Interleukin-10 in the Pathophysiology of Inflammatory Bowel Disease: Increased Serum Concentrations During the Recovery Phase
Using a specific enzyme-linked immunosorbent assay, IL-10 concentrations were measured in serum from 62 patients with ulcerative colitis (UC), 43 with Crohn's disease (CD), 25 with other colitides, and 44 normal control subjects. Serum IL-10 concentrations were increased in patients with active...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/26875 |
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| Summary: | Using a specific enzyme-linked immunosorbent assay, IL-10 concentrations were measured in serum from 62 patients with
ulcerative colitis (UC), 43 with Crohn's disease (CD), 25 with other colitides, and 44 normal
control subjects. Serum IL-10 concentrations were increased in patients with
active UC but not in those with active CD when compared with normal control subjects. A time course study
showed that in patients with UC and CD, serum concentrations of IL-6 and C-reactive protein
increased during the acute phase and returned to normal as patients go into remission. Notably,
serum IL-10 concentrations increased during the phase of disease resolution and declined
thereafter regardless of the treatment modality. Gel filtration analysis indicated that IL-10
circulated predominantly as a dimer. In conclusion, this study shows that serum IL-10 is
increased during disease recovery in patients with inflammatory bowel disease, and may be a
helpful marker in monitoring disease status. |
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| ISSN: | 0962-9351 1466-1861 |