Risk factors and prediction model construction of urinary tract infection in elderly patients with diabetic nephropathy
[Objective] To analyze the risk factors of urinary tract infection in elderly patients with diabetic nephropathy, and to establish a predictive model. [Methods] From June 2018 to June 2023, a total of 240 elderly patients with type 2 diabetic nephropathy who visited General Hospital of Northern Thea...
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Editorial Office of International Journal of Geriatrics
2025-01-01
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| Series: | Guoji laonian yixue zazhi |
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| Online Access: | http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.01.011&lang=en |
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| _version_ | 1832592777186115584 |
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| author | Cong Feng Bo Yang Linlang Liang |
| author_facet | Cong Feng Bo Yang Linlang Liang |
| author_sort | Cong Feng |
| collection | DOAJ |
| description | [Objective] To analyze the risk factors of urinary tract infection in elderly patients with diabetic nephropathy, and to establish a predictive model. [Methods] From June 2018 to June 2023, a total of 240 elderly patients with type 2 diabetic nephropathy who visited General Hospital of Northern Theater Command of Chinese PLArmy Hospital were research object, of which 168 were included in disease group 1 and 72 were included in disease group 2.Disease group 1 included 52 cases of urinary tract infections (combined group) and 116 cases of non infection (non combined group); The disease group 2 included 26 cases of infection and 46 cases of non infection.Baseline and laboratory data were compared between disease group 1 and disease group 2, and between the combined group and non combined group; Multivariate logistic regression was applied to analyze the risk factors of urinary tract infections; The nomogram model was constructed based on the selected risk factors and validated, and consistency was checked by generating calibration curves. [Results] There was no significant difference in the data between disease group 1 and disease group 2 (P>0.05).The gender, course of disease, use of catheter, glycosylated hemoglobin (HbA1c), urinary albumin/creatinine ratio, estimated glomerular filtration rate(eGFR), and cystatin C(Cys-C) of the combined group and the non combined group in disease group 1 were statistically significant(P<0.05).Multivariate logistic regression analysis showed that female, urinary catheter, HbA1c>7.5%, high Cys-C and low eGFR were the risk factors of urinary tract infection in elderly patients with diabetes nephropathy (P<0.05).A nomogram was constructed from the results of multivariate logistic regression analysis.In the ROC curve for validating the nomogram model, the area under the curve was higher in disease group 1 and disease group 2 [0.915 (95%CI: 0.871~0.959) and 0.926 (95%CI: 0.865~0.986)] (P<0.05).The fitting test results showed that the application performance of the prediction model was good in the disease 1 group and the disease 2 group, and the difference between the prediction results and the actual results was not significant (P>0.05).Calibration curve showed that disease group 1 and disease group 2 were almost consistent with the ideal curve in this prediction model. [Conclusion] Female, urinary catheter, HbA1c>7.5%, high Cys-C and low eGFR are the risk factors of urinary tract infection in elderly patients with diabetic nephropathy.The prediction model has clinical advantages in accuracy and consistency. |
| format | Article |
| id | doaj-art-304a6c0a167e45628d26175225cec373 |
| institution | Kabale University |
| issn | 1674-7593 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Editorial Office of International Journal of Geriatrics |
| record_format | Article |
| series | Guoji laonian yixue zazhi |
| spelling | doaj-art-304a6c0a167e45628d26175225cec3732025-01-21T02:59:39ZzhoEditorial Office of International Journal of GeriatricsGuoji laonian yixue zazhi1674-75932025-01-01461525710.3969/j.issn.1674-7593.2025.01.011Risk factors and prediction model construction of urinary tract infection in elderly patients with diabetic nephropathyCong Feng0Bo Yang1Linlang Liang2Department of Endocrinology, General Hospital of Northern Theater Command of Chinese PLArmy Hospital, Shenyang 110016Department of Endocrinology, General Hospital of Northern Theater Command of Chinese PLArmy Hospital, Shenyang 110016Department of Endocrinology, General Hospital of Northern Theater Command of Chinese PLArmy Hospital, Shenyang 110016[Objective] To analyze the risk factors of urinary tract infection in elderly patients with diabetic nephropathy, and to establish a predictive model. [Methods] From June 2018 to June 2023, a total of 240 elderly patients with type 2 diabetic nephropathy who visited General Hospital of Northern Theater Command of Chinese PLArmy Hospital were research object, of which 168 were included in disease group 1 and 72 were included in disease group 2.Disease group 1 included 52 cases of urinary tract infections (combined group) and 116 cases of non infection (non combined group); The disease group 2 included 26 cases of infection and 46 cases of non infection.Baseline and laboratory data were compared between disease group 1 and disease group 2, and between the combined group and non combined group; Multivariate logistic regression was applied to analyze the risk factors of urinary tract infections; The nomogram model was constructed based on the selected risk factors and validated, and consistency was checked by generating calibration curves. [Results] There was no significant difference in the data between disease group 1 and disease group 2 (P>0.05).The gender, course of disease, use of catheter, glycosylated hemoglobin (HbA1c), urinary albumin/creatinine ratio, estimated glomerular filtration rate(eGFR), and cystatin C(Cys-C) of the combined group and the non combined group in disease group 1 were statistically significant(P<0.05).Multivariate logistic regression analysis showed that female, urinary catheter, HbA1c>7.5%, high Cys-C and low eGFR were the risk factors of urinary tract infection in elderly patients with diabetes nephropathy (P<0.05).A nomogram was constructed from the results of multivariate logistic regression analysis.In the ROC curve for validating the nomogram model, the area under the curve was higher in disease group 1 and disease group 2 [0.915 (95%CI: 0.871~0.959) and 0.926 (95%CI: 0.865~0.986)] (P<0.05).The fitting test results showed that the application performance of the prediction model was good in the disease 1 group and the disease 2 group, and the difference between the prediction results and the actual results was not significant (P>0.05).Calibration curve showed that disease group 1 and disease group 2 were almost consistent with the ideal curve in this prediction model. [Conclusion] Female, urinary catheter, HbA1c>7.5%, high Cys-C and low eGFR are the risk factors of urinary tract infection in elderly patients with diabetic nephropathy.The prediction model has clinical advantages in accuracy and consistency.http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.01.011&lang=endiabetic nephropathyurinary tract infectionrisk factorspredictionnomogram |
| spellingShingle | Cong Feng Bo Yang Linlang Liang Risk factors and prediction model construction of urinary tract infection in elderly patients with diabetic nephropathy Guoji laonian yixue zazhi diabetic nephropathy urinary tract infection risk factors prediction nomogram |
| title | Risk factors and prediction model construction of urinary tract infection in elderly patients with diabetic nephropathy |
| title_full | Risk factors and prediction model construction of urinary tract infection in elderly patients with diabetic nephropathy |
| title_fullStr | Risk factors and prediction model construction of urinary tract infection in elderly patients with diabetic nephropathy |
| title_full_unstemmed | Risk factors and prediction model construction of urinary tract infection in elderly patients with diabetic nephropathy |
| title_short | Risk factors and prediction model construction of urinary tract infection in elderly patients with diabetic nephropathy |
| title_sort | risk factors and prediction model construction of urinary tract infection in elderly patients with diabetic nephropathy |
| topic | diabetic nephropathy urinary tract infection risk factors prediction nomogram |
| url | http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.01.011&lang=en |
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