Effect of Vitamin D Supplementation on the Treatment of Pulmonary Tuberculosis Patients in Different Polymorphisms of the Vitamin D Receptor
Background: Vitamin D leads to the activation of macrophages and limitation of intracellular growth of Mycobacterium tuberculosis. Vitamin D receptor (VDR) gene polymorphisms can facilitate the development of tuberculosis (TB). Therefore, the present study aimed to investigate the effect of vitamin...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-10-01
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| Series: | Advanced Biomedical Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/abr.abr_76_24 |
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| Summary: | Background:
Vitamin D leads to the activation of macrophages and limitation of intracellular growth of Mycobacterium tuberculosis. Vitamin D receptor (VDR) gene polymorphisms can facilitate the development of tuberculosis (TB). Therefore, the present study aimed to investigate the effect of vitamin D supplementation on response to treatment in patients with pulmonary TB for different VDR polymorphisms.
Materials and Methods:
This semiexperimental study was carried out over a 2-year period on 73 patients (37 females; 36 males) who suffered from pulmonary TB. Vitamin D supplement at a daily dose of 800 IU was administered to the patients for 8 weeks. The serum levels of vitamin D were measured by electrochemiluminescence immunoassay. The polymerase chain reaction with a sequence-specific primers technique was used to determine the polymorphisms FOK1, Bsm 1, Apa 1, and Taq1 of VDR gene.
Results:
The mean serum levels of vitamin D increased significantly after the intervention (44.88 ng/ml vs 27.70 ng/ml, P < 0.001). Those with FF genotype of Fok1 polymorphism had a higher chance of a positive response to treatment compared to the other genotypes (P = 0.044, 95% CI). Bsm1, Apa1, and Taq1 polymorphisms increased the treatment response, which was not statistically significant.
Conclusion:
The results of this study showed that individuals harboring FF genotype of Fok1 polymorphism had a higher chance of a positive response to treatment with vitamin D compared with other genotypes. Therefore, vitamin D supplement can be an appropriate treatment considering the genetic characteristics of TB patients. |
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| ISSN: | 2277-9175 |