Drug Advances in NAFLD: Individual and Combination Treatment Strategies of Natural Products and Small-Synthetic-Molecule Drugs
Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease and is closely associated with metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome. However, effective treatment strategies for NAFLD are still lacking. In recent years,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/1/140 |
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| author | Xing Wan Jingyuan Ma He Bai Xuyang Hu Yanna Ma Mingjian Zhao Jifeng Liu Zhijun Duan |
| author_facet | Xing Wan Jingyuan Ma He Bai Xuyang Hu Yanna Ma Mingjian Zhao Jifeng Liu Zhijun Duan |
| author_sort | Xing Wan |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease and is closely associated with metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome. However, effective treatment strategies for NAFLD are still lacking. In recent years, progress has been made in understanding the pathogenesis of NAFLD, identifying multiple therapeutic targets and providing new directions for drug development. This review summarizes the recent advances in the treatment of NAFLD, focusing on the mechanisms of action of natural products, small-synthetic-molecule drugs, and combination therapy strategies. This review aims to provide new insights and strategies in treating NAFLD. |
| format | Article |
| id | doaj-art-2ff4909935914d6bb21d09c1aabc3658 |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-2ff4909935914d6bb21d09c1aabc36582025-01-24T13:25:20ZengMDPI AGBiomolecules2218-273X2025-01-0115114010.3390/biom15010140Drug Advances in NAFLD: Individual and Combination Treatment Strategies of Natural Products and Small-Synthetic-Molecule DrugsXing Wan0Jingyuan Ma1He Bai2Xuyang Hu3Yanna Ma4Mingjian Zhao5Jifeng Liu6Zhijun Duan7The First Affiliated Hospital of Dalian Medical University, Dalian 116012, ChinaThe First Clinical Medical College, Liaoning University of Traditional Chinese Medicine, Shenyang 110033, ChinaThe First Affiliated Hospital of Dalian Medical University, Dalian 116012, ChinaThe Second Clinical Medical College, Liaoning University of Traditional Chinese Medicine, Shenyang 110033, ChinaThe First Clinical Medical College, Liaoning University of Traditional Chinese Medicine, Shenyang 110033, ChinaThe First Affiliated Hospital of Dalian Medical University, Dalian 116012, ChinaThe First Affiliated Hospital of Dalian Medical University, Dalian 116012, ChinaThe First Affiliated Hospital of Dalian Medical University, Dalian 116012, ChinaNon-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease and is closely associated with metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome. However, effective treatment strategies for NAFLD are still lacking. In recent years, progress has been made in understanding the pathogenesis of NAFLD, identifying multiple therapeutic targets and providing new directions for drug development. This review summarizes the recent advances in the treatment of NAFLD, focusing on the mechanisms of action of natural products, small-synthetic-molecule drugs, and combination therapy strategies. This review aims to provide new insights and strategies in treating NAFLD.https://www.mdpi.com/2218-273X/15/1/140NAFLDnatural productssmall-synthetic-molecule drugs |
| spellingShingle | Xing Wan Jingyuan Ma He Bai Xuyang Hu Yanna Ma Mingjian Zhao Jifeng Liu Zhijun Duan Drug Advances in NAFLD: Individual and Combination Treatment Strategies of Natural Products and Small-Synthetic-Molecule Drugs Biomolecules NAFLD natural products small-synthetic-molecule drugs |
| title | Drug Advances in NAFLD: Individual and Combination Treatment Strategies of Natural Products and Small-Synthetic-Molecule Drugs |
| title_full | Drug Advances in NAFLD: Individual and Combination Treatment Strategies of Natural Products and Small-Synthetic-Molecule Drugs |
| title_fullStr | Drug Advances in NAFLD: Individual and Combination Treatment Strategies of Natural Products and Small-Synthetic-Molecule Drugs |
| title_full_unstemmed | Drug Advances in NAFLD: Individual and Combination Treatment Strategies of Natural Products and Small-Synthetic-Molecule Drugs |
| title_short | Drug Advances in NAFLD: Individual and Combination Treatment Strategies of Natural Products and Small-Synthetic-Molecule Drugs |
| title_sort | drug advances in nafld individual and combination treatment strategies of natural products and small synthetic molecule drugs |
| topic | NAFLD natural products small-synthetic-molecule drugs |
| url | https://www.mdpi.com/2218-273X/15/1/140 |
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