Analgesic, Antioxidant, Anti-Inflammatory, and Wound-Treating Actions of Bitter Apricot Kernel Extract
Apricot (Prunus armeniaca L.) kernels have been widely employed in phytomedicine for treating different ailments. This study aims to unveil the phytochemical composition by HPLC-ESI-MS, in vitro antioxidant activity, and examine certain pharmacological effects of the hydro-ethanolic extract from bit...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Advances in Pharmacological and Pharmaceutical Sciences |
| Online Access: | http://dx.doi.org/10.1155/2024/5574259 |
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| author | Mohamed Amine El-Hajjaji Kawtar Fikri-Benbrahim Najoua Soulo Ghizlane Nouioura Hassan Laaroussi Pedro Ferreira-Santos Badiaa Lyoussi Zineb Benziane Ouaritini |
| author_facet | Mohamed Amine El-Hajjaji Kawtar Fikri-Benbrahim Najoua Soulo Ghizlane Nouioura Hassan Laaroussi Pedro Ferreira-Santos Badiaa Lyoussi Zineb Benziane Ouaritini |
| author_sort | Mohamed Amine El-Hajjaji |
| collection | DOAJ |
| description | Apricot (Prunus armeniaca L.) kernels have been widely employed in phytomedicine for treating different ailments. This study aims to unveil the phytochemical composition by HPLC-ESI-MS, in vitro antioxidant activity, and examine certain pharmacological effects of the hydro-ethanolic extract from bitter apricot kernels (BAK). Obtained results indicated that the BAK extract presents a content of 4.58 ± 0.15 mg GAE/g extract of TPA and 1.68 ± 0.09 mg QUE/g extract of TFA, respectively. HPLC-ESI-MS analysis discovered the presence of 17 phenolic compounds including phenolic acids and flavonoids like 3,4-dihydroxybenzoic acid, gallic acid, caffeic acid, (+)-catechin, epicatechin, and others, with associated antioxidant power. Regarding the studied potential pharmacological effects, notable analgesic activity at a dosage of 100 mg/kg BW was recorded with 63.46% protection. In the anti-inflammatory test, significant inhibition was observed after 6 hours of treatment (77.4%) compared to untreated animals. Moreover, the daily application of ointment formulated with 10% BAK extract resulted in a remarkable healing of wounds and burns in rats. These findings underscore the increasing evidence supporting the potential use of apricot kernel extracts in treating various diseases. |
| format | Article |
| id | doaj-art-304cfaa9af3a467097a0e5c10ec4349e |
| institution | Kabale University |
| issn | 2633-4690 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological and Pharmaceutical Sciences |
| spelling | doaj-art-304cfaa9af3a467097a0e5c10ec4349e2025-02-03T00:24:47ZengWileyAdvances in Pharmacological and Pharmaceutical Sciences2633-46902024-01-01202410.1155/2024/5574259Analgesic, Antioxidant, Anti-Inflammatory, and Wound-Treating Actions of Bitter Apricot Kernel ExtractMohamed Amine El-Hajjaji0Kawtar Fikri-Benbrahim1Najoua Soulo2Ghizlane Nouioura3Hassan Laaroussi4Pedro Ferreira-Santos5Badiaa Lyoussi6Zineb Benziane Ouaritini7Laboratory of Natural Substances, Pharmacology, Environment, ModelingLaboratory of Microbial Biotechnology and Bioactive Molecules, Sciences and Technologies FacultyLaboratory of Natural Substances, Pharmacology, Environment, ModelingLaboratory of Natural Substances, Pharmacology, Environment, ModelingLaboratory of Natural Substances, Pharmacology, Environment, ModelingDepartment of Chemical EngineeringLaboratory of Natural Substances, Pharmacology, Environment, ModelingLaboratory of Natural Substances, Pharmacology, Environment, ModelingApricot (Prunus armeniaca L.) kernels have been widely employed in phytomedicine for treating different ailments. This study aims to unveil the phytochemical composition by HPLC-ESI-MS, in vitro antioxidant activity, and examine certain pharmacological effects of the hydro-ethanolic extract from bitter apricot kernels (BAK). Obtained results indicated that the BAK extract presents a content of 4.58 ± 0.15 mg GAE/g extract of TPA and 1.68 ± 0.09 mg QUE/g extract of TFA, respectively. HPLC-ESI-MS analysis discovered the presence of 17 phenolic compounds including phenolic acids and flavonoids like 3,4-dihydroxybenzoic acid, gallic acid, caffeic acid, (+)-catechin, epicatechin, and others, with associated antioxidant power. Regarding the studied potential pharmacological effects, notable analgesic activity at a dosage of 100 mg/kg BW was recorded with 63.46% protection. In the anti-inflammatory test, significant inhibition was observed after 6 hours of treatment (77.4%) compared to untreated animals. Moreover, the daily application of ointment formulated with 10% BAK extract resulted in a remarkable healing of wounds and burns in rats. These findings underscore the increasing evidence supporting the potential use of apricot kernel extracts in treating various diseases.http://dx.doi.org/10.1155/2024/5574259 |
| spellingShingle | Mohamed Amine El-Hajjaji Kawtar Fikri-Benbrahim Najoua Soulo Ghizlane Nouioura Hassan Laaroussi Pedro Ferreira-Santos Badiaa Lyoussi Zineb Benziane Ouaritini Analgesic, Antioxidant, Anti-Inflammatory, and Wound-Treating Actions of Bitter Apricot Kernel Extract Advances in Pharmacological and Pharmaceutical Sciences |
| title | Analgesic, Antioxidant, Anti-Inflammatory, and Wound-Treating Actions of Bitter Apricot Kernel Extract |
| title_full | Analgesic, Antioxidant, Anti-Inflammatory, and Wound-Treating Actions of Bitter Apricot Kernel Extract |
| title_fullStr | Analgesic, Antioxidant, Anti-Inflammatory, and Wound-Treating Actions of Bitter Apricot Kernel Extract |
| title_full_unstemmed | Analgesic, Antioxidant, Anti-Inflammatory, and Wound-Treating Actions of Bitter Apricot Kernel Extract |
| title_short | Analgesic, Antioxidant, Anti-Inflammatory, and Wound-Treating Actions of Bitter Apricot Kernel Extract |
| title_sort | analgesic antioxidant anti inflammatory and wound treating actions of bitter apricot kernel extract |
| url | http://dx.doi.org/10.1155/2024/5574259 |
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