Glucocorticoids and Preterm Hypoxic-Ischemic Brain Injury: The Good and the Bad
Fetuses at risk of premature delivery are now routinely exposed to maternal treatment with synthetic glucocorticoids. In randomized clinical trials, these substantially reduce acute neonatal systemic morbidity, and mortality, after premature birth and reduce intraventricular hemorrhage. However, the...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2012/751694 |
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| _version_ | 1832556944634675200 |
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| author | Laura Bennet Joanne O. Davidson Miriam Koome Alistair Jan Gunn |
| author_facet | Laura Bennet Joanne O. Davidson Miriam Koome Alistair Jan Gunn |
| author_sort | Laura Bennet |
| collection | DOAJ |
| description | Fetuses at risk of premature delivery are now routinely exposed to maternal treatment with synthetic glucocorticoids. In randomized clinical trials, these substantially reduce acute neonatal systemic morbidity, and mortality, after premature birth and reduce intraventricular hemorrhage. However, the overall neurodevelopmental impact is surprisingly unclear; worryingly, postnatal glucocorticoids are consistently associated with impaired brain development. We review the clinical and experimental evidence on how glucocorticoids may affect the developing brain and highlight the need for systematic research. |
| format | Article |
| id | doaj-art-300fd5c0f61a41b2a3d1c2dcbb86d07c |
| institution | Kabale University |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-300fd5c0f61a41b2a3d1c2dcbb86d07c2025-02-03T05:44:03ZengWileyJournal of Pregnancy2090-27272090-27352012-01-01201210.1155/2012/751694751694Glucocorticoids and Preterm Hypoxic-Ischemic Brain Injury: The Good and the BadLaura Bennet0Joanne O. Davidson1Miriam Koome2Alistair Jan Gunn3Fetal Physiology and Neuroscience Group, Department of Physiology, The University of Auckland, Auckland 1142, New ZealandFetal Physiology and Neuroscience Group, Department of Physiology, The University of Auckland, Auckland 1142, New ZealandFetal Physiology and Neuroscience Group, Department of Physiology, The University of Auckland, Auckland 1142, New ZealandFetal Physiology and Neuroscience Group, Department of Physiology, The University of Auckland, Auckland 1142, New ZealandFetuses at risk of premature delivery are now routinely exposed to maternal treatment with synthetic glucocorticoids. In randomized clinical trials, these substantially reduce acute neonatal systemic morbidity, and mortality, after premature birth and reduce intraventricular hemorrhage. However, the overall neurodevelopmental impact is surprisingly unclear; worryingly, postnatal glucocorticoids are consistently associated with impaired brain development. We review the clinical and experimental evidence on how glucocorticoids may affect the developing brain and highlight the need for systematic research.http://dx.doi.org/10.1155/2012/751694 |
| spellingShingle | Laura Bennet Joanne O. Davidson Miriam Koome Alistair Jan Gunn Glucocorticoids and Preterm Hypoxic-Ischemic Brain Injury: The Good and the Bad Journal of Pregnancy |
| title | Glucocorticoids and Preterm Hypoxic-Ischemic Brain Injury: The Good and the Bad |
| title_full | Glucocorticoids and Preterm Hypoxic-Ischemic Brain Injury: The Good and the Bad |
| title_fullStr | Glucocorticoids and Preterm Hypoxic-Ischemic Brain Injury: The Good and the Bad |
| title_full_unstemmed | Glucocorticoids and Preterm Hypoxic-Ischemic Brain Injury: The Good and the Bad |
| title_short | Glucocorticoids and Preterm Hypoxic-Ischemic Brain Injury: The Good and the Bad |
| title_sort | glucocorticoids and preterm hypoxic ischemic brain injury the good and the bad |
| url | http://dx.doi.org/10.1155/2012/751694 |
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