Examining changes in serum levels of Irisin and Brain-Derived Neurotrophic Factor in inactive middle-aged men in two phases of training and detraining
Introduction: Resistance training increases irisin and brain-derived neurotrophic factor secretion, impacting myogenic regulatory factors and muscle function, but maintaining these adaptations remains a challenging challenge. Accordingly, the present study was designed to investigate changes in ser...
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Ilam University of Medical Sciences
2025-07-01
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| Series: | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām |
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| Online Access: | http://sjimu.medilam.ac.ir/article-1-8430-en.pdf |
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| author | Rezvan Afahar Masoud Rahmati Rahim Mirnasuri |
| author_facet | Rezvan Afahar Masoud Rahmati Rahim Mirnasuri |
| author_sort | Rezvan Afahar |
| collection | DOAJ |
| description | Introduction: Resistance training increases irisin and brain-derived neurotrophic factor secretion, impacting myogenic regulatory factors and muscle function, but maintaining these adaptations remains a challenging challenge. Accordingly, the present study was designed to investigate changes in serum irisin and brain-derived neurotrophic factor levels in inactive middle-aged men during two phases of training and detraining.
Materials & Methods: This quasi-experimental study was conducted on middle-aged men with an average age of 39.87±6.05 years. The exercise protocol was performed 3 times a week for 12 weeks, and then 24 weeks of detraining were performed. Irisin and brain-derived neurotrophic factor were measured on 3 occasions before the start of training, at 12 and 36 weeks. Repeated measures ANOVA and independent t-tests were used in SPSS V.27 with significance set at p≤0.05.
Results: Serum levels of Irisin, brain-derived neurotrophic factor, and muscle strength increased significantly after 12 weeks in the training group compared to the control group (p=0.001). However, 24 weeks of detraining led to a significant decrease in irisin and muscle strength to baseline levels, and no difference was observed between the training and control groups (p=0.001). While despite the significant decrease of brain-derived neurotrophic factor in the training group following detraining (p=0.001), the level of brain-derived neurotrophic factor in the training group remained higher than the control group (p=0.052), and a significant difference between the training group and control was observed (p=0.001).
Conclusion: Resistance training can improve muscle strength and increase irisin and brain-derived neurotrophic factor secretion in middle-aged people. |
| format | Article |
| id | doaj-art-2fbe4f556a2644458a285b0a272d731a |
| institution | Kabale University |
| issn | 1563-4728 2588-3135 |
| language | fas |
| publishDate | 2025-07-01 |
| publisher | Ilam University of Medical Sciences |
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| series | Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām |
| spelling | doaj-art-2fbe4f556a2644458a285b0a272d731a2025-08-25T07:35:14ZfasIlam University of Medical SciencesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām1563-47282588-31352025-07-013331426Examining changes in serum levels of Irisin and Brain-Derived Neurotrophic Factor in inactive middle-aged men in two phases of training and detrainingRezvan Afahar0Masoud Rahmati1Rahim Mirnasuri2 Dept of Physical Education and Sports Sciences, Faculty of Literature and Humanities, Lorestan University, Khorramabad, Iran Dept of Physical Education and Sports Sciences, Faculty of Literature and Humanities, Lorestan University, Khorramabad, Iran Dept of Physical Education and Sports Sciences, Faculty of Literature and Humanities, Lorestan University, Khorramabad, Iran Introduction: Resistance training increases irisin and brain-derived neurotrophic factor secretion, impacting myogenic regulatory factors and muscle function, but maintaining these adaptations remains a challenging challenge. Accordingly, the present study was designed to investigate changes in serum irisin and brain-derived neurotrophic factor levels in inactive middle-aged men during two phases of training and detraining. Materials & Methods: This quasi-experimental study was conducted on middle-aged men with an average age of 39.87±6.05 years. The exercise protocol was performed 3 times a week for 12 weeks, and then 24 weeks of detraining were performed. Irisin and brain-derived neurotrophic factor were measured on 3 occasions before the start of training, at 12 and 36 weeks. Repeated measures ANOVA and independent t-tests were used in SPSS V.27 with significance set at p≤0.05. Results: Serum levels of Irisin, brain-derived neurotrophic factor, and muscle strength increased significantly after 12 weeks in the training group compared to the control group (p=0.001). However, 24 weeks of detraining led to a significant decrease in irisin and muscle strength to baseline levels, and no difference was observed between the training and control groups (p=0.001). While despite the significant decrease of brain-derived neurotrophic factor in the training group following detraining (p=0.001), the level of brain-derived neurotrophic factor in the training group remained higher than the control group (p=0.052), and a significant difference between the training group and control was observed (p=0.001). Conclusion: Resistance training can improve muscle strength and increase irisin and brain-derived neurotrophic factor secretion in middle-aged people.http://sjimu.medilam.ac.ir/article-1-8430-en.pdfdetrainingirisinbrain-derived neurotrophic factorresistance training |
| spellingShingle | Rezvan Afahar Masoud Rahmati Rahim Mirnasuri Examining changes in serum levels of Irisin and Brain-Derived Neurotrophic Factor in inactive middle-aged men in two phases of training and detraining Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām detraining irisin brain-derived neurotrophic factor resistance training |
| title | Examining changes in serum levels of Irisin and Brain-Derived Neurotrophic Factor in inactive middle-aged men in two phases of training and detraining |
| title_full | Examining changes in serum levels of Irisin and Brain-Derived Neurotrophic Factor in inactive middle-aged men in two phases of training and detraining |
| title_fullStr | Examining changes in serum levels of Irisin and Brain-Derived Neurotrophic Factor in inactive middle-aged men in two phases of training and detraining |
| title_full_unstemmed | Examining changes in serum levels of Irisin and Brain-Derived Neurotrophic Factor in inactive middle-aged men in two phases of training and detraining |
| title_short | Examining changes in serum levels of Irisin and Brain-Derived Neurotrophic Factor in inactive middle-aged men in two phases of training and detraining |
| title_sort | examining changes in serum levels of irisin and brain derived neurotrophic factor in inactive middle aged men in two phases of training and detraining |
| topic | detraining irisin brain-derived neurotrophic factor resistance training |
| url | http://sjimu.medilam.ac.ir/article-1-8430-en.pdf |
| work_keys_str_mv | AT rezvanafahar examiningchangesinserumlevelsofirisinandbrainderivedneurotrophicfactorininactivemiddleagedmenintwophasesoftraininganddetraining AT masoudrahmati examiningchangesinserumlevelsofirisinandbrainderivedneurotrophicfactorininactivemiddleagedmenintwophasesoftraininganddetraining AT rahimmirnasuri examiningchangesinserumlevelsofirisinandbrainderivedneurotrophicfactorininactivemiddleagedmenintwophasesoftraininganddetraining |