Green jackfruit flour ameliorates MASH and development of HCC via the AMPK and MAPK signaling pathways in experimental model systems

Green jackfruit flour ameliorates MASH and development of HCC via the AMPK and MAPK signaling pathways in experimental model systems

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is a serious public health concern. Given the paucity of approved therapeutic strategies for this lifestyle disorder, dietary interventions may prove effective. We evaluated the mechanisms of how green jackfruit flour (JF) ame...

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Main Authors: Diwakar Suresh, Bharathwaaj Gunaseelan, Akshatha N. Srinivas, Amith Bharadwaj, James Joseph, Megha, Thomas Varughese, Suchitha Satish, Deepak Suvarna, Prasanna K. Santhekadur, Saravana Babu Chidambaram, Ajay Duseja, Divya P. Kumar
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
NAFLD
NASH
MASLD
Liver injury
Inflammation
Metabolic syndrome
Online Access:https://doi.org/10.1038/s41598-025-96944-1
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