Engineering soft-hard tissue interfaces in dental and craniofacial system by spatially controlled bioactivities
The interface between soft and hard tissues is constituted by a gradient change of cell types and matrix compositions that are optimally designed for proper load transmission and injury protection. In the musculoskeletal system, the soft-hard tissue interfaces at tendon-bone, ligament-bone, and meni...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X2400522X |
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| author | Hun Jin Jeong Lan Anh P. Hoang Neeve Chen Elen Zhu Albert Wang Bozhi Chen Emma Y. Wang Christopher L. Ricupero Chang H. Lee |
| author_facet | Hun Jin Jeong Lan Anh P. Hoang Neeve Chen Elen Zhu Albert Wang Bozhi Chen Emma Y. Wang Christopher L. Ricupero Chang H. Lee |
| author_sort | Hun Jin Jeong |
| collection | DOAJ |
| description | The interface between soft and hard tissues is constituted by a gradient change of cell types and matrix compositions that are optimally designed for proper load transmission and injury protection. In the musculoskeletal system, the soft-hard tissue interfaces at tendon-bone, ligament-bone, and meniscus-bone have been extensively researched as regenerative targets. Similarly, extensive research efforts have been made to guide the regeneration of multi-tissue complexes in periodontium. However, the other soft-hard tissue interfaces in the dental and craniofacial system have been somewhat neglected. This review discusses the clinical significance of developing regenerative strategies for soft-hard tissue interfaces in the dental and craniofacial system. It also discusses the research progress in the field focused on bioengineering approaches using 3D scaffolds equipped with spatially controlled bioactivities. The remaining challenges, future perspectives, and considerations for the clinical translation of bioactive scaffolds are also discussed. |
| format | Article |
| id | doaj-art-301e741ccd2d47099fc6944ca2ca7044 |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-301e741ccd2d47099fc6944ca2ca70442025-01-26T05:04:25ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-03-0145246256Engineering soft-hard tissue interfaces in dental and craniofacial system by spatially controlled bioactivitiesHun Jin Jeong0Lan Anh P. Hoang1Neeve Chen2Elen Zhu3Albert Wang4Bozhi Chen5Emma Y. Wang6Christopher L. Ricupero7Chang H. Lee8College of Dental Medicine, Columbia University Irving Medical Center, 630 W. 168 St. – VC12-212, New York, NY, 10032, USACollege of Dental Medicine, Columbia University Irving Medical Center, 630 W. 168 St. – VC12-212, New York, NY, 10032, USACollege of Dental Medicine, Columbia University Irving Medical Center, 630 W. 168 St. – VC12-212, New York, NY, 10032, USACollege of Dental Medicine, Columbia University Irving Medical Center, 630 W. 168 St. – VC12-212, New York, NY, 10032, USACollege of Dental Medicine, Columbia University Irving Medical Center, 630 W. 168 St. – VC12-212, New York, NY, 10032, USACollege of Dental Medicine, Columbia University Irving Medical Center, 630 W. 168 St. – VC12-212, New York, NY, 10032, USACollege of Dental Medicine, Columbia University Irving Medical Center, 630 W. 168 St. – VC12-212, New York, NY, 10032, USACollege of Dental Medicine, Columbia University Irving Medical Center, 630 W. 168 St. – VC12-212, New York, NY, 10032, USACorresponding author. Regenerative Engineering Laboratory, Center for Dental and Craniofacial Research, College of Dental Medicine, Columbia University Medical Center, 630 W. 168 St. VC12-2, New York, NY, 10032, USA.; College of Dental Medicine, Columbia University Irving Medical Center, 630 W. 168 St. – VC12-212, New York, NY, 10032, USAThe interface between soft and hard tissues is constituted by a gradient change of cell types and matrix compositions that are optimally designed for proper load transmission and injury protection. In the musculoskeletal system, the soft-hard tissue interfaces at tendon-bone, ligament-bone, and meniscus-bone have been extensively researched as regenerative targets. Similarly, extensive research efforts have been made to guide the regeneration of multi-tissue complexes in periodontium. However, the other soft-hard tissue interfaces in the dental and craniofacial system have been somewhat neglected. This review discusses the clinical significance of developing regenerative strategies for soft-hard tissue interfaces in the dental and craniofacial system. It also discusses the research progress in the field focused on bioengineering approaches using 3D scaffolds equipped with spatially controlled bioactivities. The remaining challenges, future perspectives, and considerations for the clinical translation of bioactive scaffolds are also discussed.http://www.sciencedirect.com/science/article/pii/S2452199X2400522XMulti-tissue interfaceRegenerative engineeringBioactive scaffoldTissue engineeringTissue regenerationPeriodontium |
| spellingShingle | Hun Jin Jeong Lan Anh P. Hoang Neeve Chen Elen Zhu Albert Wang Bozhi Chen Emma Y. Wang Christopher L. Ricupero Chang H. Lee Engineering soft-hard tissue interfaces in dental and craniofacial system by spatially controlled bioactivities Bioactive Materials Multi-tissue interface Regenerative engineering Bioactive scaffold Tissue engineering Tissue regeneration Periodontium |
| title | Engineering soft-hard tissue interfaces in dental and craniofacial system by spatially controlled bioactivities |
| title_full | Engineering soft-hard tissue interfaces in dental and craniofacial system by spatially controlled bioactivities |
| title_fullStr | Engineering soft-hard tissue interfaces in dental and craniofacial system by spatially controlled bioactivities |
| title_full_unstemmed | Engineering soft-hard tissue interfaces in dental and craniofacial system by spatially controlled bioactivities |
| title_short | Engineering soft-hard tissue interfaces in dental and craniofacial system by spatially controlled bioactivities |
| title_sort | engineering soft hard tissue interfaces in dental and craniofacial system by spatially controlled bioactivities |
| topic | Multi-tissue interface Regenerative engineering Bioactive scaffold Tissue engineering Tissue regeneration Periodontium |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X2400522X |
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