Copious Podocyturia without Proteinuria and with Normal Renal Function in a Young Adult with Fabry Disease
The time for starting a patient with Fabry disease on enzyme replacement therapy is still a matter of debate, particularly when no overt classical clinical signs or symptoms are present. With respect to Fabry nephropathy, a dual problem coexists: the reluctance of many nephrologists to start enzyme...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2015/257628 |
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| author | H. Trimarchi R. Canzonieri A. Muryan A. Schiel A. Araoz M. Forrester A. Karl F. Lombi J. Andrews V. Pomeranz T. Rengel E. Zotta |
| author_facet | H. Trimarchi R. Canzonieri A. Muryan A. Schiel A. Araoz M. Forrester A. Karl F. Lombi J. Andrews V. Pomeranz T. Rengel E. Zotta |
| author_sort | H. Trimarchi |
| collection | DOAJ |
| description | The time for starting a patient with Fabry disease on enzyme replacement therapy is still a matter of debate, particularly when no overt classical clinical signs or symptoms are present. With respect to Fabry nephropathy, a dual problem coexists: the reluctance of many nephrologists to start enzyme replacement infusion until signs of renal disease appear as the appearance of proteinuria or an elevation in serum creatinine and the lack of validated biomarkers of early renal damage. In this regard, proteinuria is nowadays considered as an early and appropriate marker of kidney disease and of cardiovascular morbidity and mortality. However, in this report we demonstrate that podocyturia antedates the classical appearance of proteinuria and could be considered as an even earlier biomarker of kidney damage. Podocyturia may be a novel indication for the initiation of therapy in Fabry disease. |
| format | Article |
| id | doaj-art-2fd56fb2c57d45fb9e2915b50165a521 |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-2fd56fb2c57d45fb9e2915b50165a5212025-02-03T01:24:13ZengWileyCase Reports in Nephrology2090-66412090-665X2015-01-01201510.1155/2015/257628257628Copious Podocyturia without Proteinuria and with Normal Renal Function in a Young Adult with Fabry DiseaseH. Trimarchi0R. Canzonieri1A. Muryan2A. Schiel3A. Araoz4M. Forrester5A. Karl6F. Lombi7J. Andrews8V. Pomeranz9T. Rengel10E. Zotta11Nephrology Service, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, ArgentinaLaboratory Services, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, ArgentinaLaboratory Services, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, ArgentinaLaboratory Services, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, ArgentinaIFIBIO Houssay, UBA CONICET, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1425 Buenos Aires, ArgentinaNephrology Service, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, ArgentinaNephrology Service, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, ArgentinaNephrology Service, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, ArgentinaNephrology Service, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, ArgentinaNephrology Service, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, ArgentinaNephrology Service, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, ArgentinaIFIBIO Houssay, UBA CONICET, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1425 Buenos Aires, ArgentinaThe time for starting a patient with Fabry disease on enzyme replacement therapy is still a matter of debate, particularly when no overt classical clinical signs or symptoms are present. With respect to Fabry nephropathy, a dual problem coexists: the reluctance of many nephrologists to start enzyme replacement infusion until signs of renal disease appear as the appearance of proteinuria or an elevation in serum creatinine and the lack of validated biomarkers of early renal damage. In this regard, proteinuria is nowadays considered as an early and appropriate marker of kidney disease and of cardiovascular morbidity and mortality. However, in this report we demonstrate that podocyturia antedates the classical appearance of proteinuria and could be considered as an even earlier biomarker of kidney damage. Podocyturia may be a novel indication for the initiation of therapy in Fabry disease.http://dx.doi.org/10.1155/2015/257628 |
| spellingShingle | H. Trimarchi R. Canzonieri A. Muryan A. Schiel A. Araoz M. Forrester A. Karl F. Lombi J. Andrews V. Pomeranz T. Rengel E. Zotta Copious Podocyturia without Proteinuria and with Normal Renal Function in a Young Adult with Fabry Disease Case Reports in Nephrology |
| title | Copious Podocyturia without Proteinuria and with Normal Renal Function in a Young Adult with Fabry Disease |
| title_full | Copious Podocyturia without Proteinuria and with Normal Renal Function in a Young Adult with Fabry Disease |
| title_fullStr | Copious Podocyturia without Proteinuria and with Normal Renal Function in a Young Adult with Fabry Disease |
| title_full_unstemmed | Copious Podocyturia without Proteinuria and with Normal Renal Function in a Young Adult with Fabry Disease |
| title_short | Copious Podocyturia without Proteinuria and with Normal Renal Function in a Young Adult with Fabry Disease |
| title_sort | copious podocyturia without proteinuria and with normal renal function in a young adult with fabry disease |
| url | http://dx.doi.org/10.1155/2015/257628 |
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