The neurotoxicity of iodoacetic acid, a byproduct of drinking water disinfection
IAA is a by-product of the water disinfection process and has been found to be neurotoxic. However, the role and mechanism of IAA neurotoxicity remain unclear. In this review, we comprehensively discuss the neurotoxic effects and mechanisms of IAA from the molecular level, cellular level and neurolo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Toxicology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/ftox.2025.1543374/full |
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| author | Xu Wang Xu Wang Xu Wang Chunshu Rong Ping Niu Wei Leng Gaihua Wang Ziqiao He Xin Qi Dexi Zhao Dexi Zhao Jinhua Li |
| author_facet | Xu Wang Xu Wang Xu Wang Chunshu Rong Ping Niu Wei Leng Gaihua Wang Ziqiao He Xin Qi Dexi Zhao Dexi Zhao Jinhua Li |
| author_sort | Xu Wang |
| collection | DOAJ |
| description | IAA is a by-product of the water disinfection process and has been found to be neurotoxic. However, the role and mechanism of IAA neurotoxicity remain unclear. In this review, we comprehensively discuss the neurotoxic effects and mechanisms of IAA from the molecular level, cellular level and neurological manifestations. At the molecular level, IAA causes neurotoxicity by reducing mitochondrial membrane potential, aggravating oxidative stress and DNA damage. At the cellular level, IAA causes neurotoxicity by inducing BBB disruption, neuroinflammation, and apoptosis. In neurological manifestations, IAA can lead to neurotransmitter disorders, neurodevelopment dysfunction, and even neurodegenerative diseases. Taken together, our review provides insights into the mechanisms of IAA neurotoxicity that will contribute to future studies of IAA neurotoxicity and its protective strategies. |
| format | Article |
| id | doaj-art-2ff8d937659a480380e02e76409b12fd |
| institution | Kabale University |
| issn | 2673-3080 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Toxicology |
| spelling | doaj-art-2ff8d937659a480380e02e76409b12fd2025-01-27T06:41:01ZengFrontiers Media S.A.Frontiers in Toxicology2673-30802025-01-01710.3389/ftox.2025.15433741543374The neurotoxicity of iodoacetic acid, a byproduct of drinking water disinfectionXu Wang0Xu Wang1Xu Wang2Chunshu Rong3Ping Niu4Wei Leng5Gaihua Wang6Ziqiao He7Xin Qi8Dexi Zhao9Dexi Zhao10Jinhua Li11Department of Encephalopathy, Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, ChinaSchool of Public Health, Jilin University, Changchun, Jilin, ChinaCollege of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, ChinaDepartment of Encephalopathy, Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, ChinaDepartment of Encephalopathy, Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, ChinaDepartment of Encephalopathy, Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, ChinaSchool of Public Health, Jilin University, Changchun, Jilin, ChinaSchool of Public Health, Jilin University, Changchun, Jilin, ChinaSchool of Public Health, Jilin University, Changchun, Jilin, ChinaDepartment of Encephalopathy, Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, ChinaCollege of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin, ChinaSchool of Public Health, Jilin University, Changchun, Jilin, ChinaIAA is a by-product of the water disinfection process and has been found to be neurotoxic. However, the role and mechanism of IAA neurotoxicity remain unclear. In this review, we comprehensively discuss the neurotoxic effects and mechanisms of IAA from the molecular level, cellular level and neurological manifestations. At the molecular level, IAA causes neurotoxicity by reducing mitochondrial membrane potential, aggravating oxidative stress and DNA damage. At the cellular level, IAA causes neurotoxicity by inducing BBB disruption, neuroinflammation, and apoptosis. In neurological manifestations, IAA can lead to neurotransmitter disorders, neurodevelopment dysfunction, and even neurodegenerative diseases. Taken together, our review provides insights into the mechanisms of IAA neurotoxicity that will contribute to future studies of IAA neurotoxicity and its protective strategies.https://www.frontiersin.org/articles/10.3389/ftox.2025.1543374/fullneurotoxicityneurodegenerationdisinfection byproductsiodoacetic acidneuroinflammation |
| spellingShingle | Xu Wang Xu Wang Xu Wang Chunshu Rong Ping Niu Wei Leng Gaihua Wang Ziqiao He Xin Qi Dexi Zhao Dexi Zhao Jinhua Li The neurotoxicity of iodoacetic acid, a byproduct of drinking water disinfection Frontiers in Toxicology neurotoxicity neurodegeneration disinfection byproducts iodoacetic acid neuroinflammation |
| title | The neurotoxicity of iodoacetic acid, a byproduct of drinking water disinfection |
| title_full | The neurotoxicity of iodoacetic acid, a byproduct of drinking water disinfection |
| title_fullStr | The neurotoxicity of iodoacetic acid, a byproduct of drinking water disinfection |
| title_full_unstemmed | The neurotoxicity of iodoacetic acid, a byproduct of drinking water disinfection |
| title_short | The neurotoxicity of iodoacetic acid, a byproduct of drinking water disinfection |
| title_sort | neurotoxicity of iodoacetic acid a byproduct of drinking water disinfection |
| topic | neurotoxicity neurodegeneration disinfection byproducts iodoacetic acid neuroinflammation |
| url | https://www.frontiersin.org/articles/10.3389/ftox.2025.1543374/full |
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