation in the left hemisphere and with a network in the right hemisphere involving the inferior frontal gyrus, the site of intentional control of imitation. The networks exhibit (1) rich clubs which include sensori-motor hand, dorsal attention and cingulo-opercular communities for observation and motor execution in both hemispheres and (2) diversity clubs, significant only for manipulation and observation of the left hand, which include the dorsal visual association cortex, suggesting enhanced visual perception required for guiding the movement-limited left fingers. Short pathway analyses are consistent with these findings, confirming preferential involvement of ventral premotor cortices in the mirror network. |
| format | Article |
| id | doaj-art-3073177268f642b188c394259f391afa |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-3073177268f642b188c394259f391afa2025-02-02T12:21:37ZengNature PortfolioScientific Reports2045-23222025-01-0115111710.1038/s41598-025-86157-xExploring imitation of within hand prehensile object manipulation using fMRI and graph theory analysisWerner Krammer0John H. Missimer1Vanessa Vallesi2Manuela Pastore-Wapp3Georg Kägi4Roland Wiest5Bruno J. Weder6Support Centre for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of BernLaboratory of Biomolecular Research, Paul Scherrer InstituteSupport Centre for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of BernSupport Centre for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of BernDepartment of Neurology, Kantonsspital St. GallenSupport Centre for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of BernSupport Centre for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of BernAbstract This study aims to establish an imitation task of multi-finger haptics in the context of regular grasping and regrasping processes during activities of daily living. A video guided the 26 healthy, right-handed volunteers through the three phases of the task: (1) fixation of a hand holding a cuboid, (2) observation of the sensori-motor manipulation, (3) imitation of that motor action. fMRI recorded the task; graph analysis of the acquisitions revealed the associated functional cerebral connectivity patterns. Inferred from four 60 ROI weighted graphs, the functional connectivities are consistent with a motor plan for observation and manipulation in the left hemisphere and with a network in the right hemisphere involving the inferior frontal gyrus, the site of intentional control of imitation. The networks exhibit (1) rich clubs which include sensori-motor hand, dorsal attention and cingulo-opercular communities for observation and motor execution in both hemispheres and (2) diversity clubs, significant only for manipulation and observation of the left hand, which include the dorsal visual association cortex, suggesting enhanced visual perception required for guiding the movement-limited left fingers. Short pathway analyses are consistent with these findings, confirming preferential involvement of ventral premotor cortices in the mirror network.https://doi.org/10.1038/s41598-025-86157-xGraspingFinger gaitingAction imitationFunctional MRIGraph theoretical analysis |
| spellingShingle | Werner Krammer John H. Missimer Vanessa Vallesi Manuela Pastore-Wapp Georg Kägi Roland Wiest Bruno J. Weder Exploring imitation of within hand prehensile object manipulation using fMRI and graph theory analysis Scientific Reports Grasping Finger gaiting Action imitation Functional MRI Graph theoretical analysis |
| title | Exploring imitation of within hand prehensile object manipulation using fMRI and graph theory analysis |
| title_full | Exploring imitation of within hand prehensile object manipulation using fMRI and graph theory analysis |
| title_fullStr | Exploring imitation of within hand prehensile object manipulation using fMRI and graph theory analysis |
| title_full_unstemmed | Exploring imitation of within hand prehensile object manipulation using fMRI and graph theory analysis |
| title_short | Exploring imitation of within hand prehensile object manipulation using fMRI and graph theory analysis |
| title_sort | exploring imitation of within hand prehensile object manipulation using fmri and graph theory analysis |
| topic | Grasping Finger gaiting Action imitation Functional MRI Graph theoretical analysis |
| url | https://doi.org/10.1038/s41598-025-86157-x |
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