Right Ventricular Remodeling and Dysfunction in Obstructive Sleep Apnea: A Systematic Review of the Literature and Meta-Analysis
Background. Recent studies have reported that obstructive sleep apnea (OSA) patients present alterations in right ventricular (RV) structure and function. However, large randomized controlled trials evaluating the impact of OSA on the right ventricle are lacking. Methods. A comprehensive electronic...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2017/1587865 |
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| author | Abdirashit Maripov Argen Mamazhakypov Meerim Sartmyrzaeva Almaz Akunov Kubatbek Muratali uulu Melis Duishobaev Meerim Cholponbaeva Akylbek Sydykov Akpay Sarybaev |
| author_facet | Abdirashit Maripov Argen Mamazhakypov Meerim Sartmyrzaeva Almaz Akunov Kubatbek Muratali uulu Melis Duishobaev Meerim Cholponbaeva Akylbek Sydykov Akpay Sarybaev |
| author_sort | Abdirashit Maripov |
| collection | DOAJ |
| description | Background. Recent studies have reported that obstructive sleep apnea (OSA) patients present alterations in right ventricular (RV) structure and function. However, large randomized controlled trials evaluating the impact of OSA on the right ventricle are lacking. Methods. A comprehensive electronic database (PubMed, Web of Science, and Google Scholar) and reference search up to October 30, 2016, was performed. A systematic review and meta-analysis were performed to assess RV structure and function in OSA patients based on conventional echocardiography and tissue Doppler imaging. Results. Twenty-five studies with 1,503 OSA patients and 796 controls were included in this study. OSA patients exhibited an increase in RV internal diameter (weighted mean difference (WMD) (95% confidence intervals (CIs)) 2.49 (1.62 to 3.37); p=0.000) and RV wall thickness (WMD (95% CIs) 0.82 (0.51 to 1.13); p=0.000). Furthermore, OSA patients had a significantly elevated RV myocardial performance index (WMD (95% CI) 0.08 (0.06 to 0.10); p=0.000), decreased RV S’ (WMD (95% CI) −0.95 (−1.59 to −0.32); p=0.003), tricuspid annular plane systolic excursion (WMD (95% CI) −1.76 (−2.73 to −0.78); p=0.000), and RV fractional area change (WMD (95% CI) −3.16 (−5.60 to −0.73); p=0.011). Conclusion. OSA patients display RV dilatation, increased wall thickening, and altered RV function. |
| format | Article |
| id | doaj-art-2fe7ebb33c354ee0b44770dd74df9463 |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-2fe7ebb33c354ee0b44770dd74df94632025-02-03T01:26:51ZengWileyCanadian Respiratory Journal1198-22411916-72452017-01-01201710.1155/2017/15878651587865Right Ventricular Remodeling and Dysfunction in Obstructive Sleep Apnea: A Systematic Review of the Literature and Meta-AnalysisAbdirashit Maripov0Argen Mamazhakypov1Meerim Sartmyrzaeva2Almaz Akunov3Kubatbek Muratali uulu4Melis Duishobaev5Meerim Cholponbaeva6Akylbek Sydykov7Akpay Sarybaev8Department of Mountain and Sleep Medicine and Pulmonary Hypertension, National Center of Cardiology and Internal Medicine, Bishkek, KyrgyzstanDepartment of Mountain and Sleep Medicine and Pulmonary Hypertension, National Center of Cardiology and Internal Medicine, Bishkek, KyrgyzstanDepartment of Mountain and Sleep Medicine and Pulmonary Hypertension, National Center of Cardiology and Internal Medicine, Bishkek, KyrgyzstanDepartment of Mountain and Sleep Medicine and Pulmonary Hypertension, National Center of Cardiology and Internal Medicine, Bishkek, KyrgyzstanDepartment of Mountain and Sleep Medicine and Pulmonary Hypertension, National Center of Cardiology and Internal Medicine, Bishkek, KyrgyzstanDepartment of Mountain and Sleep Medicine and Pulmonary Hypertension, National Center of Cardiology and Internal Medicine, Bishkek, KyrgyzstanDepartment of Mountain and Sleep Medicine and Pulmonary Hypertension, National Center of Cardiology and Internal Medicine, Bishkek, KyrgyzstanDepartment of Mountain and Sleep Medicine and Pulmonary Hypertension, National Center of Cardiology and Internal Medicine, Bishkek, KyrgyzstanDepartment of Mountain and Sleep Medicine and Pulmonary Hypertension, National Center of Cardiology and Internal Medicine, Bishkek, KyrgyzstanBackground. Recent studies have reported that obstructive sleep apnea (OSA) patients present alterations in right ventricular (RV) structure and function. However, large randomized controlled trials evaluating the impact of OSA on the right ventricle are lacking. Methods. A comprehensive electronic database (PubMed, Web of Science, and Google Scholar) and reference search up to October 30, 2016, was performed. A systematic review and meta-analysis were performed to assess RV structure and function in OSA patients based on conventional echocardiography and tissue Doppler imaging. Results. Twenty-five studies with 1,503 OSA patients and 796 controls were included in this study. OSA patients exhibited an increase in RV internal diameter (weighted mean difference (WMD) (95% confidence intervals (CIs)) 2.49 (1.62 to 3.37); p=0.000) and RV wall thickness (WMD (95% CIs) 0.82 (0.51 to 1.13); p=0.000). Furthermore, OSA patients had a significantly elevated RV myocardial performance index (WMD (95% CI) 0.08 (0.06 to 0.10); p=0.000), decreased RV S’ (WMD (95% CI) −0.95 (−1.59 to −0.32); p=0.003), tricuspid annular plane systolic excursion (WMD (95% CI) −1.76 (−2.73 to −0.78); p=0.000), and RV fractional area change (WMD (95% CI) −3.16 (−5.60 to −0.73); p=0.011). Conclusion. OSA patients display RV dilatation, increased wall thickening, and altered RV function.http://dx.doi.org/10.1155/2017/1587865 |
| spellingShingle | Abdirashit Maripov Argen Mamazhakypov Meerim Sartmyrzaeva Almaz Akunov Kubatbek Muratali uulu Melis Duishobaev Meerim Cholponbaeva Akylbek Sydykov Akpay Sarybaev Right Ventricular Remodeling and Dysfunction in Obstructive Sleep Apnea: A Systematic Review of the Literature and Meta-Analysis Canadian Respiratory Journal |
| title | Right Ventricular Remodeling and Dysfunction in Obstructive Sleep Apnea: A Systematic Review of the Literature and Meta-Analysis |
| title_full | Right Ventricular Remodeling and Dysfunction in Obstructive Sleep Apnea: A Systematic Review of the Literature and Meta-Analysis |
| title_fullStr | Right Ventricular Remodeling and Dysfunction in Obstructive Sleep Apnea: A Systematic Review of the Literature and Meta-Analysis |
| title_full_unstemmed | Right Ventricular Remodeling and Dysfunction in Obstructive Sleep Apnea: A Systematic Review of the Literature and Meta-Analysis |
| title_short | Right Ventricular Remodeling and Dysfunction in Obstructive Sleep Apnea: A Systematic Review of the Literature and Meta-Analysis |
| title_sort | right ventricular remodeling and dysfunction in obstructive sleep apnea a systematic review of the literature and meta analysis |
| url | http://dx.doi.org/10.1155/2017/1587865 |
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