Structural basis of FpGalNase and its combination with FpGalNAcDeAc for efficient A-to-O blood group conversion

Structural basis of FpGalNase and its combination with FpGalNAcDeAc for efficient A-to-O blood group conversion

Abstract Transfusion safety and blood typing continue to present significant challenges in clinical practice, including risks of incorrect blood transfusions and blood shortages. One promising solution is the enzymatic conversion of all red blood cell (RBC) types into universal O-type RBCs. However,...

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Bibliographic Details
Main Authors: Meiling Zhou, Kaishan Luo, Chao Su, Yan Sun, Zuyan Huang, Shuo Ma, Xun Gao, Jiwei Wang, Chen Zhang, Pengcheng Han, Guoqiu Wu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Experimental Hematology & Oncology
Subjects:
Blood transfusion
FpGalNAcDeAc
FpGalNase
Galactosaminidase
N-acetylgalactosamine deacetylase
cryo-EM structure
Online Access:https://doi.org/10.1186/s40164-025-00599-7
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