Efficacy of Transcutaneous Electrical Acupoint Stimulation on Modulating Upper Extremity Sympathetic Skin Response in Alleviating Cancer Survivors With Chemotherapy-Induced Peripheral Neuropathy: A Propensity Score-Matched Cohort Study
Yongming Xu,1,* Junzhen Wu,1,* Qingqing Jiang,2 Yingying Lv,1 Jin Zhou,1 Zhiyu Wang,3 Hui Zhao,3 Dongping Du1 1Department of Pain Management Center, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China;...
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Dove Medical Press
2025-01-01
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| Series: | Journal of Pain Research |
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| author | Xu Y Wu J Jiang Q Lv Y Zhou J Wang Z Zhao H Du D |
| author_facet | Xu Y Wu J Jiang Q Lv Y Zhou J Wang Z Zhao H Du D |
| author_sort | Xu Y |
| collection | DOAJ |
| description | Yongming Xu,1,* Junzhen Wu,1,* Qingqing Jiang,2 Yingying Lv,1 Jin Zhou,1 Zhiyu Wang,3 Hui Zhao,3 Dongping Du1 1Department of Pain Management Center, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Neurology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 3Department of Internal Oncology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dongping Du, Department of Pain Management Center, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China, Tel +86-21-24058896, Email dudp@sjtu.edu.cn Hui Zhao, Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai, 200233, People’s Republic of China, Tel +86-21-24058328, Fax +86-21-240598328, Email zhao-hui@sjtu.edu.cnObjective: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of chemotherapy and it is currently intractable We compared the efficacy of transcutaneous electrical acupoint stimulation (TEAS) against non-TEAS groups and investigated the variables that predict effective relief of upper extremity pain in cancer survivors with CIPN.Methods: We retrospectively collected data of cancer survivors who developed CIPN between May 2017 to March 2022. All eligible CIPN patients were divided into TEAS group (received TEAS) and non-TEAS group (did not receive TEAS) in our department. A 1:1 ratio propensity score matching (PSM) was used to balance the baseline features. The change of numerical rating scale (NRS), Short-Form McGill Pain Questionnaire-2 (SF-MPQ-2), and sympathetic skin response (SSR) parameters are all assessed after treatment. The procedure was considered a clinically effective relief if the patients’ NRS scores were reduced by 50% or more, and overall patients with effective relief were all counted after treatment. Furthermore, a multivariable logistic regression model was utilized to evaluate the predictors of effective relief following CIPN treatment.Results: : A total of 102 cancer survivors with CIPN were analyzed after PSM (51 in each group). The change of NRS, SF-MPQ-2, SSR latency and SSR amplitude in TEAS group were significantly higher than those in non-TEAS group at 3 weeks after therapy (all P< 0.01). In addition, the effective relief rate was significantly higher in TEAS group than in non-TEAS group (P=0.026). Multivariate logistic regression on the total study cohort showed that TEAS group (OR 2.783, P = 0.025) and the baseline SSR amplitude of the upper extremity < 1265 μV (OR 12.191, P = 0.000) were independent predictive factors for the clinical efficacy.Conclusions: : TEAS significantly decreased the severity of CIPN. TEAS group and baseline SSR amplitude of the upper extremity < 1265 μV were the independent predictive factors for the clinical efficacy after treatment.Keywords: transcutaneous electrical acupoint stimulation, chemotherapy-induced peripheral neuropathy, sympathetic skin response, cancer survivors, neuropathic pain |
| format | Article |
| id | doaj-art-2fd57597abbf43ae91af2e15dbf87b04 |
| institution | Kabale University |
| issn | 1178-7090 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Pain Research |
| spelling | doaj-art-2fd57597abbf43ae91af2e15dbf87b042025-01-21T16:58:06ZengDove Medical PressJournal of Pain Research1178-70902025-01-01Volume 1829330399420Efficacy of Transcutaneous Electrical Acupoint Stimulation on Modulating Upper Extremity Sympathetic Skin Response in Alleviating Cancer Survivors With Chemotherapy-Induced Peripheral Neuropathy: A Propensity Score-Matched Cohort StudyXu YWu JJiang QLv YZhou JWang ZZhao HDu DYongming Xu,1,* Junzhen Wu,1,* Qingqing Jiang,2 Yingying Lv,1 Jin Zhou,1 Zhiyu Wang,3 Hui Zhao,3 Dongping Du1 1Department of Pain Management Center, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Neurology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 3Department of Internal Oncology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dongping Du, Department of Pain Management Center, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China, Tel +86-21-24058896, Email dudp@sjtu.edu.cn Hui Zhao, Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai, 200233, People’s Republic of China, Tel +86-21-24058328, Fax +86-21-240598328, Email zhao-hui@sjtu.edu.cnObjective: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of chemotherapy and it is currently intractable We compared the efficacy of transcutaneous electrical acupoint stimulation (TEAS) against non-TEAS groups and investigated the variables that predict effective relief of upper extremity pain in cancer survivors with CIPN.Methods: We retrospectively collected data of cancer survivors who developed CIPN between May 2017 to March 2022. All eligible CIPN patients were divided into TEAS group (received TEAS) and non-TEAS group (did not receive TEAS) in our department. A 1:1 ratio propensity score matching (PSM) was used to balance the baseline features. The change of numerical rating scale (NRS), Short-Form McGill Pain Questionnaire-2 (SF-MPQ-2), and sympathetic skin response (SSR) parameters are all assessed after treatment. The procedure was considered a clinically effective relief if the patients’ NRS scores were reduced by 50% or more, and overall patients with effective relief were all counted after treatment. Furthermore, a multivariable logistic regression model was utilized to evaluate the predictors of effective relief following CIPN treatment.Results: : A total of 102 cancer survivors with CIPN were analyzed after PSM (51 in each group). The change of NRS, SF-MPQ-2, SSR latency and SSR amplitude in TEAS group were significantly higher than those in non-TEAS group at 3 weeks after therapy (all P< 0.01). In addition, the effective relief rate was significantly higher in TEAS group than in non-TEAS group (P=0.026). Multivariate logistic regression on the total study cohort showed that TEAS group (OR 2.783, P = 0.025) and the baseline SSR amplitude of the upper extremity < 1265 μV (OR 12.191, P = 0.000) were independent predictive factors for the clinical efficacy.Conclusions: : TEAS significantly decreased the severity of CIPN. TEAS group and baseline SSR amplitude of the upper extremity < 1265 μV were the independent predictive factors for the clinical efficacy after treatment.Keywords: transcutaneous electrical acupoint stimulation, chemotherapy-induced peripheral neuropathy, sympathetic skin response, cancer survivors, neuropathic painhttps://www.dovepress.com/efficacy-of-transcutaneous-electrical-acupoint-stimulation-on-modulati-peer-reviewed-fulltext-article-JPRtranscutaneous electrical acupoint stimulationchemotherapy-induced peripheral neuropathysympathetic skin responsecancer survivors； neuropathic pain |
| spellingShingle | Xu Y Wu J Jiang Q Lv Y Zhou J Wang Z Zhao H Du D Efficacy of Transcutaneous Electrical Acupoint Stimulation on Modulating Upper Extremity Sympathetic Skin Response in Alleviating Cancer Survivors With Chemotherapy-Induced Peripheral Neuropathy: A Propensity Score-Matched Cohort Study Journal of Pain Research transcutaneous electrical acupoint stimulation chemotherapy-induced peripheral neuropathy sympathetic skin response cancer survivors； neuropathic pain |
| title | Efficacy of Transcutaneous Electrical Acupoint Stimulation on Modulating Upper Extremity Sympathetic Skin Response in Alleviating Cancer Survivors With Chemotherapy-Induced Peripheral Neuropathy: A Propensity Score-Matched Cohort Study |
| title_full | Efficacy of Transcutaneous Electrical Acupoint Stimulation on Modulating Upper Extremity Sympathetic Skin Response in Alleviating Cancer Survivors With Chemotherapy-Induced Peripheral Neuropathy: A Propensity Score-Matched Cohort Study |
| title_fullStr | Efficacy of Transcutaneous Electrical Acupoint Stimulation on Modulating Upper Extremity Sympathetic Skin Response in Alleviating Cancer Survivors With Chemotherapy-Induced Peripheral Neuropathy: A Propensity Score-Matched Cohort Study |
| title_full_unstemmed | Efficacy of Transcutaneous Electrical Acupoint Stimulation on Modulating Upper Extremity Sympathetic Skin Response in Alleviating Cancer Survivors With Chemotherapy-Induced Peripheral Neuropathy: A Propensity Score-Matched Cohort Study |
| title_short | Efficacy of Transcutaneous Electrical Acupoint Stimulation on Modulating Upper Extremity Sympathetic Skin Response in Alleviating Cancer Survivors With Chemotherapy-Induced Peripheral Neuropathy: A Propensity Score-Matched Cohort Study |
| title_sort | efficacy of transcutaneous electrical acupoint stimulation on modulating upper extremity sympathetic skin response in alleviating cancer survivors with chemotherapy induced peripheral neuropathy a propensity score matched cohort study |
| topic | transcutaneous electrical acupoint stimulation chemotherapy-induced peripheral neuropathy sympathetic skin response cancer survivors； neuropathic pain |
| url | https://www.dovepress.com/efficacy-of-transcutaneous-electrical-acupoint-stimulation-on-modulati-peer-reviewed-fulltext-article-JPR |
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