Colorectal Polyposis and Immune-Based Therapies
The progression from precancerous (adenomatous) colon polyps to malignant colorectal cancer involves the complex actions of various cytokines on T cell proliferation, cell-cell adhesion, apoptosis and host immunity. A broad spectrum of new treatments, including innovative molecular therapies such as...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2004-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2004/742713 |
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| _version_ | 1832553529755041792 |
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| author | Pearl Jacobson-Brown Manuela G Neuman |
| author_facet | Pearl Jacobson-Brown Manuela G Neuman |
| author_sort | Pearl Jacobson-Brown |
| collection | DOAJ |
| description | The progression from precancerous (adenomatous) colon polyps to malignant colorectal cancer involves the complex actions of various cytokines on T cell proliferation, cell-cell adhesion, apoptosis and host immunity. A broad spectrum of new treatments, including innovative molecular therapies such as gene therapy and treatment with cytokines, is under experimental and preclinical investigation. Nonsteroidal anti-inflammatory drugs and selective cyclooxygenase-2 inhibitors have traditionally been used as inflammation-reducing agents in cases of colon adenoma. Currently, adjuvant immunotherapies such as recombinant gene therapy and antibody-cytokine fusion proteins are assuming a more significant role in the management of colorectal neoplasia. Furthermore, advances in antitumour necrosis factor antibodies for the treatment of ulcerative colitis and Crohn's disease may have potential as chemoprotective agents for the treatment of colon polyposis. The present review aims to discuss the immunological mechanisms underlying colon tumour progression and the molecular and immune-based therapies that are leading to new methods of prognosis and treatment. |
| format | Article |
| id | doaj-art-2fe0b2b5b6624b37a284e56387714822 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-2fe0b2b5b6624b37a284e563877148222025-02-03T05:53:47ZengWileyCanadian Journal of Gastroenterology0835-79002004-01-0118423924910.1155/2004/742713Colorectal Polyposis and Immune-Based TherapiesPearl Jacobson-Brown0Manuela G Neuman1In Vitro Toxicology Laboratory, Kunin-Lunenfeld Applied Research Unit, Baycrest Centre for Geriatric Care, Toronto, CanadaIn Vitro Toxicology Laboratory, Kunin-Lunenfeld Applied Research Unit, Baycrest Centre for Geriatric Care, Toronto, CanadaThe progression from precancerous (adenomatous) colon polyps to malignant colorectal cancer involves the complex actions of various cytokines on T cell proliferation, cell-cell adhesion, apoptosis and host immunity. A broad spectrum of new treatments, including innovative molecular therapies such as gene therapy and treatment with cytokines, is under experimental and preclinical investigation. Nonsteroidal anti-inflammatory drugs and selective cyclooxygenase-2 inhibitors have traditionally been used as inflammation-reducing agents in cases of colon adenoma. Currently, adjuvant immunotherapies such as recombinant gene therapy and antibody-cytokine fusion proteins are assuming a more significant role in the management of colorectal neoplasia. Furthermore, advances in antitumour necrosis factor antibodies for the treatment of ulcerative colitis and Crohn's disease may have potential as chemoprotective agents for the treatment of colon polyposis. The present review aims to discuss the immunological mechanisms underlying colon tumour progression and the molecular and immune-based therapies that are leading to new methods of prognosis and treatment.http://dx.doi.org/10.1155/2004/742713 |
| spellingShingle | Pearl Jacobson-Brown Manuela G Neuman Colorectal Polyposis and Immune-Based Therapies Canadian Journal of Gastroenterology |
| title | Colorectal Polyposis and Immune-Based Therapies |
| title_full | Colorectal Polyposis and Immune-Based Therapies |
| title_fullStr | Colorectal Polyposis and Immune-Based Therapies |
| title_full_unstemmed | Colorectal Polyposis and Immune-Based Therapies |
| title_short | Colorectal Polyposis and Immune-Based Therapies |
| title_sort | colorectal polyposis and immune based therapies |
| url | http://dx.doi.org/10.1155/2004/742713 |
| work_keys_str_mv | AT pearljacobsonbrown colorectalpolyposisandimmunebasedtherapies AT manuelagneuman colorectalpolyposisandimmunebasedtherapies |