Insertion/deletion polymorphism of the human leukocyte antigen G gene in pregnant women with threatened abortion
Introduction: The polymorphism of the human leukocyte antigen G gene is investigated in different complications related to pregnancy; however, it must be verified if there is an association between this genetic polymorphism and the threat of abortion. Objective: To establish the genetic association...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universidad de Ciencias Médicas de La Habana
2024-07-01
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| Series: | Revista Habanera de Ciencias Médicas |
| Subjects: | |
| Online Access: | https://revhabanera.sld.cu/index.php/rhab/article/view/5586 |
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| Summary: | Introduction: The polymorphism of the human leukocyte antigen G gene is investigated in different complications related to pregnancy; however, it must be verified if there is an association between this genetic polymorphism and the threat of abortion.
Objective: To establish the genetic association between the 14 base pair insertion/deletion polymorphism in exon 8 of the three non-translatable prime region of the human leukocyte antigen G gene with susceptibility to the threat of abortion in pregnant women from Camagüey.
Material and Methods: A case-control study was carried out, involving 22 pregnant women with threatened abortion and 65 pregnant women (control group). For the study, human deoxyribonucleic acid was obtained from peripheral blood, the polymerase chain reaction was used for the molecular typing of the genotypes and alleles that were identified by agarose gel electrophoresis.
Results: The most frequent genotype in the group of pregnant women with threatened abortion was insertion/deletion, while in the control group the deletion/deletion genotype predominated.
Conclusions: The insertion/deletion polymorphism of 14 base pairs in exon 8 of the 3’ non-translatable region of the human leukocyte antigen G gene represents a risk factor for the appearance of threatened abortion in pregnant women from Camagüey, while the expression of the deletion/deletion genotype represents a protective factor against this health condition. |
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| ISSN: | 1729-519X |