Role of arginase 1 from myeloid cells in th2-dominated lung inflammation.

Role of arginase 1 from myeloid cells in th2-dominated lung inflammation.

Th2-driven lung inflammation increases Arginase 1 (Arg1) expression in alternatively-activated macrophages (AAMs). AAMs modulate T cell and wound healing responses and Arg1 might contribute to asthma pathogenesis by inhibiting nitric oxide production, regulating fibrosis, modulating arginine metabol...

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Bibliographic Details
Main Authors: Luke Barron, Amber M Smith, Karim C El Kasmi, Joseph E Qualls, Xiaozhu Huang, Allen Cheever, Lee A Borthwick, Mark S Wilson, Peter J Murray, Thomas A Wynn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061961&type=printable
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