TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin
Polymorphisms have been identified in the Xq28 locus as risk loci for rheumatoid arthritis (RA). Here, we investigated the association between three polymorphisms in the Xq28 region containing TMEM187 and IRAK1 (rs13397, rs1059703, and rs1059702) in two unstudied populations: Tunisian and French. Th...
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| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/4915950 |
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| author | Olfa Khalifa Nathalie Balandraud Nathalie Lambert Isabelle Auger Jean Roudier Audrey Sénéchal David Geneviève Christophe Picard Gérard Lefranc Isabelle Touitou Bakridine M’Madi Mrenda Cécilia Benedito Etienne Pardoux Anne-Laure Gagez Yves-Marie Pers Christian Jorgensen Touhami Mahjoub Florence Apparailly |
| author_facet | Olfa Khalifa Nathalie Balandraud Nathalie Lambert Isabelle Auger Jean Roudier Audrey Sénéchal David Geneviève Christophe Picard Gérard Lefranc Isabelle Touitou Bakridine M’Madi Mrenda Cécilia Benedito Etienne Pardoux Anne-Laure Gagez Yves-Marie Pers Christian Jorgensen Touhami Mahjoub Florence Apparailly |
| author_sort | Olfa Khalifa |
| collection | DOAJ |
| description | Polymorphisms have been identified in the Xq28 locus as risk loci for rheumatoid arthritis (RA). Here, we investigated the association between three polymorphisms in the Xq28 region containing TMEM187 and IRAK1 (rs13397, rs1059703, and rs1059702) in two unstudied populations: Tunisian and French. The rs13397 G and rs1059703 T major alleles were significantly increased in RA patients (n=408) compared with age-matched controls (n=471) in both Tunisian and French women. These results were confirmed by a meta-analysis replication study including two independent Greek and Korean cohorts. The rs1059702 C major allele was significantly associated with RA, only with French women. In the French population, the GTC haplotype displayed a protective effect against RA, while the ATC, GCC, and GTT haplotypes conferred significant risk for RA. No association for these haplotypes was found in the Tunisian population. Our results replicated for the first time the association of the three Xq28 polymorphisms with RA risk in Tunisian and French populations and suggested that RA susceptibility is associated with TMEM187-IRAK1 polymorphisms in women. Our data further support the involvement of X chromosome in RA susceptibility and evidence ethnicities differences that might be explained by differences in the frequencies of SE HLA-DRB1 alleles between both populations. |
| format | Article |
| id | doaj-art-2fd7c867d9ba4c1dbc4efbaff8e6066f |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-2fd7c867d9ba4c1dbc4efbaff8e6066f2025-02-03T01:02:15ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/49159504915950TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic OriginOlfa Khalifa0Nathalie Balandraud1Nathalie Lambert2Isabelle Auger3Jean Roudier4Audrey Sénéchal5David Geneviève6Christophe Picard7Gérard Lefranc8Isabelle Touitou9Bakridine M’Madi Mrenda10Cécilia Benedito11Etienne Pardoux12Anne-Laure Gagez13Yves-Marie Pers14Christian Jorgensen15Touhami Mahjoub16Florence Apparailly17Inserm, U 1183, Institute for Regenerative Medicine and Biotherapies, CHU Saint Eloi, 80 Avenue Augustin Fliche, 34295 Montpellier Cedex 5, FranceInserm UMRs 1097, Aix-Marseille University, Marseille, FranceInserm UMRs 1097, Aix-Marseille University, Marseille, FranceInserm UMRs 1097, Aix-Marseille University, Marseille, FranceInserm UMRs 1097, Aix-Marseille University, Marseille, FranceInserm, U1051, University Hospital Saint Eloi, Institute for Neurosciences of Montpellier, Montpellier, FranceInserm, U 1183, Institute for Regenerative Medicine and Biotherapies, CHU Saint Eloi, 80 Avenue Augustin Fliche, 34295 Montpellier Cedex 5, FranceAix-Marseille University, CNRS, EFS, ADES UMR 7268, 13916 Marseille, FranceUniversity of Montpellier, Boulevard Henri IV, 34090 Montpellier, FranceInserm, U 1183, Institute for Regenerative Medicine and Biotherapies, CHU Saint Eloi, 80 Avenue Augustin Fliche, 34295 Montpellier Cedex 5, FranceAix-Marseille University, CNRS, Centrale Marseille, I2M, UMR 7373, 13453 Marseille, FranceAix-Marseille University, CNRS, Centrale Marseille, I2M, UMR 7373, 13453 Marseille, FranceAix-Marseille University, CNRS, Centrale Marseille, I2M, UMR 7373, 13453 Marseille, FranceCNRS UMR 5235, Université de Montpellier, Montpellier, FranceInserm, U 1183, Institute for Regenerative Medicine and Biotherapies, CHU Saint Eloi, 80 Avenue Augustin Fliche, 34295 Montpellier Cedex 5, FranceInserm, U 1183, Institute for Regenerative Medicine and Biotherapies, CHU Saint Eloi, 80 Avenue Augustin Fliche, 34295 Montpellier Cedex 5, FranceLaboratory of Human Genome and Multifactorial Diseases, Faculty of Pharmacy, University of Monastir, Monastir, TunisiaInserm, U 1183, Institute for Regenerative Medicine and Biotherapies, CHU Saint Eloi, 80 Avenue Augustin Fliche, 34295 Montpellier Cedex 5, FrancePolymorphisms have been identified in the Xq28 locus as risk loci for rheumatoid arthritis (RA). Here, we investigated the association between three polymorphisms in the Xq28 region containing TMEM187 and IRAK1 (rs13397, rs1059703, and rs1059702) in two unstudied populations: Tunisian and French. The rs13397 G and rs1059703 T major alleles were significantly increased in RA patients (n=408) compared with age-matched controls (n=471) in both Tunisian and French women. These results were confirmed by a meta-analysis replication study including two independent Greek and Korean cohorts. The rs1059702 C major allele was significantly associated with RA, only with French women. In the French population, the GTC haplotype displayed a protective effect against RA, while the ATC, GCC, and GTT haplotypes conferred significant risk for RA. No association for these haplotypes was found in the Tunisian population. Our results replicated for the first time the association of the three Xq28 polymorphisms with RA risk in Tunisian and French populations and suggested that RA susceptibility is associated with TMEM187-IRAK1 polymorphisms in women. Our data further support the involvement of X chromosome in RA susceptibility and evidence ethnicities differences that might be explained by differences in the frequencies of SE HLA-DRB1 alleles between both populations.http://dx.doi.org/10.1155/2017/4915950 |
| spellingShingle | Olfa Khalifa Nathalie Balandraud Nathalie Lambert Isabelle Auger Jean Roudier Audrey Sénéchal David Geneviève Christophe Picard Gérard Lefranc Isabelle Touitou Bakridine M’Madi Mrenda Cécilia Benedito Etienne Pardoux Anne-Laure Gagez Yves-Marie Pers Christian Jorgensen Touhami Mahjoub Florence Apparailly TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin Journal of Immunology Research |
| title | TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin |
| title_full | TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin |
| title_fullStr | TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin |
| title_full_unstemmed | TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin |
| title_short | TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin |
| title_sort | tmem187 irak1 polymorphisms associated with rheumatoid arthritis susceptibility in tunisian and french female populations influence of geographic origin |
| url | http://dx.doi.org/10.1155/2017/4915950 |
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