Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression
Background. Dengue virus (DENV) infection is the most common arboviral disease that affects tropical and subtropical regions. Based on the clinical hallmarks, the different severities of patients range from mild dengue fever (MDF) to severe dengue diseases (SDDs) and include dengue hemorrhagic fever...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/7652569 |
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| author | Josephine Diony Nanda Chiau-Jing Jung Rahmat Dani Satria Ming-Kai Jhan Ting-Jing Shen Po-Chun Tseng Yung-Ting Wang Tzong-Shiann Ho Chiou-Feng Lin |
| author_facet | Josephine Diony Nanda Chiau-Jing Jung Rahmat Dani Satria Ming-Kai Jhan Ting-Jing Shen Po-Chun Tseng Yung-Ting Wang Tzong-Shiann Ho Chiou-Feng Lin |
| author_sort | Josephine Diony Nanda |
| collection | DOAJ |
| description | Background. Dengue virus (DENV) infection is the most common arboviral disease that affects tropical and subtropical regions. Based on the clinical hallmarks, the different severities of patients range from mild dengue fever (MDF) to severe dengue diseases (SDDs) and include dengue hemorrhagic fever or dengue shock syndrome. These are commonly associated with cytokine release syndrome (CRS). The types and levels of cytokines/chemokines, which are suppressed or enhanced, are varied, indicating CRS’s pathogenic and host defensive effects. Principal Finding. In this study, we created an integrated and precise multiplex panel of cytokine/chemokine assays based on our literature analysis to monitor dengue CRS. A 24-plex panel of cytokines/chemokines was evaluated to measure the plasma levels of targeting factors in dengue patients with an MDF and SDD diagnosis without or with comorbidities. As identified in sixteen kinds of cytokines/chemokines, ten were significantly (P<0.05) (10/16) increased, one was significantly (P<0.01) (1/16) decreased, and five were potentially (5/16) altered in all dengue patients (n=30) in the acute phase of disease onset. Compared to MDF, the levels of IL-8 (CXCL-8) and IL-18 in SDD were markedly (P<0.05) increased, accompanied by positively increased IL-6 and TNF-α and decreased IFN-γ and RANTES. With comorbidities, SDD significantly (P<0.01) portrayed elevated IL-18 accompanied by increased IL-6 and decreased IFN-α2 and IL-12. In addition, decreased platelets were significantly (P<0.05) associated with increased IL-18. Significance. These results demonstrate an efficient panel of dengue cytokine/chemokine assays used to explore the possible level of CRS during the acute phase of disease onset; also, we are the first to report the increase of IL-18 in severe dengue with comorbidity compared to severe dengue without comorbidity and mild dengue. |
| format | Article |
| id | doaj-art-30614651fdba4b30bbea58052353cb3a |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-30614651fdba4b30bbea58052353cb3a2025-02-03T01:24:47ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/76525697652569Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease ProgressionJosephine Diony Nanda0Chiau-Jing Jung1Rahmat Dani Satria2Ming-Kai Jhan3Ting-Jing Shen4Po-Chun Tseng5Yung-Ting Wang6Tzong-Shiann Ho7Chiou-Feng Lin8International Ph.D. Program in Cell Therapy and Regenerative Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanDepartment of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanDepartment of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanDepartment of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanDepartment of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanDepartment of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanDepartment of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanDepartment of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, TaiwanInternational Ph.D. Program in Cell Therapy and Regenerative Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanBackground. Dengue virus (DENV) infection is the most common arboviral disease that affects tropical and subtropical regions. Based on the clinical hallmarks, the different severities of patients range from mild dengue fever (MDF) to severe dengue diseases (SDDs) and include dengue hemorrhagic fever or dengue shock syndrome. These are commonly associated with cytokine release syndrome (CRS). The types and levels of cytokines/chemokines, which are suppressed or enhanced, are varied, indicating CRS’s pathogenic and host defensive effects. Principal Finding. In this study, we created an integrated and precise multiplex panel of cytokine/chemokine assays based on our literature analysis to monitor dengue CRS. A 24-plex panel of cytokines/chemokines was evaluated to measure the plasma levels of targeting factors in dengue patients with an MDF and SDD diagnosis without or with comorbidities. As identified in sixteen kinds of cytokines/chemokines, ten were significantly (P<0.05) (10/16) increased, one was significantly (P<0.01) (1/16) decreased, and five were potentially (5/16) altered in all dengue patients (n=30) in the acute phase of disease onset. Compared to MDF, the levels of IL-8 (CXCL-8) and IL-18 in SDD were markedly (P<0.05) increased, accompanied by positively increased IL-6 and TNF-α and decreased IFN-γ and RANTES. With comorbidities, SDD significantly (P<0.01) portrayed elevated IL-18 accompanied by increased IL-6 and decreased IFN-α2 and IL-12. In addition, decreased platelets were significantly (P<0.05) associated with increased IL-18. Significance. These results demonstrate an efficient panel of dengue cytokine/chemokine assays used to explore the possible level of CRS during the acute phase of disease onset; also, we are the first to report the increase of IL-18 in severe dengue with comorbidity compared to severe dengue without comorbidity and mild dengue.http://dx.doi.org/10.1155/2021/7652569 |
| spellingShingle | Josephine Diony Nanda Chiau-Jing Jung Rahmat Dani Satria Ming-Kai Jhan Ting-Jing Shen Po-Chun Tseng Yung-Ting Wang Tzong-Shiann Ho Chiou-Feng Lin Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression Journal of Immunology Research |
| title | Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression |
| title_full | Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression |
| title_fullStr | Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression |
| title_full_unstemmed | Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression |
| title_short | Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression |
| title_sort | serum il 18 is a potential biomarker for predicting severe dengue disease progression |
| url | http://dx.doi.org/10.1155/2021/7652569 |
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