Novel yeast Pichia kudriavzevii alleviates aflatoxins induced toxicopathology in broiler chickens through immunomodulation and antioxidant enhancement
This study aimed to investigate the potential of Pichia kudriavzevii (PK), a newly discovered yeast strain, in alleviating the deleterious effects induced by aflatoxins on broilers. Eighty one-day-old broiler chicks were divided into four groups and subjected to various combinations of aflatoxin dos...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324017159 |
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| author | Ashiq Ali Aisha Khatoon Muhammad Kashif Saleemi Rao Zahid Abbas Bilal Murtaza Kaynaat Akbar Qaisar Tanveer Sami Ullah Khan Bahadur Hissah Abdulrahman Alodaini Mai Ahmad Alghamdi |
| author_facet | Ashiq Ali Aisha Khatoon Muhammad Kashif Saleemi Rao Zahid Abbas Bilal Murtaza Kaynaat Akbar Qaisar Tanveer Sami Ullah Khan Bahadur Hissah Abdulrahman Alodaini Mai Ahmad Alghamdi |
| author_sort | Ashiq Ali |
| collection | DOAJ |
| description | This study aimed to investigate the potential of Pichia kudriavzevii (PK), a newly discovered yeast strain, in alleviating the deleterious effects induced by aflatoxins on broilers. Eighty one-day-old broiler chicks were divided into four groups and subjected to various combinations of aflatoxin dosages at 300 μg/kg of feed alongside PK supplementation at 1 g/kg of feed. Assessment encompassed a comprehensive array of parameters including performance metrics, hepatic and renal biomarkers, interleukin concentrations, blood cell counts, hemoglobin concentration, packed cell volume, antibody response to sheep red blood cells, lymphoproliferative response to PHA-P, phagocytic response utilizing the carbon clearance assay system, as well as evaluation of oxidants and antioxidants. Additionally, gross and microscopic lesions on liver and kidney were examined. The study highlights Pichia kudriavzevii as a promising agent for mitigating aflatoxin-induced toxicity in broiler chicks by improving antioxidant and immunomodulatory status, normalizing biomarkers, and reversing pathological alterations through multifaceted protective mechanisms. |
| format | Article |
| id | doaj-art-30612f2d5b414318a5e4321acfc786cd |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-30612f2d5b414318a5e4321acfc786cd2025-01-23T05:25:56ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117639Novel yeast Pichia kudriavzevii alleviates aflatoxins induced toxicopathology in broiler chickens through immunomodulation and antioxidant enhancementAshiq Ali0Aisha Khatoon1Muhammad Kashif Saleemi2Rao Zahid Abbas3Bilal Murtaza4Kaynaat Akbar5Qaisar Tanveer6Sami Ullah Khan Bahadur7Hissah Abdulrahman Alodaini8Mai Ahmad Alghamdi9Department of Histology and Embryology, Shantou University Medical College, Shantou, China; Corresponding authors.Department of Pathology, University of Agriculture Faisalabad, Pakistan; Corresponding authors.Department of Pathology, University of Agriculture Faisalabad, PakistanDepartment of Parasitology, University of Agriculture Faisalabad, PakistanSchool of Bioengineering, Dalian University of Science and Technology, Dalian, ChinaDepartment of Zoology, University of Agriculture Faisalabad, PakistanThe Roslin Institute, The Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Edinburgh, UKCollege of Veterinary Medicine and Biomedical Sciences, Colorado state University, Fort Clins, USADepartment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaThis study aimed to investigate the potential of Pichia kudriavzevii (PK), a newly discovered yeast strain, in alleviating the deleterious effects induced by aflatoxins on broilers. Eighty one-day-old broiler chicks were divided into four groups and subjected to various combinations of aflatoxin dosages at 300 μg/kg of feed alongside PK supplementation at 1 g/kg of feed. Assessment encompassed a comprehensive array of parameters including performance metrics, hepatic and renal biomarkers, interleukin concentrations, blood cell counts, hemoglobin concentration, packed cell volume, antibody response to sheep red blood cells, lymphoproliferative response to PHA-P, phagocytic response utilizing the carbon clearance assay system, as well as evaluation of oxidants and antioxidants. Additionally, gross and microscopic lesions on liver and kidney were examined. The study highlights Pichia kudriavzevii as a promising agent for mitigating aflatoxin-induced toxicity in broiler chicks by improving antioxidant and immunomodulatory status, normalizing biomarkers, and reversing pathological alterations through multifaceted protective mechanisms.http://www.sciencedirect.com/science/article/pii/S0147651324017159Pichia kudriavzeviiAflatoxinsBroilersImmunomodulationAntioxidantHistopathology |
| spellingShingle | Ashiq Ali Aisha Khatoon Muhammad Kashif Saleemi Rao Zahid Abbas Bilal Murtaza Kaynaat Akbar Qaisar Tanveer Sami Ullah Khan Bahadur Hissah Abdulrahman Alodaini Mai Ahmad Alghamdi Novel yeast Pichia kudriavzevii alleviates aflatoxins induced toxicopathology in broiler chickens through immunomodulation and antioxidant enhancement Ecotoxicology and Environmental Safety Pichia kudriavzevii Aflatoxins Broilers Immunomodulation Antioxidant Histopathology |
| title | Novel yeast Pichia kudriavzevii alleviates aflatoxins induced toxicopathology in broiler chickens through immunomodulation and antioxidant enhancement |
| title_full | Novel yeast Pichia kudriavzevii alleviates aflatoxins induced toxicopathology in broiler chickens through immunomodulation and antioxidant enhancement |
| title_fullStr | Novel yeast Pichia kudriavzevii alleviates aflatoxins induced toxicopathology in broiler chickens through immunomodulation and antioxidant enhancement |
| title_full_unstemmed | Novel yeast Pichia kudriavzevii alleviates aflatoxins induced toxicopathology in broiler chickens through immunomodulation and antioxidant enhancement |
| title_short | Novel yeast Pichia kudriavzevii alleviates aflatoxins induced toxicopathology in broiler chickens through immunomodulation and antioxidant enhancement |
| title_sort | novel yeast pichia kudriavzevii alleviates aflatoxins induced toxicopathology in broiler chickens through immunomodulation and antioxidant enhancement |
| topic | Pichia kudriavzevii Aflatoxins Broilers Immunomodulation Antioxidant Histopathology |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324017159 |
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