Metalloproteinases (MMPs) in hypertensive disorders: role, function, pharmacology, and potential strategies to mitigate pathophysiological changes

Metalloproteinases (MMPs) in hypertensive disorders: role, function, pharmacology, and potential strategies to mitigate pathophysiological changes

Matrix metalloproteinases (MMPs) are a family of enzymes that play an important role in the pathophysiology of hypertensive disorders, particularly through their involvement in extracellular matrix (ECM) remodeling and vascular dysfunction. Their activity is closely linked to hypertension-mediated o...

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Bibliographic Details
Main Authors: Soroush Taherkhani, Mohammad Sheibani, Ali Mohammadkhanizadeh, Jitka A. I. Virag, Lisandra de Castro Braz, Yaser Azizi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
MMPs
ECM
hypertensive disorders
vascular remodeling
TIMPs
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1559288/full
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