Lower Serum Level of Anti-tetanus Toxin Antibodies in Patients with Type 2 Diabetes Mellitus
Aim: to evaluate the serum levels of anti-tetanus toxin antibodies (anti-TTA) in patients with type 2 diabetes mellitus (DM) and in a control group. Methods: totally, 100 patients with type 2 DM and 100 age-and sex-matched healthy individuals were enrolled to study. The presence of type 2 DM confir...
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| Format: | Article |
| Language: | English |
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Interna Publishing
2016-05-01
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| Series: | Acta Medica Indonesiana |
| Online Access: | http://actamedindones.org/index.php/ijim/article/view/63 |
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| author | M. Nemati M. Zarrin S.A. Mir-Abdollahi M.T. Rezayati V. Mirzaee A. Bagheri M. Ebrahimi A. Jafarzadeh |
| author_facet | M. Nemati M. Zarrin S.A. Mir-Abdollahi M.T. Rezayati V. Mirzaee A. Bagheri M. Ebrahimi A. Jafarzadeh |
| author_sort | M. Nemati |
| collection | DOAJ |
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Aim: to evaluate the serum levels of anti-tetanus toxin antibodies (anti-TTA) in patients with type 2 diabetes mellitus (DM) and in a control group. Methods: totally, 100 patients with type 2 DM and 100 age-and sex-matched healthy individuals were enrolled to study. The presence of type 2 DM confirmed according to the clinical and para-clinical criteria such as fasting plasma glucose above 126 mg/dl. A peripheral blood sample was collected from all subjects. The serum samples of participants tested for the levels of anti-TTA by ELISA method. The serum antitoxin concentration ≥0.1 IU/mL was considered as a protective level of antibody. Results: the seroprotective rate in healthy group was significantly higher than diabetic group (99% vs. 92%; p<0.02). The mean titer of anti-TTA in healthy group (5.32±0.26 IU/ml) was also significantly higher than diabetic patients (3.46±0.26 IU/ml; p<0.001). In diabetic men the mean titer of anti-TTA was significantly higher in comparison to diabetic women (3.94±0.34 IU/ml vs 2.59±0.36 IU/ml; p<0.01). In diabetic patients the seroprotective rate and the mean titer of anti-TTA in subjects with age >40 years was also lower in comparison to those with age <40 years (89.23% vs 97.14%; p<0.15 and 4.57±0.38 IU/ml vs 2.86±0.32 IU/ml; P<0.002, respectively). The mean titer of anti-TTA was significantly higher in patients with diabetes duration <5 years in comparison to patients with disease duration >5 years (3.91±0.35 IU/ml vs 2.85±0.38 IU/ml; p<0.04). Conclusion: these results showed lower levels of anti-TTA in patients with type 2 DM, in diabetic women, in patients aged >40 years and in diabetic patients with disease duration >5 years .
Key words: immunity, tetanus, antibody, type 2 diabetes.
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| format | Article |
| id | doaj-art-2fc3517bc7bd4e2a8e6776eda5c513f4 |
| institution | DOAJ |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2016-05-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj-art-2fc3517bc7bd4e2a8e6776eda5c513f42025-08-20T02:57:46ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322016-05-01461Lower Serum Level of Anti-tetanus Toxin Antibodies in Patients with Type 2 Diabetes MellitusM. Nemati0M. Zarrin1S.A. Mir-Abdollahi2M.T. Rezayati3V. Mirzaee4A. Bagheri5M. Ebrahimi6A. Jafarzadeh7Department of Microbiology and Immunology, Medical School, Kerman University of Medical Sciences, Kerman, Iran.Department of Microbiology and Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, IranDepartment of Microbiology and Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, IranDepartment of Microbiology and Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, IranDepartment of Internal Medicine, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, IranDepartment of Microbiology and Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, IranPharmacology School, Shiraz University of Medical Sciences, Shiraz, IranMolecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Aim: to evaluate the serum levels of anti-tetanus toxin antibodies (anti-TTA) in patients with type 2 diabetes mellitus (DM) and in a control group. Methods: totally, 100 patients with type 2 DM and 100 age-and sex-matched healthy individuals were enrolled to study. The presence of type 2 DM confirmed according to the clinical and para-clinical criteria such as fasting plasma glucose above 126 mg/dl. A peripheral blood sample was collected from all subjects. The serum samples of participants tested for the levels of anti-TTA by ELISA method. The serum antitoxin concentration ≥0.1 IU/mL was considered as a protective level of antibody. Results: the seroprotective rate in healthy group was significantly higher than diabetic group (99% vs. 92%; p<0.02). The mean titer of anti-TTA in healthy group (5.32±0.26 IU/ml) was also significantly higher than diabetic patients (3.46±0.26 IU/ml; p<0.001). In diabetic men the mean titer of anti-TTA was significantly higher in comparison to diabetic women (3.94±0.34 IU/ml vs 2.59±0.36 IU/ml; p<0.01). In diabetic patients the seroprotective rate and the mean titer of anti-TTA in subjects with age >40 years was also lower in comparison to those with age <40 years (89.23% vs 97.14%; p<0.15 and 4.57±0.38 IU/ml vs 2.86±0.32 IU/ml; P<0.002, respectively). The mean titer of anti-TTA was significantly higher in patients with diabetes duration <5 years in comparison to patients with disease duration >5 years (3.91±0.35 IU/ml vs 2.85±0.38 IU/ml; p<0.04). Conclusion: these results showed lower levels of anti-TTA in patients with type 2 DM, in diabetic women, in patients aged >40 years and in diabetic patients with disease duration >5 years . Key words: immunity, tetanus, antibody, type 2 diabetes. http://actamedindones.org/index.php/ijim/article/view/63 |
| spellingShingle | M. Nemati M. Zarrin S.A. Mir-Abdollahi M.T. Rezayati V. Mirzaee A. Bagheri M. Ebrahimi A. Jafarzadeh Lower Serum Level of Anti-tetanus Toxin Antibodies in Patients with Type 2 Diabetes Mellitus Acta Medica Indonesiana |
| title | Lower Serum Level of Anti-tetanus Toxin Antibodies in Patients with Type 2 Diabetes Mellitus |
| title_full | Lower Serum Level of Anti-tetanus Toxin Antibodies in Patients with Type 2 Diabetes Mellitus |
| title_fullStr | Lower Serum Level of Anti-tetanus Toxin Antibodies in Patients with Type 2 Diabetes Mellitus |
| title_full_unstemmed | Lower Serum Level of Anti-tetanus Toxin Antibodies in Patients with Type 2 Diabetes Mellitus |
| title_short | Lower Serum Level of Anti-tetanus Toxin Antibodies in Patients with Type 2 Diabetes Mellitus |
| title_sort | lower serum level of anti tetanus toxin antibodies in patients with type 2 diabetes mellitus |
| url | http://actamedindones.org/index.php/ijim/article/view/63 |
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