Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease
Parkinson's disease (PD) is associated with various nonmotor symptoms including neuropsychiatric and cognitive dysfunction. We examined the relation between apathy, anxiety, side of onset of motor symptoms, and cognition in PD. We hypothesized that PD patients would show different neuropsychiat...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2012/793076 |
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| _version_ | 1832548108201885696 |
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| author | Yelena Bogdanova Alice Cronin-Golomb |
| author_facet | Yelena Bogdanova Alice Cronin-Golomb |
| author_sort | Yelena Bogdanova |
| collection | DOAJ |
| description | Parkinson's disease (PD) is associated with various nonmotor symptoms including neuropsychiatric and cognitive dysfunction. We examined the relation between apathy, anxiety, side of onset of motor symptoms, and cognition in PD. We hypothesized that PD patients would show different neuropsychiatric and neurocognitive profiles depending on the side of onset. 22 nondemented PD patients (11 right-side onset (RPD) with predominant left-hemisphere pathology, and 11 LPD) and 22 matched healthy controls (NC) were administered rating scales assessing apathy and anxiety, and a series of neuropsychological tests. PD patients showed a higher anxiety level than NC. There was a significant association between apathy, anxiety, and disease duration. In LPD, apathy but not anxiety was associated with performance on nonverbally mediated executive function and visuospatial measures, whereas, in RPD, anxiety but not apathy correlated with performance on verbally mediated tasks. Our findings demonstrated a differential association of apathy and anxiety to cognition in PD. |
| format | Article |
| id | doaj-art-305381dbf5e64671a10598ec645528c8 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-305381dbf5e64671a10598ec645528c82025-02-03T06:42:06ZengWileyParkinson's Disease2090-80832042-00802012-01-01201210.1155/2012/793076793076Neurocognitive Correlates of Apathy and Anxiety in Parkinson's DiseaseYelena Bogdanova0Alice Cronin-Golomb1Department of Psychology, Boston University, Boston, MA 02215, USADepartment of Psychology, Boston University, Boston, MA 02215, USAParkinson's disease (PD) is associated with various nonmotor symptoms including neuropsychiatric and cognitive dysfunction. We examined the relation between apathy, anxiety, side of onset of motor symptoms, and cognition in PD. We hypothesized that PD patients would show different neuropsychiatric and neurocognitive profiles depending on the side of onset. 22 nondemented PD patients (11 right-side onset (RPD) with predominant left-hemisphere pathology, and 11 LPD) and 22 matched healthy controls (NC) were administered rating scales assessing apathy and anxiety, and a series of neuropsychological tests. PD patients showed a higher anxiety level than NC. There was a significant association between apathy, anxiety, and disease duration. In LPD, apathy but not anxiety was associated with performance on nonverbally mediated executive function and visuospatial measures, whereas, in RPD, anxiety but not apathy correlated with performance on verbally mediated tasks. Our findings demonstrated a differential association of apathy and anxiety to cognition in PD.http://dx.doi.org/10.1155/2012/793076 |
| spellingShingle | Yelena Bogdanova Alice Cronin-Golomb Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease Parkinson's Disease |
| title | Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease |
| title_full | Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease |
| title_fullStr | Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease |
| title_full_unstemmed | Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease |
| title_short | Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease |
| title_sort | neurocognitive correlates of apathy and anxiety in parkinson s disease |
| url | http://dx.doi.org/10.1155/2012/793076 |
| work_keys_str_mv | AT yelenabogdanova neurocognitivecorrelatesofapathyandanxietyinparkinsonsdisease AT alicecroningolomb neurocognitivecorrelatesofapathyandanxietyinparkinsonsdisease |